Channel:  Francis Crick Institute

1,187 Articles

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Genome-wide Chromosome-specific Aneuploidy Engineering and Phenotypic Characterization with CRISPR-Taiji
Feng, H., Deng, D., Dahiya, R., Wang, L., Zeng, J., Tan, B. J. Y., Byrne, F., Shepherd, S. T. C., Wang, J., Johnson, S. C., Harrod, A., Lane, K. A., Fendler, A., Cattin, A.-L., Tippu, Z., Nie, M., Zhao, Y., Wang, R., Ai, W., Bouricha, O., Barber, T., Dovga, Y., Xu, Y., Shen, W., Sun, Z., Wang, H., Zhu, J., Xu, Y., Devito, L. G., Healy, L., Lim, E. S., OToole, S. M., Akker, S., Drake, W. M., Jin, H., Downs, J. A., McClelland, S. E., Diffley, J. F. C., Ly, P., Turajlic, S.
10.1101/2025.04.25.650684 — Posted: 2025-10-18
VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment
Calderon, R. I., Sah, N., Huang, M., Kallol, S., Kittle, R. H., Shaik, W., Abdelaal, A., Chousal, J. N., Morey, R., Bui, T., Mitre, A., Fogarty, N. M. E., Gerri, C., Manalo, Z., Zheng, C., DeHoff, P. M., Home, P., Niakan, K., Cook-Andersen, H., Fisch, K. M., Paul, S., Soncin, F.
10.1101/2025.04.25.650693 — Posted: 2025-10-15
The origin and molecular evolution of the mammalian liver cell architecture
Yuan, X., Rodriguez-Montes, L., Zaremba, B., Trost, N., Schneider, C., Schmidt, J., Berki, B., Ibberson, D., Leushkin, E., Nickel, B., Palkovits, M., Truman, R. W., Barsh, G., Lees, J., Fallahshahroudi, A., Grützner, F., Tzika, A. C., Milinkovitch, M. C., Pääbo, S., Cardoso-Moreira, M., Kaessmann, H.
10.1101/2025.10.14.682049 — Posted: 2025-10-14
Extensive and differential platinum chemotherapy mutagenesis in children
Wenger, A., Lee-Six, H., Dave, M., Layeghifard, M., Lawson, A. R. J., Abascal, F., Nicola, P. A., Treger, T. D., Ogbonnah, T., Parks, C., Oliver, T. R. W., Kennedy, J., Hodder, A., Anderson, N. D., Silva, F. L. T., Trinh, M. K., Dowe, T., Habarwaa, M., Sun, J. J., Assia-Zamora, S., Cortes-Cerisuelo, M., Jassem, W., Town, C., Dhawan, A., Jain, V., Straathof, K., Deheragoda, M., Martincorena, I., Palm, L., Hutchinson, J. C., Coorens, T. H. H., Trayers, C., Heaton, N., Shlien, A., Zen, Y., Rouhani, F. J., Behjati, S.
10.1101/2025.10.12.681852 — Posted: 2025-10-14
The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosis
Mahoney-Sanchez, L., Clarke-Lucas, H., Penverne, A., Evans, J. R., D'Sa, K., Strohbuecker, S., Lopex Garcia, P., Cosker, K., Soltic, D., O'Callaghan, B. J., Griffiths, A., Pintchovski, S. A., Plun-Favreau, H., Hallqvist, J., Mills, K., Gandhi, S.
10.1101/2025.10.13.682089 — Posted: 2025-10-14
Ecological cues orchestrate concerted courtship in a Drosophila host specialist
Brand, P., Keller, K., Coleman, R. T., Eghbali, N. B., Zylka, S., Prieto-Godino, L. L., Ruta, V.
10.1101/2025.10.13.681913 — Posted: 2025-10-14
Cell cycle oscillations in a polarity network facilitate state switching by morphogenetic cues
Ng, K., Sebaa, H., Hirani, N., Chizh, A., Messi, Z., Bland, T., Sugioka, K., Goehring, N. W.
10.1101/2025.10.12.681824 — Posted: 2025-10-13
Inactivation of Airborne Pathogen Surrogates by Triethylene Glycol
Desai, G., Goldman, E., Jordan, W., Balarashti, J., Caravanos, J., Edgar, R. S., Grignard, E., Ramachandran, G., Mainelis, G.
10.1101/2025.08.08.669335 — Posted: 2025-10-08
Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction
Pulschen, A. A., Booth, J., Satanowski, A., Soudy, C., Caro-Astorga, J., Ather, O., Patel, N., Alidoust, A., Aoudjane, S., Nematollahi, L., DeBenedictis, E.
10.1101/2025.10.08.681035 — Posted: 2025-10-08
DNMT3A-R882 mutations intrinsically drive dysfunctional neutropoiesis from human haematopoietic stem cells
Mantica, G., Vedi, A., Tuval, A., Huerga Encabo, H., Hayler, D., Krzywon, A., Mitchell, E., Dunn, W. G., Biezuner, T., Bastos, H. P., Sham, K., Santoro, A., Lee, J., Williams, N., Danin, A., Chapal, N., Moskovitz, Y., Arruda, A., Fiorillo, E., Orru, V., Marongiu, M., McKinney, E., Cucca, F., Collin, M., Minden, M., Campbell, P., Vassiliou, G. S., Fabre, M. A., Nangalia, J., Bonnet, D., Shlush, L., Laurenti, E.
10.1101/2025.10.08.679225 — Posted: 2025-10-08

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