Channel:  The Howard Hughes Medical Institute (HHMI)

2,702 Articles

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Triplex formation drives noncontiguous VIPR RNA-guided DNA recognition
Yoon, P. H., Docter, T. A., Zhang, Z., Loi, K. J., Valentin-Alvarado, L. E., Brohawn, S. G., Doudna, J. A.
10.64898/2026.04.26.720927 — Posted: 2026-04-27
TFAM organizes DNA into compact higher order structures
Weerawarana, S. R., Tian, W., Luger, K.
10.64898/2026.04.24.720727 — Posted: 2026-04-27
A Modular Framework for Automated Segmentation and Analysis of AFM Imaging of Chromatin Organization
Sorensen, E. W., Pangeni, S., Merino-Urteaga, R., Murray, P. J., Rudnizky, S., Liao, T.-W., Rashid, F., Hwang, J., Yamadi, M., Feng, X. A., Zähringer, J., Gu, S., Davidson, I. F., Caccianini, L., Osorio-Valeriano, M., Farnung, L., Vos, S., Peters, J.-M., Berger, J. M., Wu, C., Hatzakis, N. S., Kirkegaard, J. B., Ha, T.
10.64898/2026.03.06.708946 — Posted: 2026-04-27
Macronutrient Composition and Genetic Background Determine the Response to a Ketogenic Diet
Zhang, Z., Moura-Assis, A., Liu, S., Millet, A., Shaked, J., Rajan, D., Alwaseem, H., Isay-Del Viscio, M., Molina, H., Birsoy, K., Friedman, J. M.
10.64898/2026.04.23.720368 — Posted: 2026-04-27
Endogenous nucleophilic scavengers of reactive acyl-species neutralize carbon stress
Lee, M.-K., Kim, S. M., Lee, S., Yang, J. H., Choi, C. R., Miao, T., Kim, J.-S., Perrimon, N., Kang, Y. P., Rhee, H.-W.
10.64898/2026.04.06.716549 — Posted: 2026-04-27
Generative design of sequence specific DNA binding proteins
Sehgal, E., Politanska, Y., Mitra, R., Kim, P. T., Gonzalez Rodriguez, N., Warrier, T., Kubaney, A., Morishita, A., Quijano, R., Butcher, J., Krishna, R., Pecoraro, R., Belmont, B., Roullier, N., Goreshnik, I., Vafeados, D. K., Kwon, P., Ramarao, R., Taipale, J., Glasscock, C. J., Baker, D.
10.64898/2026.04.27.720408 — Posted: 2026-04-27
Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis.
Sakers, K., Ramirez, J. J., Elazar, N., Nagendren, L., Soderblom, E. J., Eroglu, C.
10.64898/2025.12.15.694023 — Posted: 2026-04-27
De novo design of a macrocycle induced dimerization system for cellular control
Baker, D., Hanna, S., Salveson, P., Wicky, B., Kennedy, M., Hicks, D., Moller, C., Cheng, S., Li, X., Abedi, M., Coventry, B., Said, M., Bera, A. K., Kang, A., Stoddard, B. L.
10.64898/2026.04.24.720480 — Posted: 2026-04-26
Linking neural representations to behavior using generalization
Nunez-Ochoa, M. A., Du, F., Zhong, L., Baptista, S., Michaelos, M., Sohn, A., Baruchin, L., Schröder, S., Stringer, C., Pachitariu, M.
10.64898/2026.04.21.719991 — Posted: 2026-04-24
Genetic compensation in β-actin mutants occurs independently of mutations that destabilize β-actin mRNA
Saini, H., Zhang, J., Dardari, H., Moazed, D.
10.64898/2026.04.21.719943 — Posted: 2026-04-24

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