Channel:  The Howard Hughes Medical Institute (HHMI)

2,398 Articles

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Nucleotide context models outperform protein language models for predicting antibody affinity maturation
Johnson, M. M., Sung, K., Haddox, H. K., Vora, A. A., Araki, T., Victora, G. D., Song, Y. S., Fukuyama, J., Matsen, F. A.
10.1101/2025.06.16.659977 — Posted: 2025-11-20
Targeting peptide-MHC complexes with designed T cell receptors and antibodies
Motmaen, A., Jude, K. M., Wang, N., Minervina, A., Feldman, D., Lichtenstein, M. A., Ebenezer, A., Correnti, C., Thomas, P. G., Garcia, K. C., Baker, D., Bradley, P.
10.1101/2025.11.19.689381 — Posted: 2025-11-20
RNA switch model for localization and translation of the myelin basic protein mRNA
Topkar, V. V., Wu, V., Ho, L. T., Ambiel, N., Valenzuela, A., Yoshimura, K., Zuchero, J. B., Fu, M.-m., Das, R.
10.1101/2025.11.19.689361 — Posted: 2025-11-20
Rapid neocortical network modifications via dendritic plateau potential induced plasticity
Xiao, K., Li, Y., Sullivan, B. J., Li, G., Magee, J. C.
10.1101/2025.11.19.689338 — Posted: 2025-11-19
De novo Design of All-atom Biomolecular Interactions with RFdiffusion3
Butcher, J., Krishna, R., Mitra, R., Brent, R. I., Li, Y., Corley, N., Kim, P. T., Funk, J., Mathis, S. V., Salike, S., Muraishi, A., Eisenach, H., Thompson, T. R., Chen, J., Politanska, Y., Sehgal, E., Coventry, B., Zhang, O., Qiang, B., Didi, K., Kazman, M., DiMaio, F., Baker, D.
10.1101/2025.09.18.676967 — Posted: 2025-11-19
Unconventional linkers facilitate potent stabilized coronavirus stem antibody responses following nanoparticle vaccination
Dzuvor, C. K. O., Moak, S. P., McManus, L. R., Dzordzorme, A. E., Evanson, L. R., Kim, T., Thomas, A., Adeyemi, O., Foley, V., Limaye, A., McNamara, R. P., Corbett-Helaire, K. S.
10.1101/2025.11.19.689216 — Posted: 2025-11-19
Imp1 acts as a dosage- and stage-dependent temporal rheostat orchestrating radial glial fate transitions and cortical morphogenesis
Azur, R. A. G., Feliciano, D., Espinosa-Medina, I., Adhikari, R., Lilao-Garzon, J., Jansen, E., Yang, C.-P., Lee, T.
10.1101/2025.11.18.688993 — Posted: 2025-11-18
Structural Basis for Iterative Methylation by a Cobalamin-dependent Radical S-Adenosylmethionine Enzyme in Cystobactamids Biosynthesis
Cui, J., Wang, B., Maurya, R., Booker, S. J.
10.1101/2025.11.17.688841 — Posted: 2025-11-17
Structure and mechanism of microtubule stabilization and motor regulation by MAP9
Cetin, B., Taheri, A., Golcuk, M., Monroy, B. Y., Fernandes, J., Ori-McKenney, K. M., Gur, M., Nogales, E., Yildiz, A.
10.1101/2025.11.17.688911 — Posted: 2025-11-17
ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment
Qiao, K., Yang, Q.-L., Li, T., Chen, X., Yazgan, Z., Kim, Y. J., Gilbreath, C., Lim, J. Y. S., Xie, Y., Sun, X., Liu, Y., Jia, Y., Chen, Z. J., Huang, H., Wu, S.
10.1101/2025.11.15.688565 — Posted: 2025-11-16

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