bioRxiv is receiving many new papers on coronavirus SARS-CoV-2.   A reminder: these are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information.

Channel : Francis Crick Institute

489 Articles

Identification of SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of the nsp14 RNA Cap Methyltransferase
Basier, C., Basu, S., Beale, R., Canal, B., Cowling, V. H., Curran, J. F., Deegan, T. D., Diffley, J. F., Drury, L. S., Fujisawa, R., Howell, M., Labib, K., Lim, C. T., Mak, T., McClure, A. W., Roberts, E., Tan, K. W., Ulferts, R., Weissmann, F., Wu, M., Zeisner, T. U.
10.1101/2021.04.07.438810 — Posted: 2021-04-08
Oncogenic RAS activity predicts response to chemotherapy and outcome in lung adenocarcinoma
East, P., Kelly, G., Biswas, D., Marani, M., Hancock, D. C., Creasy, T., Sachsenmeier, K., Swanton, C., de Carne Trecesson, S., Downward, J.
10.1101/2021.04.02.437896 — Posted: 2021-04-04
Common ALS/FTD risk variants in UNC13A exacerbate its cryptic splicing and loss upon TDP-43 mislocalization
Brown, A.-L., Wilkins, O. G., Keuss, M. J., Hill, S. E., Zanovello, M., Lee, W. C., Lee, F. C. Y., Masino, L., Qi, Y. A., Bryce-Smith, S., Bampton, A., Gatt, A., Phatnani, H., NYGC ALS Consortium, , Schiavo, G., Fisher, E. M. C., Raj, T., Secrier, M., Lashley, T., Ule, J., Buratti, E., Humphrey, J., Ward, M. E., Fratta, P.
10.1101/2021.04.02.438170 — Posted: 2021-04-04
A SIMPLI (Single-cell Identification from MultiPLexed Images) approach for spatially resolved tissue phenotypingat single-cell resolution.
Bortolomeazzi, M., Montorsi, L., Temelkovski, D., Keddar, M. R., Acha-Sagredo, A., Pitcher, M. J., Basso, G., Laghi, L., Rodriguez-Justo, M., Spencer, J., Ciccarelli, F. D.
10.1101/2021.04.01.437886 — Posted: 2021-04-02
In vitro teratogenicity testing using a 3D, embryo-like gastruloid system
Mantziou, V., Baillie-Benson, P., Jaklin, M., Kustermann, S., Martinez Arias, A., Moris, N.
10.1101/2021.03.30.437698 — Posted: 2021-03-30
Biallelic mutations in cancer genomes reveal local mutational determinants
Demeulemeester, J., Dentro, S. C., Gerstung, M., Van Loo, P.
10.1101/2021.03.29.437407 — Posted: 2021-03-30
Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients.
Sposito, B., Broggi, A., Pandolfi, L., Crotta, S., Ferrarese, R., Sisti, S., Clementi, N., Ambrosi, A., Liu, E., Frangipane, V., Saracino, L., Marongiu, L., Facchini, F., Bottazzi, A., Fossali, T., Colombo, R., Clementi, M., Tagliabue, E., Pontiroli, A., Meloni, F., Wack, A., Mancini, N., Zanoni, I.
10.1101/2021.03.30.437173 — Posted: 2021-03-30
TRIM28-dependent SUMOylation protects the adult ovary from the male pathway
Rossitto, M., Dejardin, S., Rands, C. M., Legras, S., Migale, R., Rafiee, M.-R., Neirijnck, Y., Pruvost, A., Nguyen, A. L., Bossis, G., Cammas, F. M., Le Gallic, L., Wilhelm, D., Boizet-Bonhoure, B., Lovell-Badge, R., Nef, S., Poulat, F.
10.1101/2021.03.24.436749 — Posted: 2021-03-24
N-myristoyltransferase inhibition is synthetic lethal in MYC-deregulated cancers
Lueg, G. A., Faronato, M., Gorelik, A., Goya Grocin, A., Caamano-Gutierrez, E., Falciani, F., Solari, R., Carr, R., Bell, A. S., Bartlett, E., Hutton, J. A., Llorian-Sopena, M., Chakravarty, P., Brzezicha, B., Janz, M., Garnett, M. J., Calado, D. P., Tate, E. W.
10.1101/2021.03.20.436222 — Posted: 2021-03-20
ChromWave: Deciphering the DNA-encoded competition between transcription factors and nucleosomes with deep neural networks
Cakiroglu, S. A., Steinhauser, S., Smith, J., Xing, W., Luscombe, N. M.
10.1101/2021.03.19.436198 — Posted: 2021-03-20

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