Channel:  Aligning Science Across Parkinson's (ASAP)

505 Articles

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Reduction of a-synuclein aggregates by PIKfyve inhibition via TFEB-mediated lysosomal biogenesis in a Parkinson disease model
Lucas-Del-Pozo, S., Uras, G., Fierli, F., Lentini, V., Koletsi, S., Chau, K.-Y., Hughes, D., Schapira, A. H.
10.1101/2023.10.23.563557 — Posted: 2023-10-24
Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production
Bennett, N. K., Lee, M., Orr, A. L., Nakamura, K.
10.1101/2023.10.14.562276 — Posted: 2023-10-18
A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy
Nebuloni, F., Do, Q., Cook, P. R., Walsh, E., Wade-Martins, R.
10.1101/2023.10.14.562004 — Posted: 2023-10-17
Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons
Mohd Rafiq, N., Fujise, K., Rosenfeld, M., Xu, P., Wu, Y., De Camilli, P.
10.1101/2023.10.12.562142 — Posted: 2023-10-13
Phosphoglycerate kinase 1 is a central leverage point in Parkinson's disease driven neuronal metabolic deficits
Kokotos, A., Antoniazzi, A., Unda, S., Kokotos, M. S., Park, D., Eliezer, D., Kaplitt, M., De Camilli, P., Ryan, T.
10.1101/2023.10.10.561760 — Posted: 2023-10-10
A topographical atlas of alpha-Synuclein dosage and cell-type expression in the mouse brain and periphery
Geertsma, H. M., Fisk, Z. A., Sauline, L., Prigent, A., Kurgat, K., Callaghan, S. M., aSCENT PD Consortium, , Henderson, M., Rousseaux, M. W. C.
10.1101/2023.10.05.559770 — Posted: 2023-10-07
Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging
Nithianandam, V., Bukhari, H., Leventhal, M. J., Battaglia, R. A., Dong, X., Fraenkel, E., Feany, M. B.
10.1101/2023.10.06.560646 — Posted: 2023-10-07
LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology spread
Lubben, N., Brynildsen, J. K., Leyns, C. E. G., Webb, C. M., Li, H. L., Changolkar, L., Zhang, B., Meymand, E., O'Reilly, M., Madaj, Z., DeWeerd, D., Fell, M. J., Lee, V. M. Y., Bassett, D. S., Henderson, M. X.
10.1101/2023.10.06.561190 — Posted: 2023-10-06
Parkinsons VPS35 mutation induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B
Pal, P., Taylor, M., Lam, P. Y., Tonelli, F., Hecht, C. A., Lis, P., Nirujogi, R. S., Phung, T. K., Dickie, E. A., Wightman, M., Macartney, T., Pfeffer, S. R., Alessi, D. R.
10.1101/2023.06.07.544051 — Posted: 2023-10-03
Structural pathway for class III PI 3-kinase activation by the myristoylated GTP-binding pseudokinase VPS15
Cook, A. S. I., Chen, M. H., Ren, X., Rao, S., Garcia, S. N., Claveras Cabezudo, A., Iavarone, A. T., Hummer, G., Hurley, J. H.
10.1101/2023.09.28.559894 — Posted: 2023-09-28

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