Channel:  Aligning Science Across Parkinson's (ASAP)

390 Articles

Association of genetic variation at the GJA5/ACP6 locus with motor progression in Parkinson's
Martinez, A., Real, R., Lawton, M., Reynolds, R. H., Tan, M. M., Wu, L., Williams, N., Carroll, C., Corvol, J.-C., Hu, M. T. M., Grosset, D., Hardy, J., shlomo, Y. B., Shoai, M., Morris, H.
10.1101/2022.10.28.22281645 — Posted: 2022-11-01
Excessive Firing of Dyskinesia-Associated Striatal Direct Pathway Neurons is Gated By Dopamine and Excitatory Synaptic Input
Ryan, M. B., Girasole, A. E., McGregor, M. M., Brakaj, R., Paletzki, R. F., Gerfen, C. R., Nelson, A. B.
10.1101/2022.10.31.514594 — Posted: 2022-11-01
Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in human midbrain dopaminergic neurons
Virdi, G. S., Choi, M. L., Evans, J. R., Yao, Z., Athauda, D., Strohbuecker, S., Wernick, A. I., Alrashidi, H., Melandri, D., Perez-lloret, J., Stroh, P. R., Sylantyev, S., Eaton, S., Heales, S., Kunath, T., Horrocks, M. H., Abramov, A. Y., Patani, R., Gandhi, S.
10.1101/2022.10.28.514238 — Posted: 2022-10-28
Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease
Schonhoff, A. M., Figge, D. A., Jurkuvenaite, A. J., Gallups, N. J., Childers, G. M., Webster, J. A., Standaert, D. G., Goldman, J. E., Harms, A. S.
10.1101/2022.10.12.511960 — Posted: 2022-10-16
Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases
Reynolds, R. H., Wagen, A. Z., Lona-Durazo, F., Scholz, S. W., Shoai, M., Hardy, J., Gagliano Taliun, S. A., Ryten, M.
10.1101/2022.05.30.22275781 — Posted: 2022-10-04
A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation
Vides, E. G., Adhikari, A., Chiang, C. Y., Lis, P., Purlyte, E., Limouse, C., Shumate, J. L., Lasso, E. S., Dhekne, H. S., Alessi, D. R., Pfeffer, S. R.
10.1101/2022.04.25.489459 — Posted: 2022-09-22
Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD model.
Morrone Parfitt, G., Coccia, E., Goldman, C., Whitney, K., Reyes, R., Sarrafha, L., Nam, K. H., Sohail, S., Jones, D., crary, J. F., Ordureau, A., Blanchard, J., Ahfeldt, T. D.
10.1101/2022.08.26.505472 — Posted: 2022-09-08
LRRK2-G2019S SYNERGIZES WITH AGEING AND LOW-GRADE INFLAMMATION TO PROMOTE GUT AND PERIPHERAL IMMUNE CELL ACTIVATION THAT PRECEDE NIGROSTRIATAL DEGENERATION
Giachino, C., Tirolo, C., Caniglia, S., Serapide, M. F., L'Episcopo, F., Bertoli, F., Giuliano, C., Mearelli, M., Jakobi, M., Schneiderhan-Marra, N., Deleidi, M., Marchetti, B.
10.1101/2022.09.01.505977 — Posted: 2022-09-03
PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
Malik, A. U., Karapetsas, A., Nirujogi, R. S., Chatterjee, D., Phung, T. K., Wightman, M., Gourlay, R., Morrice, N., Mathea, S., Knapp, S., Alessi, D. R.
10.1101/2022.06.09.495448 — Posted: 2022-08-17
In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson's disease
Gonzalez-Sepulveda, M., Compte, J., Cuadros, T., Nicolau, A., Guillard-Sirieix, C., Penuelas, N., Lorente-Picon, M., Parent, A., Romero-Gimenez, J., Cladera-Sastre, J. M., Laguna, A., Vila, M.
10.1101/2022.08.08.503142 — Posted: 2022-08-11

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