Channel:  The Howard Hughes Medical Institute (HHMI)

2,491 Articles

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Broadly neutralizing antibodies against emerging delta-coronaviruses
Rexhepaj, M., Park, Y.-J., Perruzza, L., Asarnow, D., McCallum, M., Culap, K., Saliba, C., Leoni, G., Balmeli, A., Yoshiyama, C., Dickinson, M. S., Quispe, J., Brown, J. T., Tortorici, M. A., Sprouse, K. R., Taylor, A. L., Starr, T. N., Corti, D., Begnini, F., Veesler, D.
10.1101/2024.03.27.586411 — Posted: 2024-04-01
Directed Evolution of Acoustic Reporter Genes Using High-Throughput Acoustic Screening
Hurt, R. C., Jin, Z., Soufi, M., Wong, K. K., Sawyer, D. P., Shen, H. K., Dutka, P., Deshpande, R., Zhang, R., Mittelstein, D. R., Shapiro, M. G.
10.1101/2024.03.30.587094 — Posted: 2024-04-01
NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis
Parolia, A., Eyunni, S., Verma, B. K., Young, E., Liu, L., George, J., Aras, S., Das, C. K., Mannan, R., ur Rasool, R., Luo, J., Carson, S. E., Mitchell-Velasquez, E., Liu, Y., Xiao, L., Gajjala, P. R., Jaber, M., Wang, X., He, T., Qiao, Y., Pang, M., Zhang, Y., Alhusayan, M., Cao, X., Tavana, O., Hou, C., Wang, Z., Ding, K., Chinnaiyan, A. M., Asangani, I. A.
10.1101/2024.02.22.581560 — Posted: 2024-03-29
How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimers disease brain by a strain-relief mechanism
Hou, K., Ge, P., Sawaya, M. R., Dolinsky, J. L., Yang, Y., Jiang, Y. X., Lutter, L., Boyer, D. R., Cheng, X., Pi, J., Zhang, J., Lu, J., Yang, S., Yu, Z., Feigon, J., Eisenberg, D. S.
10.1101/2024.03.25.586668 — Posted: 2024-03-29
Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancers
Tang, J., Weiser, N. E., Wang, G., Chowdhry, S., Curtis, E. J., Zhao, Y., Wong, I. T.-L., Marinov, G. K., Li, R., Hanoian, P., Tse, E., Hansen, R., Plum, J., Steffy, A., Milutinovic, S., Meyer, S. T., Altemose, N., Curtis, C., Greenleaf, W. J., Bafna, V., Benkovic, S. J., Pinkerton, A. B., Kasibhatla, S., Hassig, C. A., Mischel, P. S., Chang, H. Y.
10.1101/2024.03.29.586681 — Posted: 2024-03-29
The Molecular Architecture of the Nuclear Basket
Singh, D., Soni, N., Hutchings, J., Echeverria, I., Shaikh, F., Duquette, M., Suslov, S., Li, Z., van Eeuwen, T., Molloy, K., Shi, Y., Wang, J., Guo, Q., Chait, B. T., Fernandez-Martinez, J., Rout, M. P., Sali, A., Villa, E.
10.1101/2024.03.27.587068 — Posted: 2024-03-28
Expanding the genetics and phenotypes of ocular congenital cranial dysinnervation disorders
Jurgens, J. A., Barry, B. J., Chan, W.-M., MacKinnon, S., Whitman, M. C., Matos Ruiz, P. M., Pratt, B. M., England, E. M., Pais, L., Lemire, G., Groopman, E., Glaze, C., Russell, K. A., Singer-Berk, M., Di Gioia, S. A., Lee, A. S., Andrews, C., Shaaban, S., Wirth, M. M., Bekele, S., Toffoloni, M., Bradford, V. R., Foster, E. E., Berube, L., Rivera-Quiles, C., Mensching, F. M., Sanchis-Juan, A., Fu, J. M., Wong, I., Zhao, X., Wilson, M. W., Weisburd, B., Lek, M., Ocular CCDD Phenotyping Consortium, , Brand, H., Talkowski, M. E., MacArthur, D. G., O'Donnell-Luria, A., Robson, C. D., Hunter, D.
10.1101/2024.03.22.24304594 — Posted: 2024-03-26
A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan
Jayne, L., Lavin-Peter, A., Roessler, J., Tyshkovskiy, A., Antoszewski, M., Ren, E., Markovski, A., Sun, S., Yao, H., Sankaran, V. G., Gladyshev, V. N., Brooke, R. T., Horvath, S., Griffith, E. C., Hrvatin, S.
10.1101/2024.03.20.585828 — Posted: 2024-03-25
CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality
Tien, J. C.-Y., Chang, Y., Zhang, Y., Chou, J., Cheng, Y., Wang, X., Yang, J., Mannan, R., Shah, P., Wang, X.-M., Todd, A. J., Eyunni, S., Cheng, C., Rebernick, R. J., Xiao, L., Bao, Y., Neiswender, J., Brough, R., Pettitt, S. J., Cao, X., Miner, S. J., Zhou, L., Wu, Y.-M., Labanca, E., Wang, Y., Parolia, A., Cieslik, M., Robinson, D. R., Wang, Z., Feng, F. Y., Lord, C. J., Ding, K., Chinnaiyan, A. M.
10.1101/2024.03.20.585990 — Posted: 2024-03-21
PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes
Singh, S., Dransfeld, U., Ambaw, Y., Lopez-Scarim, J., Farese, R. V., Walther, T. C.
10.1101/2024.03.21.586175 — Posted: 2024-03-21

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