Channel:  The Howard Hughes Medical Institute (HHMI)

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In-Situ High-Resolution Cryo-EM Reconstructions from CEMOVIS
Elferich, J., Kaminek, M., Kong, L., Odriozola, A., Kukulski, W., Zuber, B., Grigorieff, N.
10.1101/2025.03.29.646093 — Posted: 2025-03-31
Synaptic editing of frontostriatal circuitry prevents excessive grooming in SAPAP3-deficient mice
Walder-Christensen, K. K., Soliman, H. A., Calakos, N., Dzirasa, K.
10.1101/2025.03.27.645613 — Posted: 2025-03-29
Interleukin-1 receptor antagonist is a conserved early factor for exacerbating tuberculosis susceptibility
Lee, O. V., Ji, D. X., Rosa, B. A., Jaye, D. L., Suliman, S., Mitreva, M., Gabay, C., Vance, R. E., Kotov, D. I.
10.1101/2023.10.27.564420 — Posted: 2025-03-29
IL-25-induced memory ILC2s mediate long-term small intestinal adaptation
Cortez, V. S., Viragova, S., Koga, S., Liu, M., O'Leary, C., Ricardo-Gonzalez, R. R., Schroeder, A. W., Kochhar, N., Klein, O., Diamond, M., Liang, H.-E., Locksley, R. M.
10.1101/2025.03.25.645270 — Posted: 2025-03-29
Directed evolution expands CRISPR-Cas12a genome editing capacity
Ma, E., Chen, K., Shi, H., Wasko, K. M., Esain-Garcia, I., Trinidad, M. I., Zhou, K., Ye, J., Doudna, J. A.
10.1101/2025.03.26.645588 — Posted: 2025-03-26
Delphy: scalable, near-real-time Bayesian phylogenetics for outbreaks
Varilly, P., Schifferli, M., Yang, K., Burcham, T., Cronan, P., Glennon, O., Jacks, O., Laning, E., Marrs, L., Oba, K., Yeung, S., Parker, E., Omah, I., Pekar, J. E., Luebbert, L., Andersen, K. G., Park, D. J., Schaffner, S. F., MacInnis, B. L., Happi, C., Lemieux, J. E., Ozonoff, A., Mitzenmacher, M. D., Fry, B., Sabeti, P. C.
10.1101/2025.03.25.645253 — Posted: 2025-03-26
Long-term editing of brain circuits in mice using an engineered electrical synapse
Ransey, E., Thomas, G., Wisdom, E., Almoril-Porras, A., Bowman, R., Adamson, E., Walder-Christensen, K. K., White, J. A., Hughes, D. N., Schwennesen, H., Ferguson, C., Tye, K., Mague, S. D., Niu, L.-G., Wang, Z.-W., Colon-Ramos, D., Hultman, R., Bursac, N., Dzirasa, K.
10.1101/2025.03.25.645291 — Posted: 2025-03-26
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Agarwal, G., Antoszewski, M., Xie, X., Pershad, Y., Arora, U. P., Poon, C.-L., Lyu, P., Lee, A. J., Guo, C.-J., Ye, T., Norford, L. B., Neehus, A.-L., della Volpe, L., Wahlster, L., Ranasinghe, D., Ho, T.-C., Barlowe, T. S., Chow, A., Schurer, A., Taggart, J., Durham, B. H., Abdel-Wahab, O., McGraw, K. L., Allan, J. M., Soldatov, R., Bick, A. G., Kharas, M. G., Sankaran, V. G.
10.1101/2025.03.24.645017 — Posted: 2025-03-26
Addendum to Ancient DNA data from Mengzi Ren, a Late Pleistocene individual from Southeast Asia, cannot be reliably used in population genetic analysis
Tabin, D. R., Patterson, N. J., Mah, M., Reich, D. E.
10.1101/2025.03.24.645126 — Posted: 2025-03-26
Short-term alterations in dietary amino acids override host genetic susceptibility and reveal mechanisms of Salmonella Typhimurium small intestine colonization
Shealy, N., Baltagulov, M., de Brito, C., McGovern, A., Castro, P., Schrimpe-Rutledge, A. C., Malekshahi, C., Condreanu, S. G., Sherrod, S. D., Jana, S., Jones, K., Machado Ribeiro, T. R., McLean, J., Beiting, D. P., Byndloss, M. X.
10.1101/2025.03.25.645332 — Posted: 2025-03-25

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