Channel:  Francis Crick Institute

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

925 Articles

Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst
Simon, C. S., McCarthy, A., Woods, L., Staneva, D., Huang, Q., Linneberg-Agerholm, M., Faulkner, A., Papathanasiou, A., Elder, K., Snell, P., Christie, L., Garcia, P., Shaikly, V., Taranissi, M., Choudhary, M., Herbert, M., Brickman, J. M., Niakan, K. K.
10.1101/2024.02.01.578414 — Posted: 2024-02-04
Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites.
Koussis, K., Haase, S., Withers-Martinez, C., Flynn, H. R., Kunzelmann, S., Christodoulou, E., Ibrahim, F., Skehel, M., Baker, D. A., Blackman, M. J.
10.1101/2024.02.04.578801 — Posted: 2024-02-04
Force-transducing molecular ensembles at growing microtubule tips control mitotic spindle size
Chu, L.-Y., Stedman, D., Gannon, J., Cox, S., Pobegalov, G., Molodtsov, M.
10.1101/2024.02.01.578443 — Posted: 2024-02-02
m6a methylation orchestrates IMP1 regulation of microtubules during human neuronal differentiation
Klein, P., Harley, J., Crook, H., Serna, S. E., Petric-Howe, M., Roumeliotis, T. I., Choudhary, J. S., Chakrabarti, A. M., Luisier, R., Patani, R., Ramos, A.
10.1101/2023.09.12.557394 — Posted: 2024-02-02
Combining RASG12C(ON) inhibitor with SHP2 inhibition sensitises immune excluded lung tumours to immune checkpoint blockade: a strategy for turning cold tumours hot
Anastasiou, P., Moore, C., Rana, S., de Castro, A., Tomaschko, M., Boumelha, J., Mugarza, E., Blaj, C., de Carne Trecesson, S., Goldstone, R., Smith, J., Quintana, E., Molina-Arcas, M., Downward, J.
10.1101/2024.01.15.575765 — Posted: 2024-01-30
The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir
Dinh, T., Tber, Z., Rey, J. S., Mengshetti, S., Annamalai, A. S., Haney, R., Briganti, L., Amblard, F., Fuchs, J. R., Cherepanov, P., Kim, K., Schinazi, R. F., Perilla, J. R., Kim, B., Kvaratskhelia, M.
10.1101/2024.01.26.577387 — Posted: 2024-01-26
Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of oesophageal cancer
Ganguli, P., Colomina-Basanta, C., Mendez, A., Armero-Pineiro, M., Zahra, A., Acha-Sagrado, A., Misetic, H., Devonshire, G., Kelly, G., Freeman, A., Green, M., Nye, E., Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, , Rodriguez-Justo, M., Spencer, J., Fitzgerald, R. C., Ciccarelli, F. D.
10.1101/2024.01.24.576991 — Posted: 2024-01-26
Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential prior to implantation in the mouse
Kruger, R., Frum, T., Brumm, A. S., Hickey, S. L., Niakan, K., Aziz, F., Shammami, M., Roberts, J., Ralston, A.
10.1101/2024.01.23.576717 — Posted: 2024-01-24
Mechanism of chaperone coordination during cotranslational protein folding in bacteria
Roeselova, A., Maslen, S. L., Shivakumaraswamy, S., Pellowe, G. A., Howell, S., Joshi, D., Redmond, J., Kjaer, S., Skehel, M., Balchin, D.
10.1101/2024.01.22.576655 — Posted: 2024-01-23
ImmCellTyper: an integrated computational pipeline for systematic mining of Mass Cytometry data to assist deep immune profiling
Sun, J., Choy, D., Sompairac, N., Jamshidi, S., Mishto, M., Kordasti, S.
10.1101/2024.01.15.575790 — Posted: 2024-01-17

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