Channel:  Francis Crick Institute

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Primary sex determination in chickens depends on DMRT1 dosage, but gonadal sex does not determine secondary sexual characteristics in adult birds
Ioannidis, J., Taylor, G., Zhao, D., Liu, L., Idoko-Akoh, A., Gong, D., Lovell-Badge, R., Guioli, S., McGrew, M., Clinton, M.
10.1101/2020.09.18.303040 — Posted: 2020-09-19
The eukaryotic replisome requires an additional helicase to disarm dormant replication origins
Hill, J., Eickhoff, P., Drury, L., Costa, A., Diffley, J.
10.1101/2020.09.17.301366 — Posted: 2020-09-17
Single-molecule measurements reveal that PARP1 condenses DNA by loop formation
Bell, N. A. W., Haynes, P. J., Brunner, K., Maia de Oliveira, T., Flocco, M., Hoogenboom, B. W., Molloy, J. E.
10.1101/2020.09.15.297887 — Posted: 2020-09-15
A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing
Adams, S., Purkiss, A. G., Knowles, P. P., Nans, A., Briggs, D. C., Borg, A., Earl, C. P., Goodman, K. M., Nawrotek, A., Borg, A. J., McIntosh, P. B., Houghton, F. M., Kjaer, S., McDonald, N. Q.
10.1101/2020.09.13.286047 — Posted: 2020-09-13
Telomere-to-telomere assembly of the genome of an individual Oikopleura dioica from Okinawa using Nanopore-based sequencing
Bliznina, A., Masunaga, A., Mansfield, M. J., Tan, Y., Liu, A. W., West, C., Rustagi, T., Chien, H.-C., Kumar, S., Pichon, J., Plessy, C., Luscombe, N. M.
10.1101/2020.09.11.292656 — Posted: 2020-09-12
Acute depletion of METTL3 identifies a role for N6-methyladenosine in alternative intron/exon inclusion in the nascent transcriptome
Wei, G., Almeida, M., Pintacuda, G., Coker, H., Bowness, J. S., Ule, J., Brockdorff, N.
10.1101/2020.09.10.291179 — Posted: 2020-09-11
The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis
Kerloch, T., Farrugia, F., Maitre, M., Terral, G., Koehl, M., Heng, J. I.-T., Blanchard, M., Doat, H., Leste-Lasserre, T., Goron, A., Gonzales, D., Guillemot, F., Abrous, N., Pacary, E.
10.1101/2020.09.10.290866 — Posted: 2020-09-10
Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson's disease.
Virdi, G. S., Choi, M. L., Yao, Z., Evans, J. R., Athauda, D., Melandri, D., Sylantyev, S., Abramov, A. Y., Patani, R., Gandhi, S.
10.1101/2020.09.08.287797 — Posted: 2020-09-08
Generating single-sex litters: development of CRISPR-Cas9 genetic tools to produce all-male offspring
Douglas, C., Maciulyte, V., Zohren, J., Snell, D. M., Ojarikre, O. A., Ellis, P. J., Turner, J. M. A.
10.1101/2020.09.07.285536 — Posted: 2020-09-07
Plasmodium falciparum guanylyl cyclase-alpha and the activity of its appended P4-ATPase domain are essential for cGMP synthesis and blood stage egress
Nofal, S. D., Patel, A., Blackman, M. J., Flueck, C., Baker, D. A.
10.1101/2020.09.07.285734 — Posted: 2020-09-07

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