Channel:  The Howard Hughes Medical Institute (HHMI)

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Tuning Insulin Receptor Signaling Using De Novo Designed Agonists
Wang, X., Cardoso, S., Cai, K., Venkatesh, P., Hung, A., Ng, M., Hall, C., Coventry, B., Lee, D., Chowhan, R., Gerben, S., Li, J., An, W., Hon, M., Accili, D., Bai, X., Choi, E., Baker, D.
10.1101/2024.10.07.617068 — Posted: 2024-10-11
Value construction through sequential sampling explains serial dependencies in decision making
Zylberberg, A., Bakkour, A., Shohamy, D., Shadlen, M. N.
10.1101/2024.01.13.575363 — Posted: 2024-10-11
A collection of split-Gal4 drivers targeting conserved signaling ligands in Drosophila
Ewen-Campen, B., Joshi, N., Herman, A. S., Thakkar, T., Zirin, J., Perrimon, N.
10.1101/2024.10.10.617664 — Posted: 2024-10-11
2.6-A resolution cryo-EM structure of a class Ia ribonucleotide reductase trapped with mechanism-based inhibitor N3CDP
Westmoreland, D. E., Feliciano, P. R., Kang, G., Cui, C., Kim, A., Stubbe, J., Nocera, D. G., Drennan, C. L.
10.1101/2024.10.09.617422 — Posted: 2024-10-10
Deep mutational scanning identifies variants of Cas1 and Cas2 that increase spacer acquisition in type II-A CRISPR-Cas systems
Hofmann, R., Herman, C., Mo, C., Mathai, J., Marraffini, L. A.
10.1101/2024.10.10.617623 — Posted: 2024-10-10
Heterozygous and generalist MxA super-restrictors overcome breadth-specificity tradeoffs in antiviral restriction
Geiger, R. A., Khera, D., Tenthorey, J., Kochs, G., Graf, L., Emerman, M., Malik, H. S.
10.1101/2024.10.10.617484 — Posted: 2024-10-10
DNA Polymerase Locks Replication Fork Under Stress
Jia, X., Inman, J. T., Singh, A., Patel, S. S., Wang, M. D.
10.1101/2024.10.09.617451 — Posted: 2024-10-10
Torsional Mechanics of Circular DNA
Singh, G., Hong, Y., Inman, J. T., Sethna, J. P., Wang, M. D.
10.1101/2024.10.08.617281 — Posted: 2024-10-10
Hidden evolutionary constraints dictate the retention of coronavirus accessory genes
Goldstein, S. A., Feeley, T. M., Babler, K. M., Hilbert, Z. A., Downhour, D. M., Moshiri, N., Elde, N. C.
10.1101/2023.10.12.561935 — Posted: 2024-10-09
Independent effects of testosterone, estradiol, and sex chromosomes on gene expression in immune cells of trans- and cisgender individuals
Harris, R. M., Whitfield, T., Blanton, L. V., Skaletsky, H., Blumen, K., Hyland, P., McDermott, E., Summers, K., Hughes, J. F., Jackson, E., Teglas, P., Liu, B., Chan, Y.-M., Page, D. C.
10.1101/2024.10.08.617275 — Posted: 2024-10-09

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