Channel:  The Howard Hughes Medical Institute (HHMI)

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PEARL-catalyzed peptide bond formation after chain reversal during the biosynthesis of non-ribosomal peptides
Yu, Y., van der Donk, W.
10.1101/2023.12.23.573212 — Posted: 2023-12-23
Atomic context-conditioned protein sequence design using LigandMPNN
Dauparas, J., Lee, G. R., Pecoraro, R., An, L., Anishchenko, I., Glasscock, C., Baker, D.
10.1101/2023.12.22.573103 — Posted: 2023-12-23
Genome evolution is surprisingly predictable after initial hybridization
Langdon, Q. K., Groh, J. S., Aguillon, S., Powell, D. L., Gunn, T. R., Payne, C. Y., Baczenas, J. J., Donny, A., Dodge, T. O., Du, K., Schartl, M., Rios-Cardenas, O., Gutierrez-Rodriguez, C., Morris, M., Schumer, M.
10.1101/2023.12.21.572897 — Posted: 2023-12-23
Carcinogenesis is associated with sex-biased tissue environments and imbalances between estrogen receptor alpha and thyroid hormone receptors
Zhang, F., Deng, M.
10.1101/2023.05.20.541565 — Posted: 2023-12-21
Identification of a short, single site matriglycan that maintains neuromuscular function in the mouse
Yang, T., Chandel, I., Gonzales, M., Okuma, H., Prouty, S. J., Zarei, S., Joseph, S., Garringer, K. W., Ocampo Landa, S., Yonekawa, T., Walimbe, A. S., Venzke, D. P., Anderson, M. E., Hord, J. M., Campbell, K. P.
10.1101/2023.12.20.572361 — Posted: 2023-12-21
De novo design of diverse small molecule binders and sensors using Shape Complementary Pseudocycles
An, L., Said, M., Tran, L., Majumder, S., Goreshnik, I., Lee, G. R., Juergens, D., Dauparas, J., Anishchenko, I., Coventry, B., Bera, A. K., Kang, A., Levine, P. M., Alvarez, V., Pillai, A., Norn, C., Feldman, D., Zorine, D., Hicks, D. R., Li, X., Sanchez, M. G., Vafeados, D. K., Salveson, P. J., Vorobieva, A. A., Baker, D.
10.1101/2023.12.20.572602 — Posted: 2023-12-21
Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation
Li, H., Ji, Z., Paulo, J. A., Gygi, S. P., Rapoport, T. A.
10.1101/2023.12.20.572403 — Posted: 2023-12-20
Extreme restructuring of cis-regulatory regions controlling a deeply conserved plant stem cell regulator
Ciren, D., Zebell, S., Lippman, Z.
10.1101/2023.12.20.572550 — Posted: 2023-12-20
A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines
Lee, J., Stewart, C., Schaefer, A., Leaf, E. M., Park, Y.-J., Asarnow, D., Powers, J. M., Treichel, C., Corti, D., Baric, R., King, N. P., Veesler, D.
10.1101/2023.12.12.571160 — Posted: 2023-12-20
The membrane curvature inducing REEP1 proteins generate a novel ER-derived vesicular compartment
Shibata, Y., Mazur, E. E., Pan, B., Hernandez, S. V., Zhang, J., Rapoport, T. A.
10.1101/2023.12.19.572386 — Posted: 2023-12-19

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