Channel:  Aligning Science Across Parkinson's (ASAP)

425 Articles

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A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation
Vides, E. G., Adhikari, A., Chiang, C. Y., Lis, P., Purlyte, E., Limouse, C., Shumate, J. L., Lasso, E. S., Dhekne, H. S., Alessi, D. R., Pfeffer, S. R.
10.1101/2022.04.25.489459 — Posted: 2022-09-22
Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD model.
Morrone Parfitt, G., Coccia, E., Goldman, C., Whitney, K., Reyes, R., Sarrafha, L., Nam, K. H., Sohail, S., Jones, D., crary, J. F., Ordureau, A., Blanchard, J., Ahfeldt, T. D.
10.1101/2022.08.26.505472 — Posted: 2022-09-08
LRRK2-G2019S SYNERGIZES WITH AGEING AND LOW-GRADE INFLAMMATION TO PROMOTE GUT AND PERIPHERAL IMMUNE CELL ACTIVATION THAT PRECEDE NIGROSTRIATAL DEGENERATION
Giachino, C., Tirolo, C., Caniglia, S., Serapide, M. F., L'Episcopo, F., Bertoli, F., Giuliano, C., Mearelli, M., Jakobi, M., Schneiderhan-Marra, N., Deleidi, M., Marchetti, B.
10.1101/2022.09.01.505977 — Posted: 2022-09-03
PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
Malik, A. U., Karapetsas, A., Nirujogi, R. S., Chatterjee, D., Phung, T. K., Wightman, M., Gourlay, R., Morrice, N., Mathea, S., Knapp, S., Alessi, D. R.
10.1101/2022.06.09.495448 — Posted: 2022-08-17
In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson's disease
Gonzalez-Sepulveda, M., Compte, J., Cuadros, T., Nicolau, A., Guillard-Sirieix, C., Penuelas, N., Lorente-Picon, M., Parent, A., Romero-Gimenez, J., Cladera-Sastre, J. M., Laguna, A., Vila, M.
10.1101/2022.08.08.503142 — Posted: 2022-08-11
Impact of 100 LRRK2 variants linked to Parkinsons Disease on kinase activity and microtubule binding
Kalogeropulou, A. F., Purlyte, E., Tonelli, F., Lange, S. M., Wightman, M., Prescott, A. R., Padmanabhan, S., Sammler, E., Alessi, D. R.
10.1101/2022.04.01.486724 — Posted: 2022-08-10
Multi-ancestry genome-wide meta-analysis in Parkinson's disease
Kim, J. J., Vitale, D., Veliz-Otani, D., Lian, M., Heilbron, K., the 23andMe Research Team, , Iwaki, H., Lake, J., Solsberg, C. W., Leonard, H., Makarious, M. B., Tan, E.-K., Singleton, A. B., Bandres-Ciga, S., Noyce, A. J., Blauwendraat, C., Nalls, M. A., Foo, J. N., Mata, I.
10.1101/2022.08.04.22278432 — Posted: 2022-08-06
Is Tau the Initial Pathology in Dopaminergic Nigrostriatal Degeneration? Studies in Parkinsonism and Parkinson ' Disease
Chu, Y., Hirst, W. D., Federoff, H. J., Harms, A. S., Stoessl, A. J., Kordower, J. H.
10.1101/2022.08.04.502831 — Posted: 2022-08-06
Nicotine-mediated rescue of α-synuclein toxicity requires synaptic vesicle glycoprotein 2
Olsen, A. L., Clemens, S. G., Feany, M. B.
10.1101/2022.07.26.501592 — Posted: 2022-07-28
Large-scale biophysically detailed model of somatosensory thalamocortical circuits in NetPyNE
Borges, F. d. S., Moreira, J. V. S., Takarabe, L. M., Lytton, W. W., Dura-Bernal, S.
10.1101/2022.02.03.479029 — Posted: 2022-07-28

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