Channel:  Francis Crick Institute

1,360 Articles

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Lineage-specific retrotransposon co-option reveals a conserved ASH2L isoform as an epigenetic primer of developmental gene promoters
Elgood Hunt, E., Vivori, C., Mitter, R., Hannah Johnkingsly Jebaraj, J., Agnadottir, V., Delas, J., Serna Morales, E., Frith, T., Skehel, M., Elosegui-Artola, A., Briscoe, J., van Werven, F.
10.64898/2026.02.25.707914 — Posted: 2026-05-27
Endolysosomal damage promotes intraluminal protein condensate formation that limits cytosolic leakage
LI, X., Zhang, Y., ZHAO, K., Chen, G., Cui, D., Nikan, M., Young, S., Bennett, F., Seth, P. P., Ni, T., Gutierrez, M. G., Jiang, H.
10.64898/2026.05.25.726725 — Posted: 2026-05-25
Asymmetric Contrastive Objectives for Efficient Phenotypic Screening
Nightingale, L., Tuersley, J., Warchal, S., Cairoli, A., Howes, J., Shand, C., Powell, A., Green, D., Strange, A., Howell, M.
10.1101/2024.04.19.590313 — Posted: 2026-05-22
Discovery of a sulfotyrosine-motif in the human TrkB extracellular domain required for agonist activation
Briggs, D. C., Duffy, R. T., Ateaque, S., Maslen, S., Naharaj, H., Barde, Y.-A., DiStefano, P. S., Lindsay, R. M., Armstrong, P. C., Peach, C. J., McDonald, N. Q.
10.64898/2026.05.19.725324 — Posted: 2026-05-21
A long-chain heparan sulfate capture mechanism directs paracrine GDNF-GFRα1 signalling through RET
Zol-Hanlon, M. I., Rix, B., Bodet-Lefevre, S., Zamora Porras, M., Briggs, D. C., Nans, A., Borg, A. C., Maslen, S. L., Di Maio, A., Feizi, T., Liu, Y., Chopra, P., Boons, G.-J. P., Pavljuk, J., Richter, R. P., Schumann, B., McDonald, N. Q.
10.64898/2026.05.20.726209 — Posted: 2026-05-21
Blocking mechanical airway epithelia damage during asthma progression reverses airway remodelling and hyperresponsiveness
Bagley, D. C., Russell, T., Martinez-Nunez, R. T., Marcotti, S., Rosenblatt, J.
10.1101/2025.11.10.687569 — Posted: 2026-05-17
Structure of the Pre-Initiation Complex Explains CMGE Biogenesis
Pühringer, T., Canal, B., Palm, G., Butryn, A., Couves, E. C., Willhoft, O., Lewis, J. S., Diffley, J. F. X., Costa, A.
10.64898/2026.05.15.725318 — Posted: 2026-05-17
Gene function and expression profiling in yeast spores, killifish diapause embryos, and their post-dormant offspring cells
Hassan, S., Rodriguez-Lopez, M., Townsend, S., Koksal, B., Akkus, S., Ori, A., Cellerino, A., Ralser, M., Bahler, J.
10.64898/2026.05.08.723705 — Posted: 2026-05-17
Mcm10 braces converging replicative helicases to pull apart origin DNA
Palm, G., Butryn, A., Canal, B., Pühringer, T., Gross, M. H., Diffley, J. F. X., Costa, A.
10.64898/2026.05.15.725099 — Posted: 2026-05-16
H3K27M-driven hypertranscription leads to a new targetable dependency in diffuse midline gliomas
PAL, S., Wang, H., Geisberg, J., Mirza, T., Kohli, K., Nazaretian, A., Knowles, T., Graser, C. J., Bootz, K., Wojcikowska, O., Bartynska, M., Boulton, S. J., Majithiya, J. B., Robinson, H., Smith, G., Stiles, C., Chowdhury, D., Agar, N. Y. R., Mueller, S., Michor, F., Haas-Kogan, D.
10.64898/2026.05.12.724628 — Posted: 2026-05-15

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