Channel:  The Howard Hughes Medical Institute (HHMI)

2,311 Articles

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Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9
Eggers, A. R., Chen, K., Soczek, K. M., Tuck, O. T., Doherty, E. E., Thornton, B. W., Xu, B., Trinidad, M. I., Doudna, J. A.
10.1101/2023.12.14.571777 — Posted: 2023-12-15
Substrate-interacting pore loops of two ATPase subunits determine the degradation efficiency of the 26S proteasome
Martin, A., Lopez-Alfonzo, E. M., Saurabh, A., Zarafshan, S., Presse, S.
10.1101/2023.12.14.571752 — Posted: 2023-12-15
Connectivity underlying motor cortex activity during naturalistic goal-directed behavior
Finkelstein, A., Daie, K., Rozsa, M., Darshan, R., Svoboda, K.
10.1101/2023.11.25.568673 — Posted: 2023-12-15
A translation-independent directed evolution strategy to engineer aminoacyl-tRNA synthetases
Soni, C., Prywes, N., Hall, M., Savage, D. F., Schepartz, A., Chatterjee, A.
10.1101/2023.12.13.571473 — Posted: 2023-12-14
Rapid, concerted switching of the neural code in inferotemporal cortex
Shi, Y., Bi, D., Hesse, J. K., Lanfranchi, F. F., Chen, S., Tsao, D. Y.
10.1101/2023.12.06.570341 — Posted: 2023-12-13
MBD2 couples DNA methylation to Transposable Elements silencing during male gametogenesis.
Wang, S., Wang, M., Ichino, L., Boone, B. A., Zhong, Z., Papareddy, R. K., Lin, E. K., Yun, J., Feng, S., Jacobsen, S. E.
10.1101/2023.12.12.571353 — Posted: 2023-12-13
The juxtamembrane linker of synaptotagmin 1 regulates Ca2+ binding via liquid-liquid phase separation
Mehta, N., Mondal, S., Watson, E. T., Cui, Q., Chapman, E. R.
10.1101/2023.08.11.551903 — Posted: 2023-12-13
An interactive web application for exploring human plasma and fibroblast metabolomics data from patients with inborn errors of metabolism
Cai, L., Hieu, V., Gu, W., Chen, H., Franklin, J., Abou Haidar, L., Wu, Z., Pan, C., Cai, F., Nguyen, P., Ko, B., Yang, C., Zacharias, L. G., Sudderth, J., Montgomery, S., Uhles, C., Fisher, H., Hudnall, J., Hornbuckle, C., Quinn, C., Michel, D., Umana, L., Scheuerle, A., McNutt, M., Gotway, G., Afroze, B., Ni, M., DeBerardinis, R. J.
10.1101/2023.12.11.571124 — Posted: 2023-12-12
Single molecule studies of the native hair cell mechanosensory transduction complex
Clark, S., Mitra, J., Elferich, J., Goehring, A., Ge, J., Ha, T., Gouaux, E.
10.1101/2023.12.11.571162 — Posted: 2023-12-12
RluA is the major mRNA pseudouridine synthase in Escherichia coli
Schaening Burgos, C., Li, G.-W., Gilbert, W. V.
10.1101/2023.12.08.570740 — Posted: 2023-12-12

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