Channel:  Aligning Science Across Parkinson's (ASAP)

528 Articles

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LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology spread
Lubben, N., Brynildsen, J. K., Leyns, C. E. G., Webb, C. M., Li, H. L., Changolkar, L., Zhang, B., Meymand, E., O'Reilly, M., Madaj, Z., DeWeerd, D., Fell, M. J., Lee, V. M. Y., Bassett, D. S., Henderson, M. X.
10.1101/2023.10.06.561190 — Posted: 2023-10-06
Parkinsons VPS35 mutation induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B
Pal, P., Taylor, M., Lam, P. Y., Tonelli, F., Hecht, C. A., Lis, P., Nirujogi, R. S., Phung, T. K., Dickie, E. A., Wightman, M., Macartney, T., Pfeffer, S. R., Alessi, D. R.
10.1101/2023.06.07.544051 — Posted: 2023-10-03
Structural pathway for class III PI 3-kinase activation by the myristoylated GTP-binding pseudokinase VPS15
Cook, A. S. I., Chen, M. H., Ren, X., Rao, S., Garcia, S. N., Claveras Cabezudo, A., Iavarone, A. T., Hummer, G., Hurley, J. H.
10.1101/2023.09.28.559894 — Posted: 2023-09-28
Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD
Adriaenssens, E., Nguyen, T. N., Sawa-Makarska, J., Khuu, G., Schuschnig, M., Shoebridge, S., Watts, E. M., Csalyi, K. D., Padman, B. S., Lazarou, M., Martens, S.
10.1101/2023.09.25.559255 — Posted: 2023-09-25
Neuromelanin accumulation drives endogenous synucleinopathy in non-human primates
Chocarro, J., Rico, A. J., Ariznabarreta, G., Roda, E., Honrubia, A., Collantes, M., Penuelas, I., Vazquez, A., Rodriguez-Perez, A. I., Labandeira-Garcia, J. L., Vila Bover, M., Lanciego, J. L.
10.1101/2023.08.04.551615 — Posted: 2023-09-20
Parkinson's genes orchestrate pyroptosis through selective trafficking of mtDNA to leaky lysosomes
Nguyen, M., Collier, J. J., Ignatenko, O., Morin, G., Huang, S., Desjardins, M., McBride, H. M.
10.1101/2023.09.11.557213 — Posted: 2023-09-12
Inhibition of Parkinsons Disease-related LRRK2 by type-I and type-II kinase inhibitors: activity and structures
Leschziner, A. E., Sanz Murillo, M., Suarez, A. V., Dederer, V., Chatterjee, D., Louro, J. A., Knapp, S., Mathea, S.
10.1101/2023.09.07.556689 — Posted: 2023-09-09
Gut mucosal cells transfer alpha-synuclein to the vagus nerve
Chandra, R., Sokratian, A., Chavez, K. R., King, S., Swain, S. M., Snyder, J. C., West, A. B., Liddle, R. A.
10.1101/2023.08.14.553305 — Posted: 2023-09-05
A RAB7A Phosphoswitch Coordinates Rubicon Homology Protein Regulation of PINK1/Parkin-Dependent Mitophagy
Tudorica, D. A., Basak, B. L. F., Cordova, A. P., Khuu, G., Rose, K., Lazarou, M., Holzbaur, E., Hurley, J. H.
10.1101/2023.08.28.555228 — Posted: 2023-08-29
Membrane remodeling properties of the Parkinson's disease protein LRRK2
Wang, X., Espadas, J., Wu, Y., Cai, S., Ge, J., Shao, L., Roux, A., De Camilli, P.
10.1101/2022.08.10.503505 — Posted: 2023-08-26

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