Channel:  Aligning Science Across Parkinson's (ASAP)

392 Articles

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
Malik, A. U., Karapetsas, A., Nirujogi, R. S., Chatterjee, D., Phung, T. K., Wightman, M., Gourlay, R., Morrice, N., Mathea, S., Knapp, S., Alessi, D. R.
10.1101/2022.06.09.495448 — Posted: 2022-08-17
In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson's disease
Gonzalez-Sepulveda, M., Compte, J., Cuadros, T., Nicolau, A., Guillard-Sirieix, C., Penuelas, N., Lorente-Picon, M., Parent, A., Romero-Gimenez, J., Cladera-Sastre, J. M., Laguna, A., Vila, M.
10.1101/2022.08.08.503142 — Posted: 2022-08-11
Impact of 100 LRRK2 variants linked to Parkinsons Disease on kinase activity and microtubule binding
Kalogeropulou, A. F., Purlyte, E., Tonelli, F., Lange, S. M., Wightman, M., Prescott, A. R., Padmanabhan, S., Sammler, E., Alessi, D. R.
10.1101/2022.04.01.486724 — Posted: 2022-08-10
Multi-ancestry genome-wide meta-analysis in Parkinson's disease
Kim, J. J., Vitale, D., Veliz-Otani, D., Lian, M., Heilbron, K., the 23andMe Research Team, , Iwaki, H., Lake, J., Solsberg, C. W., Leonard, H., Makarious, M. B., Tan, E.-K., Singleton, A. B., Bandres-Ciga, S., Noyce, A. J., Blauwendraat, C., Nalls, M. A., Foo, J. N., Mata, I.
10.1101/2022.08.04.22278432 — Posted: 2022-08-06
Is Tau the Initial Pathology in Dopaminergic Nigrostriatal Degeneration? Studies in Parkinsonism and Parkinson ' Disease
Chu, Y., Hirst, W. D., Federoff, H. J., Harms, A. S., Stoessl, A. J., Kordower, J. H.
10.1101/2022.08.04.502831 — Posted: 2022-08-06
Nicotine-mediated rescue of α-synuclein toxicity requires synaptic vesicle glycoprotein 2
Olsen, A. L., Clemens, S. G., Feany, M. B.
10.1101/2022.07.26.501592 — Posted: 2022-07-28
Large-scale biophysically detailed model of somatosensory thalamocortical circuits in NetPyNE
Borges, F. d. S., Moreira, J. V. S., Takarabe, L. M., Lytton, W. W., Dura-Bernal, S.
10.1101/2022.02.03.479029 — Posted: 2022-07-28
Cell type directed design of synthetic enhancers
Taskiran, I. I., Spanier, K. I., Christiaens, V., Mauduit, D., Aerts, S.
10.1101/2022.07.26.501466 — Posted: 2022-07-27
Integrated multi-cohort analysis of the Parkinson's disease gut metagenome
Boktor, J. C., Sharon, G., Verhagen Metman, L. A., Hall, D. A., Engen, P. A., Zreloff, Z., Hakim, D. J., Bostick, J. W., Ousey, J., Lange, D., Humphrey, G., Ackermann, G., Carlin, M., Knight, R., Keshavarzian, A., Mazmanian, S. K.
10.1101/2022.07.20.500694 — Posted: 2022-07-21
Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation
Ren, X., Nguyen, T. N., Lam, W. K., Buffalo, C. Z., Lazarou, M., Yokom, A. L., Hurley, J. H.
10.1101/2022.07.12.499634 — Posted: 2022-07-13

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