Channel:  The Howard Hughes Medical Institute (HHMI)

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A reference brain for the clonal raider ant
Frank, D. D., Lopes, L. E., Mohanta, R., Seckler, I., Lacroix, I., Kronauer, D. J. C.
10.1101/2025.10.13.679875 — Posted: 2025-10-14
The mycomembrane proteins PorH and ProtX are inserted at polar growth zones and linked to the cell wall
Hart, E. M., de Bruin, D. A., Marando, V. M., Alemany, M. A., Snow, E. D., Schultz, B. J., Kuru, E., Walker, S., Vettiger, A., Bernhardt, T. G.
10.1101/2025.10.14.682376 — Posted: 2025-10-14
High-Throughput De Novo Protein Design Yields Novel Immunomodulatory Agonists
Abedi, M., Exposit, M., Coventry, B., Mathew, D., Jain, S., Krishnakumar, A., Goreshnik, I., Gray-Gaillard, S., Lunn-Halbert, M., Yu, T.-Y., Glögl, M., Mitchell, U., Keshri, R., Chun, J. H., Ruohola-Baker, H., Wherry, E. J., Baker, D.
10.1101/2025.10.12.681920 — Posted: 2025-10-13
Rapid development and field evaluation of a portable CRISPR-based assay for Mpox during the 2025 Sierra Leone outbreak
Gopal, N., Abay, T., Payne, C., Gomez, M., Fofanah, I. U., Rogers, M. M., Kallon, T. P., Kamara, M. S., Suk, H.-J., Sandi, J. D., Brock-Fisher, T., Stachler, E., Allan-Blitz, L.-T., Roach, D. J., Paye, M. F., Wilkason, C., Grant, D. S., Ozonoff, A., Sabeti, P. C.
10.1101/2025.10.08.25337506 — Posted: 2025-10-13
Direct cell reprogramming by a designed agonist inducing HER2-FGFR proximity
Keshri, R., Exposit, M., Abedi, M., R Hicks, D., Foreman, Z., Phal, A., Lim, Y. C., Barrett, P., Sniezek, C., Lin, J., Schlichthaerle, T., J Robinson, A., Detraux, D., Ching, T. C., Wu, K., Coventry, B., Chang, L., S.T. Smith, A., L Mack, D., K Schweppe, D., Martin, B. E., Hristova, K., Mathieu, J., Baker, D., Ruohola-Baker, H.
10.1101/2025.10.12.681903 — Posted: 2025-10-13
Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins
Rehfeld, F., Lundstrom, C., Zhang, H., Mendell, J. T.
10.1101/2025.10.13.682107 — Posted: 2025-10-13
Single-sequence deep learning delivers crystal-quality models of covalent K-Ras G12 hotspot complexes
Jung, S., Zheng, Q., Shokat, K.
10.1101/2025.09.16.676163 — Posted: 2025-10-13
Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling
Exposit, M., Abedi, M., Krishnakumar, A., Jain, S., Yu, T.-Y., Hercus, T. R., Mathew, D., Gray-Gaillard, S., Chen, Z., Grubbe, W. S., Favor, A., Kan, W. L., Schlichthaerle, T., Chen, W., Parker, M. W., Mendoza, J. L., Lopez, A. F., Wherry, E. J., Baker, D.
10.1101/2025.10.12.681819 — Posted: 2025-10-13
Multiplex design and discovery of proximity handles for programmable proteome editing
Suiter, C. C., Ahn, G., Chiu, M., Fu, Y., Sadre, S., Simon, J. J., Lee, D. S., Fowler, D. M., Maly, D. J., Baker, D., Shendure, J.
10.1101/2025.10.13.681693 — Posted: 2025-10-13
Ultra-mild bisulfite outperforms existing methods for 5-methylcytosine detection with low input DNA
He, C., Dai, Q., Baldwin, T., Lyu, R., Daniels, B., Ye, C., Cao, C., Zhu, C., Fan, D., Lin, L., Liu, Y., Wang, Y.
10.1101/2025.10.09.681456 — Posted: 2025-10-11

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