Channel:  Aligning Science Across Parkinson's (ASAP)

392 Articles

Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal Parvalbumin interneurons
Lin, Y.-E., Jaimon, E., Tonelli, F., Pfeffer, S. R.
10.1101/2024.06.17.599289 — Posted: 2024-06-25
Decreased cellular excitability of pyramidal tract neurons in primary motor cortex leads to paradoxically increased network activity in simulated parkinsonian motor cortex
Doherty, D. W., Chen, L., Smith, Y., Wichmann, T., Chu, H.-y., Lytton, W. W.
10.1101/2024.05.23.595566 — Posted: 2024-06-23
Dissociation of novel open loop from ventral putamen to motor areas from classic closed loop in humans II: task-based function
Dundon, N. M., Rizor, E., Stasiak, J., Wang, J., Sabugo, K., Villaneuva, C., Barandon, P., Bostan, A. C., Lapate, R. C., Grafton, S. T.
10.1101/2024.06.18.599622 — Posted: 2024-06-22
Transcriptional pathobiology and multi-omics predictors for Parkinson's disease
Hu, R., Wang, R., Yuan, J., Lin, Z., Hutchins, E., Landin, B., Liao, Z., Liu, G., Scherzer, C. R., Dong, X.
10.1101/2024.06.18.599639 — Posted: 2024-06-21
Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson's disease
Sah, S., Sauerbeck, A. D., Gupta, J., Perez-Acuna, D., Reiber, J. E., Russell, D., Goralski, T., Henderson, M., Volpicelli-Daley, L. A., Higley, M. J., Kummer, T. T., Biederer, T.
10.1101/2024.06.20.599774 — Posted: 2024-06-21
Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2
Chen, S., Basiashvili, T., Hutchings, J., Murillo, M. S., Suarez, A. V., Louro, J. A., Leschziner, A. E., Villa, E.
10.1101/2024.06.18.599606 — Posted: 2024-06-20
Network nature of ligand-receptor interactions underlies disease comorbidity in the brain
Grant-Peters, M., Fairbrother-Browne, A., Hicks, A., Guo, B., Reynolds, R. H., Huuki-Myers, L. A., Eagles, N., Brenton, J., Garcia-Ruiz, S., Wood, N., Gandhi, S., Martinowich, K., Maynard, K., Collado-Torres, L., Ryten, M.
10.1101/2024.06.15.599140 — Posted: 2024-06-16
Mitochondrial damage triggers concerted degradation of negative regulators of neuronal autophagy
Basak, B., Holzbaur, E. L. F.
10.1101/2024.06.12.598718 — Posted: 2024-06-13
Mitochondrial oxidant stress promotes alpha-synuclein aggregation and spreading in mice with mutated glucocerebrosidase
La Vitola, P., Szego, E. M., Pinto-Costa, R., Rollar, A., Harbachova, E., Schapira, A. H. V., Ulusoy, A., Di Monte, D. A.
10.1101/2024.06.13.598820 — Posted: 2024-06-13
Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain
Bagnoli, E., Lin, Y.-E., Burel, S., Jaimon, E., Antico, O., Themistokleous, C., Nikoloff, J., Morella, I., Watzlawik, J., Fiesel, F., Springer, W., Tonelli, F., Brooks, S., Dunnett, S., Brambilla, R., Alessi, D. R., Pfeffer, S. R., Muqit, M.
10.1101/2024.06.11.598416 — Posted: 2024-06-11

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