Channel:  The Howard Hughes Medical Institute (HHMI)

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De novo design of phosphotyrosine peptide binders
Bauer, M. S., Zhang, J. Z., Wu, K., Lee, G. R., Coventry, B., Silvestri, I. M., Klupt, K. A., Shi, J., Brent, R. I., Li, X., Moller, C., Roullier, N., Vafeados, D. K., Kalvet, I., Skotheim, R. K., Zhu, S., Motmaen, A., Herrmann, L. C., Sturmfels, P., Tischer, D., Altae-Tran, H., Juergens, D., Krishna, R., Ahern, W., Yim, J., Bera, A. K., Kang, A., Joyce, E., Lu, A., Stewart, L., DiMaio, F., Mudumbi, K. C., Baker, D.
10.1101/2025.09.29.678898 — Posted: 2026-01-28
A molecularly defined basalo-prefrontal-thalamic circuit regulates sensory and affective dimensions of pain in male mice
Xie, G., Liu, Y., Qi, X., Bhattacherjee, A., Zhang, C., Zhang, Y.
10.1101/2025.08.22.671771 — Posted: 2026-01-28
Live dynamics of induced cell-cell fusion between mitotic and interphasic cells
Afonso, O., Feliciano, D., Lippincott-Schwartz, J.
10.64898/2026.01.27.700572 — Posted: 2026-01-27
Single-molecule dissection of CFTR folding defects and pharmacological rescue
Kim, S. A., Levring, J., Chen, J., Yoon, T.-Y.
10.64898/2026.01.26.701897 — Posted: 2026-01-27
T cell engagers control solid tumors through clonal replacement and IL2-driven effector differentiation of CD8 T-cells
Obenaus, M., Poupault, C. L., McGinnis, C. S., Prange, C., Jiang, H., Su, L. L., Chen, X., Miao, Z., Muldoon, J. J., Yao, W., Waghray, D., Sun, Q., Eyquem, J., Hernandez-Lopez, R. A., Satpathy, A. T., Sage, J., Garcia, K. C.
10.64898/2025.12.04.692214 — Posted: 2026-01-27
The spliceosome assembles on excised linear introns to protect them from degradation
Li, G. W., Wilkinson, M. E., Bartel, D. P.
10.64898/2026.01.21.700889 — Posted: 2026-01-27
Evolutionary innovation through fusion of sequences from across the tree of life
Kapoor, R., Schwager, E. E., Phuangphong, S., Rivard, E. L., Kuyyamudi, C., Ghosh, S., Ronai, I., Extavour, C. G.
10.1101/2025.08.30.672725 — Posted: 2026-01-27
Activating Ras-MAPK pathway variants drive hippocampal clonal competition in human epilepsy
Khoshkhoo, S., Bae, M., Wang, Y., Tillett, A., Ramirez, R. B., Finander, B., Egan, E. D., Marx, L., Patel, D., Zhou, Z., Chahine, Y., Chhouk, B., Zoullas, S. M., Lai, A., Coras, R., Bielle, F., Navarro, V., Mathon, B., Valiante, T. A., Chameh, H. M., Gao, A., Krings, T., Gooley, S., Hildebrand, M. S., Bulluss, K., Clark, J., Morokoff, A. P., King, J. A., Todaro, M., Kwan, P., O'Brien, T. J., Berkovic, S. F., Scheffer, I. E., Perucca, P., Lapinskas, E., Rolston, J. D., Cosgrove, G. R., Sarkis, R. A., D'Gama, A. M., Alexadrescu, S., Yang, E., Poduri, A., Richardson, R. M., Erson-Omay, E. Z., DeL
10.64898/2026.01.26.701822 — Posted: 2026-01-27
Defective splicing of Y-chromosome-linked gigantic genes contributes to hybrid male sterility in Drosophila
Fontan, A., Lannes, R., Fingerhut, J., Flynn, J., Yamashita, Y. M.
10.1101/2025.05.22.655455 — Posted: 2026-01-26
Comparative Proteomic Profiling of Receptor Kinase Signaling Reveals Key Trafficking Components Enforcing Plant Stomatal Development
Bai, P., Vu, M. H., Komatsu, C., Papoulas, O., Ebine, K., Nozawa, A., Sawasaki, T., Ueda, T., Marcotte, E. M., Torii, K. U.
10.1101/2025.07.20.665823 — Posted: 2026-01-26

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