Channel:  Arc Institute

42 Articles

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Efficient generation of epitope-targeted de novo antibodies with Germinal
Mille-Fragoso, L. S., Driscoll, C. L., Wang, J. N., Dai, H., Widatalla, T. M., Zhang, J. L., Zhang, X., Rao, B., Feng, L., Hie, B. L., Gao, X. J.
10.1101/2025.09.19.677421 — Posted: 2026-04-15
ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance
Wang, S., Guo, Y., An, W., Lee, M., Li, Y., Sudaryo, V., Grenot, G., Skariah, G., Reghupaty, S. C., Young, S., Bai, X., Svensson, K. J., Li, L.
10.64898/2026.04.12.718013 — Posted: 2026-04-14
Systemic hypoxia suppresses solid tumor growth
Midha, A. D., Chew, B. T. L., Choi, B. M. H., Suh, J. M., Carpenter, C., Baik, A. H., Joshi, T., Blume, S. Y., Haribowo, A. G., Ruivo, P., Flanigan, W. R., Garg, A., Zhang, D. D., Subramanyam, V., Shuere, R., Seo, Y., VanBrocklin, H., Goodarzi, H., Jain, I. H.
10.64898/2026.02.09.704975 — Posted: 2026-02-10
Structure-guided design of a targeted autoantibody degrader for neurologic disease
Zimanyi, M., Dayao, M., Asencor, A. I., Kondapavulur, S., Asaki, J., McCutcheon, K., Dabaco, C., Bodansky, A., Craik, C., Pleasure, S., DeRisi, J. L., Cheng, Y., Wilson, M., Pluvinage, J. V.
10.64898/2026.02.01.703132 — Posted: 2026-02-03
Genome-wide CRISPRi screen identifies basigin loss as protective in cardiac hypoxia
Flanigan, W. R., Midha, A. D., Blume, S. Y., Marti-Mateos, Y., Costa, M. W., Huang, Y., Baik, A. H., Huynh, H., Susarla, G., Bennett, N. K., Nowak, R. A., Srivastava, D., Nakamura, K., Jain, I. H.
10.64898/2026.01.26.701810 — Posted: 2026-01-27
cyto: ultra high-throughput processing of 10x-flex single cell sequencing
Teyssier, N., Dobin, A.
10.64898/2026.01.21.700936 — Posted: 2026-01-22
scBaseCount: an AI agent-curated, uniformly processed, and autonomously updated single cell data repository
Youngblut, N. D., Carpenter, C., Nayebnazar, A., Adduri, A., Shah, R., Ricci-Tam, C., Prashar, J., Ilango, R., Teyssier, N., Konermann, S., Hsu, P., Dobin, A., Burke, D. P., Goodarzi, H., Roohani, Y. H.
10.1101/2025.02.27.640494 — Posted: 2025-11-02
BINSEQ: A Family of High-Performance Binary Formats for Nucleotide Sequences
Teyssier, N., Dobin, A.
10.1101/2025.04.08.647863 — Posted: 2025-10-29
Generative design of novel bacteriophages with genome language models
King, S. H., Driscoll, C. L., Li, D. B., Guo, D., Merchant, A. T., Brixi, G., Wilkinson, M. E., Hie, B. L.
10.1101/2025.09.12.675911 — Posted: 2025-09-17
Predicting cellular responses to perturbation across diverse contexts with STATE
Adduri, A. K., Gautam, D., Bevilacqua, B., Imran, A., Shah, R., Naghipourfar, M., Teyssier, N., Ilango, R., Nagaraj, S., Ricci-Tam, C., Carpenter, C., Subramanyam, V., Winters, A., Dong, M., Tirukkovalur, S., Sullivan, J., Plosky, B. S., Eraslan, B., Youngblut, N. D., Leskovec, J., Gilbert, L. A., Konermann, S., Hsu, P. D., Dobin, A., Burke, D. P., Goodarzi, H., Roohani, Y. H.
10.1101/2025.06.26.661135 — Posted: 2025-07-10

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