Channel:  Aligning Science Across Parkinson's (ASAP)

503 Articles

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Parkinson's genes orchestrate pyroptosis through selective trafficking of mtDNA to leaky lysosomes
Nguyen, M., Collier, J. J., Ignatenko, O., Morin, G., Huang, S., Desjardins, M., McBride, H. M.
10.1101/2023.09.11.557213 — Posted: 2023-09-12
Inhibition of Parkinsons Disease-related LRRK2 by type-I and type-II kinase inhibitors: activity and structures
Leschziner, A. E., Sanz Murillo, M., Suarez, A. V., Dederer, V., Chatterjee, D., Louro, J. A., Knapp, S., Mathea, S.
10.1101/2023.09.07.556689 — Posted: 2023-09-09
Gut mucosal cells transfer alpha-synuclein to the vagus nerve
Chandra, R., Sokratian, A., Chavez, K. R., King, S., Swain, S. M., Snyder, J. C., West, A. B., Liddle, R. A.
10.1101/2023.08.14.553305 — Posted: 2023-09-05
A RAB7A Phosphoswitch Coordinates Rubicon Homology Protein Regulation of PINK1/Parkin-Dependent Mitophagy
Tudorica, D. A., Basak, B. L. F., Cordova, A. P., Khuu, G., Rose, K., Lazarou, M., Holzbaur, E., Hurley, J. H.
10.1101/2023.08.28.555228 — Posted: 2023-08-29
Membrane remodeling properties of the Parkinson's disease protein LRRK2
Wang, X., Espadas, J., Wu, Y., Cai, S., Ge, J., Shao, L., Roux, A., De Camilli, P.
10.1101/2022.08.10.503505 — Posted: 2023-08-26
Neither alpha-synuclein-preformed fibrils derived from patients with GBA1 mutations nor the host murine genotype significantly influence seeding efficacy in the mouse olfactory bulb.
Killinger, B., Kordower, J. H., Walton, S., Fenyi, A., Tittle, T., Choi, S., Sidransky, E., Paul, G., Melki, R.
10.1101/2023.08.24.554646 — Posted: 2023-08-25
M4-mediated cholinergic transmission is reduced in parkinsonian mice and its restoration alleviates motor deficits and levodopa-induced dyskinesia
Nielsen, B. E., Ford, C. P.
10.1101/2023.08.23.554510 — Posted: 2023-08-24
iATPSnFR2: a high dynamic range fluorescent sensor for monitoring intracellular ATP
Marvin, J. S., Kokotos, A. C., Kumar, M., Pulido, C., Tkachuk, A. N., Yao, J. S., Brown, T. A., Ryan, T. A.
10.1101/2023.08.24.554624 — Posted: 2023-08-24
Functional characterization of ATP13A2 variants associated with distinct neurodegenerative disorders
Vrijsen, S., El Asrar, R. A., Houdou, M. C., Van den Haute, C., Baekelandt, V., Lyons, J. A., Eggermont, J., Vangheluwe, P.
10.1101/2023.08.21.552829 — Posted: 2023-08-21
A leaky gut dysregulates gene networks in the brain associated with immune activation, oxidative stress, and myelination in a mouse model of colitis
Boles, J. S., Krueger, M., Jernigan, J., Cole, C., Neighbarger, N., Huarte, O. U., Tansey, M. G.
10.1101/2023.08.10.552488 — Posted: 2023-08-13

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