Channel:  Aligning Science Across Parkinson's (ASAP)

392 Articles

Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology
Ng, X. Y., Wu, Y., Lin, Y., Yaqoob, S. M., Greene, L. E., De Camilli, P., Cao, M.
10.1101/2022.02.28.482419 — Posted: 2022-11-20
Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes
Dou, D., Smith, E. M., Evans, C. S., Boecker, C. A., Holzbaur, E. L. F.
10.1101/2022.11.14.516471 — Posted: 2022-11-14
Excessive Firing of Dyskinesia-Associated Striatal Direct Pathway Neurons is Gated By Dopamine and Excitatory Synaptic Input
Ryan, M. B., Girasole, A. E., McGregor, M. M., Brakaj, R., Paletzki, R. F., Gerfen, C. R., Nelson, A. B.
10.1101/2022.10.31.514594 — Posted: 2022-11-01
Association of genetic variation at the GJA5/ACP6 locus with motor progression in Parkinson's
Martinez, A., Real, R., Lawton, M., Reynolds, R. H., Tan, M. M., Wu, L., Williams, N., Carroll, C., Corvol, J.-C., Hu, M. T. M., Grosset, D., Hardy, J., shlomo, Y. B., Shoai, M., Morris, H.
10.1101/2022.10.28.22281645 — Posted: 2022-11-01
Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in human midbrain dopaminergic neurons
Virdi, G. S., Choi, M. L., Evans, J. R., Yao, Z., Athauda, D., Strohbuecker, S., Wernick, A. I., Alrashidi, H., Melandri, D., Perez-lloret, J., Stroh, P. R., Sylantyev, S., Eaton, S., Heales, S., Kunath, T., Horrocks, M. H., Abramov, A. Y., Patani, R., Gandhi, S.
10.1101/2022.10.28.514238 — Posted: 2022-10-28
Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease
Schonhoff, A. M., Figge, D. A., Jurkuvenaite, A. J., Gallups, N. J., Childers, G. M., Webster, J. A., Standaert, D. G., Goldman, J. E., Harms, A. S.
10.1101/2022.10.12.511960 — Posted: 2022-10-16
Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases
Reynolds, R. H., Wagen, A. Z., Lona-Durazo, F., Scholz, S. W., Shoai, M., Hardy, J., Gagliano Taliun, S. A., Ryten, M.
10.1101/2022.05.30.22275781 — Posted: 2022-10-04
A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation
Vides, E. G., Adhikari, A., Chiang, C. Y., Lis, P., Purlyte, E., Limouse, C., Shumate, J. L., Lasso, E. S., Dhekne, H. S., Alessi, D. R., Pfeffer, S. R.
10.1101/2022.04.25.489459 — Posted: 2022-09-22
Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD model.
Morrone Parfitt, G., Coccia, E., Goldman, C., Whitney, K., Reyes, R., Sarrafha, L., Nam, K. H., Sohail, S., Jones, D., crary, J. F., Ordureau, A., Blanchard, J., Ahfeldt, T. D.
10.1101/2022.08.26.505472 — Posted: 2022-09-08
LRRK2-G2019S SYNERGIZES WITH AGEING AND LOW-GRADE INFLAMMATION TO PROMOTE GUT AND PERIPHERAL IMMUNE CELL ACTIVATION THAT PRECEDE NIGROSTRIATAL DEGENERATION
Giachino, C., Tirolo, C., Caniglia, S., Serapide, M. F., L'Episcopo, F., Bertoli, F., Giuliano, C., Mearelli, M., Jakobi, M., Schneiderhan-Marra, N., Deleidi, M., Marchetti, B.
10.1101/2022.09.01.505977 — Posted: 2022-09-03

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