Channel:  The Howard Hughes Medical Institute (HHMI)

1,975 Articles

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T cell engagers control solid tumors through clonal replacement and IL2-driven effector differentiation of CD8 T-cells
Obenaus, M., Poupault, C. L., McGinnis, C. S., Prange, C., Jiang, H., Su, L. L., Chen, X., Miao, Z., Muldoon, J. J., Yao, W., Waghray, D., Sun, Q., Eyquem, J., Hernandez-Lopez, R. A., Satpathy, A. T., Sage, J., Garcia, K. C.
10.64898/2025.12.04.692214 — Posted: 2026-01-27
Defective splicing of Y-chromosome-linked gigantic genes contributes to hybrid male sterility in Drosophila
Fontan, A., Lannes, R., Fingerhut, J., Flynn, J., Yamashita, Y. M.
10.1101/2025.05.22.655455 — Posted: 2026-01-26
A single-cell atlas of intestinal immune cells across the day-night cycle reveals dynamic populations
Maples, R. W., Quinn, G., Srinivasan, T., Dende, C., Hooper, L. V., Pfeiffer, J. K.
10.64898/2026.01.24.701519 — Posted: 2026-01-26
Comparative Proteomic Profiling of Receptor Kinase Signaling Reveals Key Trafficking Components Enforcing Plant Stomatal Development
Bai, P., Vu, M. H., Komatsu, C., Papoulas, O., Ebine, K., Nozawa, A., Sawasaki, T., Ueda, T., Marcotte, E. M., Torii, K. U.
10.1101/2025.07.20.665823 — Posted: 2026-01-26
Kinetochore clustering is mediated by Mps1 phosphorylation of conserved MELT motifs in Stu1
Mallet, D. R., Jiang, M., Minnuto, G. M., Biggins, S.
10.64898/2026.01.23.701336 — Posted: 2026-01-25
TAK1 integrates the NLRP1 inflammasome into the innate immune response to double-stranded RNA
Corley, M. R., Hyodo, A., Toyoda, H. C., Yonemitsu, M. A., Chantharath, A., Hyde, J. L., Mitchell, P. S.
10.64898/2026.01.23.701331 — Posted: 2026-01-25
Long-term post-ovariectomy mouse model recapitulates hypothalamic transcriptomic changes observed during the menopausal transition in women
Bloom, J. C. B., Torres, E., Pereira, S. A., Arvizu-Sanchez, L., Fontes, A. N., Joffe, H., Page, D. C., Navarro, V. M.
10.1101/2024.10.05.616758 — Posted: 2026-01-24
Nuclear envelope budding is a non-canonical mechanism to export large transcripts in muscle cells
Zaganelli, S., Meehl, J., Abrisch, R. G., Voeltz, G. K.
10.1101/2025.04.18.649598 — Posted: 2026-01-24
Engaging Unstabilized Alkyl Radicals with Pyridoxal Radical Biocatalysis: Enantiodivergent Synthesis of Aliphatic Non-Canonical Amino Acids
Cheng, L., Chen, J., Bo, Z., Zhang, X., Liu, P., Yang, Y.
10.64898/2026.01.21.700944 — Posted: 2026-01-23
Efficient transgene-free multiplexed genome editing via viral delivery of an engineered TnpB.
Weiss, T., Kamalu, M., Shi, H., Wirnowski, G., Ingelsson, A., Amerasekera, J., Vohra, K., Trinidad, M. I., Li, Z., Freitas, E., Steinmetz, N., Ambrose, C., Chen, K., Doudna, J. A., Jacobsen, S. E.
10.64898/2026.01.23.700382 — Posted: 2026-01-23

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