Channel:  Francis Crick Institute

1,215 Articles

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Substrate heterogeneity promotes cancer cell dissemination through interface roughening
Dunajova, Z., Tasciyan, S., Majek, J., Merrin, J., Sahai, E., Sixt, M., Hannezo, E.
10.1101/2025.05.20.655037 — Posted: 2025-09-25
Chaperone AIP Couples mTORC1 Activation and Catabolic Metabolism During Neonatal Development
Korbonits, M., Wang, X., Barry, S., Lim, C. T., Suleyman, O., De Tito, S., Uddin, N. B., Vignola, M. L., Hall, C., Perna, L., Chapple, P., Henson, S., Morales, V., Bianchi, K., Edvardsson, V. O., Ragnarsson, K. A., Kristinsdottir, V. E., Debeer, A., Sleyp, Y., Zinchenko, R. A., Anderson, G., Duchen, M., Singh, K., Chung, C.-Y., Yuan, Y., Patel, S., Aksoy, E., Borovikov, A., Bjornsson, H. T., Van Esch, H., Czibik, G., Tooze, S., Brennan, C. H., Haworth, O.
10.1101/2025.09.18.677011 — Posted: 2025-09-24
Peptide molecular glues select between BET paralogues by exploiting allosteric sites and conformational dynamics
Patel, K., Mohanty, B., Norman, A., Franck, C., Pachl, P., Yang, L., Jing, X., Reid, X. J., Walshe, J. L., Solomon, P., Tran, D. H., Ford, D., Low, J. K. K., Wilkinson-White, L., Passioura, T., Payne, R. J., Suga, H., Walport, L. J., Mackay, J. P.
10.1101/2025.09.24.678353 — Posted: 2025-09-24
Distinct ATRX functions cooperate with 9-1-1 and CST complexesto safeguard replication and telomere integrity
Segura-Bayona, S., Maric, M., Takaki, T., Manova, Z., Li, S., Stanage, T. H., Idilli, A. I., Hewitt, G., Ruis, P., Millar, R., Patel, H., Howell, S., Kotsantis, P., Howell, M., Boulton, S. J.
10.1101/2025.09.22.677761 — Posted: 2025-09-22
Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation
Olthof, A. M., Gonzalez, M. N., Poulsen, N. B., Moreno, N. N., Bautu, T., Cugusi, S., Svejstrup, J.
10.1101/2025.09.18.677100 — Posted: 2025-09-18
Conserved Aberrant Developmental Trajectories of Human and Mouse SBMA Motor Neurons
Devine, H., Roberts, M. J., Ziff, O. J., Hanna, M. G., Greensmith, L., Patani, R., Malik, B.
10.1101/2025.09.17.674754 — Posted: 2025-09-17
Mechanisms for cross-neutralisation of diverse bat sarbecoviruses
Upadhyay, A., Seow, J., Alguel, Y., Newman, J., Thakur, N., Hay, A., Tam, J. C. H., Nans, A., Orton, R., Bailey, D., Cherepanov, P., Doores, K. J.
10.1101/2025.09.17.674891 — Posted: 2025-09-17
Characterisation of LAMP1- and LAMP2A-positive organelles in neurons
Abouward, R., Abdelhafid, A. M., Wilkins, O. G., Lee, S.-Y., Ibrahim, F., Skehel, M., Ting, A., Birsa, N., Ule, J., Schiavo, G.
10.1101/2025.09.17.676809 — Posted: 2025-09-17
Morphogen and juxtacrine signalling dynamically integrate to specify cell fates with single-cell resolution
Donoghue, A., Mosby, L., Lago-Baldaia, I., Hodgetts, T., Ursu, E., Erten, Z., Hadjivasiliou, Z., Fernandes, V. M.
10.1101/2025.09.15.676088 — Posted: 2025-09-17
Cell migration sculpts evolutionary dynamics favouring therapy resistance in lung cancer
Bhargava, A., Fu, X., Bailey, S., Naito, Y., Mohammadi, H., Hynds, R. E., Hooper, S., Biswas, D., Le Marois, A., Kumar, S., Alexandrov, Y., French, P. M., McGinty, J., Bates, P. A., Swanton, C., Sahai, E.
10.1101/2025.09.15.675999 — Posted: 2025-09-16

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