Channel:  Aligning Science Across Parkinson's (ASAP)

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

246 Articles

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
Malik, A. U., Karapetsas, A., Nirujogi, R. S., Chatterjee, D., Phung, T. K., Wightman, M., Gourlay, R., Morrice, N., Mathea, S., Knapp, S., Alessi, D. R.
10.1101/2022.06.09.495448 — Posted: 2022-08-17
Structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Choi, M. L., Chappard, A., Singh, B. P., Maclachlan, C., Rodrigues, M., Fedotova, E., Berezhnov, A., De, S., Peddie, C., Athauda, D., Virdi, G. S., Zhang, W., Evans, J. R., Wernick, A., Zanjani, Z., Angelova, P. R., Esteras, N., Andrey, A., Morris, K., Jeacock, K., Tosatto, L., Little, D., Gissen, P., Collinson, L., Clarke, D. J., Kunath, T., Klenerman, D., Abramov, A. Y., Horrocks, M. H., Gandhi, S.
10.1101/2022.06.07.494932 — Posted: 2022-06-09
Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms
Wallen, Z. D., Demirkan, A., Twa, G., Cohen, G., Dean, M. N., Standaert, D. G., Sampson, T., Payami, H.
10.1101/2022.06.08.495316 — Posted: 2022-06-12
Basal Ganglia Neurons in Healthy and Parkinsonian Primates Generate Recurring Sequences of Spikes
Galvan, A., Wichmann, T.
10.1101/2022.05.25.493476 — Posted: 2022-05-26
Synaptic Location Is a Determinant of the Detrimental Effects of alpha-Synuclein Pathology to Glutamatergic Transmission in the Basolateral Amygdala
Chen, L., Nagaraja, C., Daniels, S., Fisk, Z. A., Dvorak, R., Meyerdirk, L., Steiner, J. A., Galvis, M. L. E., Henderson, M., Rousseaux, M., Brundin, P., Chu, H.-y.
10.1101/2022.02.20.481207 — Posted: 2022-06-30
Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling
Harding, O., Holzbaur, E. L. F.
10.1101/2022.06.21.496850 — Posted: 2022-06-22
Dopaminergic axons track somatic signaling in behaving mice
Azcorra, M., Gaertner, Z., Davidson, C., Ramakrishnan, C., Fenno, L., Kim, Y. S., Deisseroth, K., Awatramani, R., Dombeck, D. A.
10.1101/2022.06.20.496872 — Posted: 2022-06-22
Sst+ GPi output neurons provide direct feedback to key nodes of the basal ganglia and drive behavioral flexibility.
Weglage, M., Aehrlund Richter, S., Skara, V., Lazaridis, I., Meletis, K.
10.1101/2022.03.16.484460 — Posted: 2022-03-18
Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation
Ren, X., Nguyen, T. N., Lam, W. K., Buffalo, C. Z., Lazarou, M., Yokom, A. L., Hurley, J. H.
10.1101/2022.07.12.499634 — Posted: 2022-07-13
Integrated multi-cohort analysis of the Parkinson's disease gut metagenome
Boktor, J. C., Sharon, G., Verhagen Metman, L. A., Hall, D. A., Engen, P. A., Zreloff, Z., Hakim, D. J., Bostick, J. W., Ousey, J., Lange, D., Humphrey, G., Ackermann, G., Carlin, M., Knight, R., Keshavarzian, A., Mazmanian, S. K.
10.1101/2022.07.20.500694 — Posted: 2022-07-21

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