Channel:  Aligning Science Across Parkinson's (ASAP)

456 Articles

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Alpha-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
Sitron, C. S., Trinkaus, V. A., Galesic, A., Garhammer, M., Yuste Checa, P., Dransfeld, U., Feigenbutz, D., Zhang, J., Dudanova, I., Harper, J. W., Hartl, F. U.
10.1101/2025.01.13.632710 — Posted: 2025-01-15
Experimental and Computational Methods for Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data
Simmons, S. K., Adiconis, X., Haywood, N., Parker, J., Lin, Z., Liao, Z., Tuncali, I., Al'Khafaji, A., Shin, A., Jagadeesh, K., Gosik, K., Gatzen, M., Smith, J. T., El Kodsi, D. N., Kuras, Y., Baecher-Allan, C., Serrano, G. E., Beach, T. G., Garimella, K., Rozenblatt-Rosen, O., Regev, A., Dong, X., Scherzer, C., Levin, J. Z.
10.1101/2024.08.13.607784 — Posted: 2025-01-15
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease
Chou, C.-C., Vest, R., Prado, M. A., Wilson-Grady, J., Paulo, J. A., Shibuya, Y., Moran-Losada, P., Lee, T.-T., Luo, J., Gygi, S. P., Kelly, J. W., Finley, D., Wernig, M., Wyss-Coray, T., Frydman, J.
10.1101/2023.03.27.534444 — Posted: 2025-01-13
Transgenic A53T mice have astrocytic α-synuclein aggregates in dopamine and striatal regions
Peat, C., Prasad, A., Finkelstein, D. I., Sue, C., Johnston, J., Parish, C., Thompson, L., Kirik, D., Halliday, G.
10.1101/2025.01.09.632283 — Posted: 2025-01-12
State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson's disease
Zhai, S., Cui, Q., Wokosin, D., Sun, L., Tkatch, T., Crittenden, J. R., Graybiel, A. M., Surmeier, D. J.
10.1101/2025.01.02.631090 — Posted: 2025-01-07
GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis
Bogacki, E. C., Longmore, G., Lewis, P. A., Herbst, S.
10.1101/2025.01.01.630988 — Posted: 2025-01-01
A single Citrobacter rodentium infection in Pink1 knockout and wild type mice leads to regional blood-brain-barrier perturbation and glial activation without dopamine neuron axon terminal loss
Mukherjee, S., Grouza, V., Tchung, A., Even, A., Yaqubi, M., Tuznik, M., Cannon, T., Recinto, S. J., Gavino, C., Bourque, M.-J., McBride, H. M., Desjardins, M., Gruenheid, S., Stratton, J. A., Rudko, D. A., Trudeau, L.-E.
10.1101/2024.12.24.630165 — Posted: 2024-12-24
Neuronal alpha-Synuclein Disease stage progression over five years
Simuni, T., Gochanour, C., Nair, A. R., Brumm, M. C., Coffey, C., Poston, K. L., Chahine, L. M., Weintraub, D., Tanner, C. M., Gonzalez-Latapi, P., Kopil, C. M., Xiao, Y., Chowdhury, S., Dam, T., Pagano, G., Stephenson, D., Siderowf, A., Dunn, B., Marek, K., on behalf of the Parkinsons Progression Markers Initiative
10.1101/2024.12.17.24319172 — Posted: 2024-12-23
Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson's disease
Gaertner, Z., Oram, C., Schneeweis, A., Schonfeld, E., Bolduc, C., Chen, C., Dombeck, D. A., Parisiadou, L., Poulin, J. F., Awatramani, R.
10.1101/2024.06.06.597807 — Posted: 2024-12-22
Anxa1+ dopamine neuron vulnerability defines prodromal Parkinson's disease bradykinesia and procedural motor learning impairment
Mantas, I., Contestabile, A., Skara, V., Loiseau, C., Santos, I., Cramb, K., Filograna, R., Wade-Martins, R., Magill, P., Meletis, K.
10.1101/2024.12.22.629963 — Posted: 2024-12-22

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