Channel:  Aligning Science Across Parkinson's (ASAP)

541 Articles

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Sst+ GPi output neurons provide direct feedback to key nodes of the basal ganglia and drive behavioral flexibility.
Weglage, M., Aehrlund Richter, S., Contestabile, A., Skara, V., Fuzik, J., Santos, I., Lazaridis, I., Meletis, K.
10.1101/2022.03.16.484460 — Posted: 2025-10-30
Extracellular space diffusion modelling identifies distinct functional advantages of archetypical glutamatergic and GABAergic synapse geometries
Gimenez, P., Shakya, R. T., Santamaria, F., Tonnesen, J.
10.1101/2025.10.29.685288 — Posted: 2025-10-29
The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosis
Mahoney-Sanchez, L., Clarke-Lucas, H., Penverne, A., Evans, J. R., D'Sa, K., Strohbuecker, S., Lopex Garcia, P., Cosker, K., Soltic, D., O'Callaghan, B. J., Griffiths, A., Pintchovski, S. A., Plun-Favreau, H., Hallqvist, J., Mills, K., Gandhi, S.
10.1101/2025.10.13.682089 — Posted: 2025-10-14
Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress
Ehses, K. L., Lopez-Alonso, J. P., Antico, O., Azem, A., Muqit, M., Ubarretxena-Belandia, I., Fernandez-Busnadiego, R.
10.1101/2025.10.06.680693 — Posted: 2025-10-06
Programmable self-assembling system to model intracellular protein aggregation and decode neurodegenerative diseases
Fan, Y., Hoang, J., Steele, C., Benchetrit, Y., Dutta, S., Coughlin, G., Appling, N., Ding, X., Lin, C., Qu, Z., Mackey, E. D., Gradinaru, V.
10.1101/2025.03.06.641009 — Posted: 2025-10-06
Polygenic risk scores and Parkinson's disease in South Africa: Moving towards ancestry-informed disease prediction
Step, K., Ndong Sima, C. A. A., Grant, S., Kim, J. J., Waldo, E., Bardien, S., Mata, I., Global Parkinson's Genetics Program
10.1101/2025.09.29.25336747 — Posted: 2025-09-30
Fall frequency, Risk Factors, and Outcomes in Parkinson's disease: A Cross-Sectional Analysis
Vizcarra, J. A., Hefter, K., Lafontant, D.-E., Duong, M. T., Ertefaie, A., Litt, B., Bassett, D. S., Siderowf, A., The Parkinson's Progression Markers Initiative
10.1101/2025.08.05.25332959 — Posted: 2025-09-25
Faecalibacterium prausnitzii, depleted in the Parkinson's disease microbiome, improves motor deficits in α-synuclein overexpressing mice
Moiseyenko, A., Antonello, G., Schonhoff, A. M., Boktor, J. C., Long, K., Dirks, B., Oguienko, A. D., Winnett, A. V., Simpson, P., Daeizadeh, D., Ismagilov, R. F., Krajmalnik-Brown, R., Segata, N., Waldron, L. D., Mazmanian, S. K.
10.1101/2025.09.18.677192 — Posted: 2025-09-21
A molecular atlas of cell-type specific signatures in the parkinsonian striatum.
Graziano, M., Mantas, I., Masarapu, Y., Frapard, S., Garza, R., Adami, A., Fazal, S., Quaegebeur, A., Barker, R., Jakobsson, J., Giacomello, S., Meletis, K.
10.1101/2025.09.09.675138 — Posted: 2025-09-10
TDP-43 loss of function drives aberrant splicing in Parkinson's disease
Brenton, J. W., Follett, J., Nirujogi, R., Toomey, C. E., Lopez-Garcia, P., Evans, J. R., Lee, Y. J., Syed, K. M., Rocamora Perez, G., Fairbrother-Browne, A., D'Sa, K., Grant-Peters, M., Lachica, J., Hicks, A. R., Wagen, A. Z., O'Callaghan, B., Macpherson, H., Montgomery, K.-a., Busquets, O., Reynolds, R. H., Garcia Ruiz, S., Cao, T., Chen, Z., Plun-Favreau, H., Wong, P. C., Farrer, M., Lashley, T., Soldner, F., Hockemeyer, D., Alessi, D., Wood, N. W., Hardy, J., Rio, D. C., Jaunmuktane, Z., Gustavsson, E. K., Gandhi, S., Ryten, M.
10.1101/2025.09.04.673943 — Posted: 2025-09-09

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