Channel:  The Howard Hughes Medical Institute (HHMI)

2,708 Articles

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Viral SSB-bound ssDNA activates the bacterial anti-phage defense system DARNA
Puteikiene, R., Vassallo, C., Silanskas, A., Juozapaitis, J., Songailiene, I., Laub, M. T., Sasnauskas, G.
10.64898/2026.02.22.705581 — Posted: 2026-02-23
Reprogramming CAR T-Cells with designed bioPROTACs
Peche, V. S., Kenny, S., Kang, T. G., Coventry, B., Mi, T., Goreshnik, I., Garcia Sanchez, M., Martin, R., Smith, M., Vafeados, D., Kathayat, R., Kaiwen, Y., Yuan, Z.-F., Wu, L., High, A., Nemecek, A., Wickmann, E., Adeshakin, A., Ferrara, F., Throm, R., Chen, T., Youngblood, B., Baker, D., Gottschalk, S.
10.64898/2026.02.21.706835 — Posted: 2026-02-22
A neofunctionalized flowering antagonist created an evolutionary contingency that channeled Solanaceae adaptation
Shohat, H., Ciren, D., Arrones, A., Gentile, I., Ramakrishnan, S., Hendelman, A., Jenike, K. M., Brown, N. L., Luna-Ramos, J., Passalacqua, M. J., Satterlee, J. W., Fitzgerald, B., Baraja-Fonseca, V., Robitaille, G. M., Seman, B. M., Gillis, J., Van Eck, J., Prohens, J., Schatz, M. C., Lippman, Z. B.
10.64898/2026.02.20.707063 — Posted: 2026-02-21
Husbandry and Maintenance of Carausius morosus Laboratory Populations
Ingersoll, M., Kovacikova, P., Hashmi, Y., Extavour, C. G.
10.64898/2026.02.19.706905 — Posted: 2026-02-20
Donor-specific assemblies enhance somatic structural variant detection in complex genomic regions
Mack, T. M., Lin, J., Ren, L., Sohn, M.-H., Minkina, A., Kwon, Y., Yoo, D., Sui, Y., Munson, K. M., Hoekzema, K., Mastrorosa, F. K., Sorensen, M., Ayllon, M., Sun, K. A., Koundiya, N., Ou, J., Noyes, M. D., Sedeno-Cortes, A., Leonardson, A., Jacques, C. N., Oliviera, C., Frazar, C. D., Zakarian, C., Jensen, D. M., Swanson, E. G., Ryke, E., Kolar, J. T., Ranchalis, J., Sutherlin, L., Vollger, M. R., Loy, K., Pham, M. M., Huang, M.-F., Au, N. Y., Nielsen, P. M., McGee, S. R., Neph, S., Bohaczuk, S., Shaffer, T., Freeman, V., Mao, Y., Cohen Stillman, B., Richardson, M., Smith, J. D., Weiss, J. M.
10.64898/2026.02.20.707061 — Posted: 2026-02-20
Mechanistic machine learning enables interpretable and generalizable prediction of prime editing outcomes
Hsu, A., Chen, P. J., Li, A. H., Hemez, C. F., Gao, X. D., Terrey, M., Nelson, C., Selvam, V., Cristian, A., McElroy, A. N., Steinbeck, B. J., Mahadeshwar, G. K., Pandey, S., Barsdale, Z., Chen, P. Z., Sousa, A. A., Sakai, H. A., Silverstein, R. A., Morad, I., Krueger, R. K., Shen, M. W., Kleinstiver, B. P., Lutz, C. M., Tolar, J., Blazar, B. R., Osborne, M., Liu, D.
10.64898/2026.02.20.706353 — Posted: 2026-02-20
An in planta single-cell screen to accelerate functional genetics
Lowensohn, T. N., Cody, W. B., Tsai, C., Vlahos, A. E., Call, C. C., Gao, X. J., Sattely, E. S.
10.1101/2025.08.06.668818 — Posted: 2026-02-19
Asymmetric Histone Inheritance Regulates Olfactory Stem Cell Fates During Regeneration
Ma, B., Yang, G., Yao, J., Wu, C., Vega, J. P., Manske, G., Sue, H., Sinha, S., Singh, A., Zhao, H., Chen, X.
10.1101/2025.03.02.641101 — Posted: 2026-02-19
A conserved C. elegans zinc finger-homeodomain protein, ZFH-2, continuously required for structural integrity and function of alimentary tract and gonad
Sussfeld, A., Vidal, B., Sural, S., Merritt, D. M., Aguilar, G. R., Ramadan, Y., Hobert, O.
10.64898/2026.01.13.699069 — Posted: 2026-02-19
Phage display-mediated immuno-PCR to detect low-abundance secreted proteins in Drosophila
Han, M., Xia, B., Kim, A.-R., Filine, E., Stoneburner, E., Miao, T., Liu, Y., Zirin, J., Perrimon, N.
10.1101/2025.10.31.685841 — Posted: 2026-02-19

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