Channel:  The Howard Hughes Medical Institute (HHMI)

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The Platinum Pedigree: A long-read benchmark for genetic variants
Kronenberg, Z., Nolan, C., Mokveld, T., Rowell, W. J., Lee, S., Dolzhenko, E., Chang, P.-C., Holt, J. M., Saunders, C. T., Olson, N. D., McGee, S., Guarracino, A., Koundinya, N., Harvey, W. T., Watkins, W. S., Munson, K. M., Hoekzema, K., Chua, K. P., Fanslow, C., Lambert, C., Dashnow, H., Garrison, E., Smith, J., Lansdorp, P., Zook, J. M., Carroll, A., Jorde, L. B., Neklason, D. W., Quinlan, A., Eichler, E., Eberle, M. A.
10.1101/2024.10.02.616333 — Posted: 2024-10-03
New Statistical Metric for Robust Target Detection in Cryo-EM Using 2DTM
Zhang, K., Cossio, P., Rangan, A. V., Lucas, B. A., Grigorieff, N.
10.1101/2024.10.01.616095 — Posted: 2024-10-03
Multi-laboratory Study Establishes Reproducible Methods for Plant-Microbiome Research in Fabricated Ecosystems
Novak, V., Andeer, P. F., King, E., Calabria, J., Fitzpatrick, C., Kelm, J. M., Wippel, K., Kosina, S. M., Daum, C., Zane, M., Yadav, A., Chen, M., Russ, D., Adams, C. A., Owens, T. K., Lee, B., Ding, Y., Sordo, Z., Chakraborty, R., Roux, S., Deutschbauer, A. M., Ushizima, D., Zengler, K., Arsova, B., Dangl, J., Schulze-Lefert, P., Watt, M., Vogel, J., Northen, T. R.
10.1101/2024.10.02.615924 — Posted: 2024-10-03
Engineered Whole Lungs for Tissue Biology
Greaney, A. M., Raredon, M. S. B., Obata, T., Wang, J., Adams, T. S., Schupp, J. C., Mizoguchi, S., Edelstein, S., Yuan, Y., Baevova, P., Wang, N., Engler, A., Leiby, K., Tsuchiya, T., Homer, R., Kaminski, N., Langer, R., Niklason, L., Medzhitov, R.
10.1101/2024.10.02.616240 — Posted: 2024-10-03
Rapid two-step target capture ensures efficient CRISPR-Cas9-guided genome editing
Shi, H., Al-Sayyad, N., Wasko, K., Trinidad, M. I., Doherty, E. E., Vohra, K., Boger, R. S., Colognori, D., Cofsky, J. C., Skopintsev, P., Bryant, Z., Doudna, J. A.
10.1101/2024.10.01.616117 — Posted: 2024-10-02
Remote activation of place codes by gaze in a highly visual animal
Payne, H. L., Aronov, D.
10.1101/2024.09.30.615982 — Posted: 2024-10-02
Cell-type-informed genotyping of mosaic focal epilepsies reveals cell-autonomous and non-cell-autonomous disease-associated transcriptional programs
Bizzotto, S., Stronge, E. A., Talukdar, M., Hu, Q., Zhou, Z., Huang, A. Y., Chhouk, B. H., D'Gama, A. M., Yang, E., Green, T. E., Reutens, D. C., Mullen, S. A., Hildebrand, M. S., Buono, R. J., Poduri, A. H., Khoshkhoo, S., Walsh, C. A.
10.1101/2024.10.01.615793 — Posted: 2024-10-02
Diversified, miniaturized and ancestral parts for mammalian genome engineering and molecular recording
McDiarmid, T. A., Taylor, M. L., Chen, W., Chardon, F. M., Choi, J., Liao, H., Li, X., Kim, H., Lalanne, J.-B., Li, T., Nathans, J. F., Martin, B. K., Knuth, J., Coradini, A. L. V., Gray, J. M., Pinglay, S., Shendure, J.
10.1101/2024.09.30.615957 — Posted: 2024-10-01
An aneuploidy epistasis map reveals metabolic vulnerabilities associated with supernumerary chromosomes in cancer
Magesh, R. Y., Kaur, A. N., Keller, F. N., Frederick, A., Tseyang, T., Haley, J. A., Rivera Nieves, A. M., Liang, A. C., Guertin, D., Spinelli, J., Elledge, S. J., Watson, E. V.
10.1101/2024.09.30.615609 — Posted: 2024-10-01
Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells
Grzywa, T., Mehta, N., Cossette, B., Romanov, A., Paruzzo, L., Ramasubramanian, R., Cozzone, A., Morgan, D., Sukaj, I., Bergaggio, E., Tannir, R., Kadauke, S., Myers, R., Yousefpour, P., Ghilardi, G., Schuster, S., Neeser, A., Frey, N., Goncalves, B., Zhang, L., Abraham, W., Suh, H., Ruella, M., Grupp, S., Chiarle, R., Wittrup, K. D., Ma, L., Irvine, D. J.
10.1101/2024.04.16.589780 — Posted: 2024-10-01

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