Channel:  Babraham Institute

154 Articles

Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain
Lemaitre, P., Tareen, S., Pasciuto, E., Mascali, L., Martirosyan, A., Callaerts-Vegh, Z., Dooley, J., Holt, M., Yshii, L., Liston, A.
10.1101/2022.03.01.482519 — Posted: 2022-03-04
Polypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells
D'Angeli, V., Monzon-Casanova, E., Matheson, L. S., Gizlenci, O., Petkau, G., Gooding, C., Berrens, R. V., Smith, C. W. J., Turner, M.
10.1101/2022.03.03.482829 — Posted: 2022-03-04
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation
Yshii, L., Pasciuto, E., Bielefeld, P., Mascali, L., Lemaitre, P., Marino, M., Dooley, J., Kouser, L., Verschoren, S., Lagou, V., Kemps, H., Gervois, P., de Boer, A., Burton, O., Wahis, J., Tareen, S., Roca, C., Singh, K., Whyte, C., Kerstens, A., Callaerts-Vegh, Z., Poovathingal, S., Prezzemolo, T., Wierda, K., Dashwood, A., Xie, J., Van Wonterghem, E., Creemers, E., Aloulou, M., Gsell, W., Abiega, O., Munck, S., Vandenbroucke, R., Lemmens, R., De Strooper, B., Van Den Bosch, L., Himmelreich, U., Fitzsimons, C. P., Holt, M., Liston, A.
10.1101/2022.02.28.482297 — Posted: 2022-03-02
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
Chondronasiou, D., Gill, D., Mosteiro, L., Urdinguio, R. G., Berenguer, A., Aguilera, M., Durand, S., Aprahamian, F., Nirmalathasan, N., Abad, M., Martin-Herranz, D. E., Stephan-Otto Attolini, C., Prats, N., Kroemer, G., Fraga, M. F., Reik, W., Serrano, M.
10.1101/2022.01.20.477063 — Posted: 2022-01-21
H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeller function
Li, J., Bergmann, L., Rafael de Almeida, A., Webb, K. M., Gogol, M. M., Voigt, P., Liu, Y., Liang, H., Smolle, M. M.
10.1101/2021.02.26.432832 — Posted: 2022-01-20
Plasma cell maintenance and antibody secretion are under the control of Sec22b-mediated regulation of organelle dynamics
Bonaud, A., Gargowitsch, L., Gilbert, S., Rajan, E., Canales-Herrerias, P., Stockholm, D., Rahman, N., Collins, M., Hill, D. L., Alloatti, A., Alouche, N., Balor, S., Soldan, V., Gillet, D., Barbier, J., Bachelerie, F., Smith, K. G. C., Bruhns, P., Amigorena, S., Balabanian, K., Linterman, M. A., Peden, A., Espeli, M.
10.1101/2022.01.14.476154 — Posted: 2022-01-15
Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function
Ravichandran, M., Rafalski, D., Ortega-Recalde, O., Davies, C. I., Glanfield, C. R., Kotter, A., Misztal, K., Wang, A. H., Wojciechowski, M., Razew, M., Mayyas, I. M., Kardailsky, O., Schwarz, U., Zembrzycki, K., Morison, I. M., Helm, M., Weichenhan, D., Jurkowska, R. Z., Krueger, F., Plass, C., Zacharias, M., Hore, T. A., Bochtler, M., Jurkowski, T. P.
10.1101/2021.12.29.474486 — Posted: 2021-12-30
Single-Cell Atlas of Common Variable Immunodeficiency reveals germinal center-associated epigenetic dysregulation in B cell responses
Rodriguez-Ubreva, J., Arutyunyan, A., Bonder, M. J., Del Pino-Molina, L., Clark, S., de la Calle-Fabregat, C., Garcia-Alonso, L., Handfield, L.-F., Ciudad, L., Andres-Leon, E., Krueger, F., Catala-Moll, F., Rodriguez-Cortez, V. C., Polanski, K., Mamanova, L., van Dongen, S., Kiselev, V. Y., Martinez-Saavedra, M. T., Heyn, H., Martin, J., Warnatz, K., Lopez-Granados, E., Rodriguez-Gallego, C., Stegle, O., Kelsey, G. D., Vento-Tormo, R., Ballestar, E.
10.1101/2021.12.20.473453 — Posted: 2021-12-21
GwEEP - A comprehensive approach for genome-wide efficiency profiling of DNA modifying enzymes
Kyriakopoulos, C., Nordström, K., Kramer, P. L., Gottfreund, J., Salhab, A., Arand, J., Müller, F., von Meyenn, F., Ficz, G., Reik, W., Wolf, V., Walter, J., Giehr, P.
10.1101/2020.08.06.236307 — Posted: 2021-11-25
The distinct effects of MEK and GSK3 inhibition upon the methylome and transcriptome of mouse embryonic stem cells
Spindel, J., Krueger, C., Krueger, F., Papachristou, E. K., Kishore, K., D'Santos, C. S., Reik, W.
10.1101/2021.11.18.469000 — Posted: 2021-11-18

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