Channel:  Aligning Science Across Parkinson's (ASAP)

392 Articles

Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies
Nazeen, S., Wang, X., Zielinski, D., Lam, I., Hallacli, E., Xu, P., Ethier, E., Strom, R., Zanella, C. A., Nithianandam, V., Ritter, D., Henderson, A., Saurat, N., Afroz, J., Nutter-Upham, A., Benyamini, H., Copty, J., Ravishankar, S., Morrow, A., Mitchel, J., Neavin, D., Gupta, R., Farbehi, N., Grundman, J., Myers, R. H., Scherzer, C. R., Trojanowski, J. Q., Van Deerlin, V. M., Cooper, A. A., Lee, E. B., Erlich, Y., Lindquist, S., Peng, J., Geschwind, D. H., Powell, J., Studer, L., Feany, M. B., Sunyaev, S. R., Khurana, V.
10.1101/2024.03.03.583145 — Posted: 2024-03-07
LRRK2 G2019S mutation suppresses differentiation of Th9 and Treg cells via JAK/STAT3
Zheng, N., Jaffery, R., Guerrero, A., Hou, J., Pan, Y., Zhou, F., Chen, S., Xu, C., Egan, N. A., Bohat, R., Chen, K., Schwarzschild, M. A., Chen, X., Peng, W.
10.1101/2024.02.28.582561 — Posted: 2024-03-03
GLP-1 receptor agonism ameliorates Parkinsons disease through modulation of neuronal insulin signalling and glial suppression
Athauda, D., Evans, J. R., Sanchez, L., Virdi, G., Lopez Garcia, P., Wernick, A., Wagen, A., D'Sa, K., Lachica, J., Strohbuecker, S., Vecchi, G., Leighton, C., Saleeb, R. S., OShaughnessy, J., Toomey, C., Vijiaratnam, N., Girges, C., Li, Y., Mustapic, M., Ismail, K., Davies, M., Kapogiannis, D., Choi, M. L., Ryten, M., Horrocks, M. H., Greig, N. H., Foltynie, T., Gandhi, S.
10.1101/2024.02.28.582460 — Posted: 2024-02-28
Adoptive transfer of mitochondrial antigen-specific CD8+ T-cells in mice causes parkinsonism and compromises the dopamine system
Elemeery, M. N., Tchung, A., Boulet, S., Mukherjee, S., Giguere, N., Daudelin, J.-F., Hetu-Arbour, R., Matheoud, D., STRATTON, J. A., Labrecque, N., Trudeau, L.-E.
10.1101/2024.02.26.582098 — Posted: 2024-02-28
Comparative study of enriched dopaminergic neurons from siblings with Gaucher disease discordant for parkinsonism
Hertz, E., Perez, G., Hao, Y., Rytel, K., Ma, C., Kirby, M., Anderson, S., Wincovitch, S., Andersh, K., Ahfeldt, T., Blanchard, J., Qi, Y. A., Lopez, G., Tayebi, N., Sidransky, E., Chen, Y.
10.1101/2024.02.25.581985 — Posted: 2024-02-28
Peripheral Neuronal Activation Shapes the Microbiome and Alters Gut Physiology
Griffiths, J. A., Yoo, B. B., Thuy-Boun, P., Cantu, V., Weldon, K., Challis, C., Sweredoski, M. J., Chan, K. Y., Thron, T. M., Sharon, G., Moradian, A., Humphrey, G., Zhu, Q., Shaffer, J., Wolan, D. W., Dorrestein, P., Knight, R., Gradinaru, V., Mazmanian, S.
10.1101/2021.04.12.439539 — Posted: 2024-02-27
Modeling gene-environment interactions in Parkinson's Disease: Helicobacter pylori infection of Pink1-/- mice induces CD8 T cell-dependent motor and cognitive dysfunction.
Kazanova, A., Sung, J., Oliveira, N. L., Gavino, C., Bessaiah, H., Pei, J., Burns, L., Miller, W., Brouillard-Galipeau, M., Zhu, L., Guerra, L. M., Elemeery, M. N., Recinto, S. J., MacDonald, A., Lanoix, J., Thibault, P., McBride, H. M., Desjardins, M., Stratton, J. A., Labrecque, N., Gruenheid, S.
10.1101/2024.02.25.580545 — Posted: 2024-02-26
Development And Characterization Of A Non-Human Primate Model Of Disseminated Synucleinopathy
Rico, A. J., Corcho, A., Chocarro, J., Ariznabarreta, G., Roda, E., Honrubia, A., Arnaiz Esteban, P., Lanciego, J. L.
10.1101/2023.12.15.571818 — Posted: 2024-02-25
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1
Alvarez Jerez, P., Wild Crea, P. A., Ramos, D., Gustavsson, E. K., Radefeldt, M., Makarious, M. B., Ojo, O. O., Billingsley, K. J., Malik, L., Daida, K., Bromberek, S., Hu, C., Schneider, Z., Surapaneni, A. L., Stadler, J., Rizig, M., Morris, H. R., Pantazis, C. B., Leonard, H. L., Screven, L., Qi, Y. A., Nalls, M. A., Bandres-Ciga, S., Hardy, J., Houlden, H., Eng, C., Gonzalez Burchard, E., Kachuri, L., GP2, , Singleton, A. B., Fischer, S., Bauer, P., Reed, X., Ryten, M., Beetz, C., Ward, M., Okubadejo, N. U., Blauwendraat, C.
10.1101/2024.02.20.24302827 — Posted: 2024-02-24
An axonal brake on striatal dopamine output by cholinergic interneurons
Zhang, Y.-F., Luan, P., Qiao, Q., He, Y., Zatka-Haas, P., Zhang, G., Lin, M., Lak, A., Jing, M., Mann, E. O., Cragg, S.
10.1101/2024.02.17.580796 — Posted: 2024-02-21

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