Channel:  Aligning Science Across Parkinson's (ASAP)

511 Articles

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Alpha-synuclein overexpression can drive microbiome dysbiosis in mice
Sampson, T. R., Wallen, Z. D., Won, W.-J., Standaert, D. G., Payami, H., Harms, A. S.
10.1101/2024.02.01.578464 — Posted: 2024-02-01
KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy
de Talhouet, C., Esteras Gallego, N., Soutar, M. P. M., O'Callaghan, B., Plun-Favreau, H.
10.1101/2023.08.03.551835 — Posted: 2024-01-31
Visualizing chaperone-mediated multistep assembly of the human 20S proteasome
Adolf, F., Du, J., Goodall, E. A., Walsh, R. M., rawson, S., von Gronaua, S., Harper, J. W., Hanna, J., Schulman, B. A.
10.1101/2024.01.27.577538 — Posted: 2024-01-28
Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
Erb, M. L., Sipple, K., Levine, N., Chen, X., Moore, D. J.
10.1101/2024.01.25.577280 — Posted: 2024-01-26
3D Bioprinting of Human Neural Tissues with Functional Connectivity
Yan, Y., Li, X., Gao, Y., Mathivanan, S., Kong, L., Tao, Y., Dong, Y., Li, X., Bhattacharyya, A., Zhao, X., Zhang, S.-C.
10.1101/2024.01.18.576289 — Posted: 2024-01-23
A pathogenic variant in RAB32 causes autosomal dominant Parkinsons disease and activates LRRK2 kinase
Gustavsson, E. K., Follett, J., Trinh, J., Barodia, S. K., Real, R., Liu, Z., Grant-Peters, M., Fox, J. D., Appel-Cresswell, S., Stoessl, J. A., Rajput, A., Rajput, A. H., Auer, R., Tilney, R., Sturm, M., Haack, T. B., Lesage, S., Tesson, C., Brice, A., Vilarino-Gueell, C., Ryten, M., Goldberg, M. S., West, A. B., Hu, M. T., Morris, H. R., Sharma, M., Gan-Or, Z., Samanci, B., Lis, P., Tocino, T., Amouri, R., Ben Sassi, S., Hentati, F., Tonelli, F., Alessi, D. R., Farrer, M. J.
10.1101/2024.01.17.24300927 — Posted: 2024-01-18
Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinsons disease
Khan, S. S., Jaimon, E., Lin, Y.-E., Nikoloff, J., Tonelli, F., Alessi, D. R., Pfeffer, S. R.
10.1101/2024.01.15.575737 — Posted: 2024-01-16
Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency
Nithianadam, V., Sarkar, S., Feany, M. B.
10.1101/2024.01.08.574634 — Posted: 2024-01-08
Mechanism of human PINK1 activation at the TOM complex in a reconstituted system
Raimi, O., Ojha, H., Ehses, K., Dederer, V., Lange, S., Rivera, C. P., Deegan, T., Chen, Y., Wightman, M., Toth, R., Labib, K., Mathea, S., Ranson, N., Fernandez-Busnadiego, R., Muqit, M.
10.1101/2023.12.23.573181 — Posted: 2024-01-02
Spatial genomics of AAVs reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo
Coughlin, G. M., Borsos, M., Appling, N., Barcelona, B. H., Mayfield, A. M. H., Mackey, E. D., Eser, R. A., Chen, X., Kumar, S. R., Gradinaru, V.
10.1101/2023.12.23.573214 — Posted: 2023-12-24

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