Channel:  Arc Institute

42 Articles

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A generative framework for enhanced cell-type specificity in rationally designed mRNAs
Khoroshkin, M. S., Zinkevich, A., Aristova, E., Yousefi, H., Lee, S. B., Mittmann, T., Manegold, K., Penzar, D., Raleigh, D. R., Kulakovskiy, I. V., Goodarzi, H.
10.1101/2024.12.31.630783 — Posted: 2024-12-31
Semantic mining of functional de novo genes from a genomic language model
Merchant, A. T., King, S. H., Nguyen, E., Hie, B. L.
10.1101/2024.12.17.628962 — Posted: 2024-12-18
Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations
Yu, J. X., Suh, J. M., Popova, K. D., Garcia, K., Joshi, T., Culbertson, B., Spinelli, J. B., Subramanyam, V., Lou, K., Shokat, K. M., Weissman, J., Goodarzi, H.
10.1101/2024.12.13.628239 — Posted: 2024-12-16
A combinatorial domain screening platform reveals epigenetic effector interactions for transcriptional perturbation
Moon, H. C., Herschl, M. H., Pawluk, A., Konermann, S., Hsu, P. D.
10.1101/2024.10.28.620683 — Posted: 2024-11-05
Site-specific DNA insertion into the human genome with engineered recombinases
Fanton, A., Bartie, L. J., Martins, J. Q., Tran, V. Q., Goudy, L., Durrant, M. G., Wei, J., Pawluk, A., Konermann, S., Marson, A., Gilbert, L. A., Hsu, P. D.
10.1101/2024.11.01.621560 — Posted: 2024-11-03
Combinatorial effector targeting (COMET) for transcriptional modulation and locus-specific biochemistry
Wilson, C. M., Pommier, G. C., Richman, D. D., Sambold, N., Hussmann, J. A., Weissman, J. S., Gilbert, L. A.
10.1101/2024.10.28.620517 — Posted: 2024-10-28
A Suite of Foundation Models Captures the Contextual Interplay Between Codons
Naghipourfar, M., Chen, S., Howard, M., Macdonald, C., Saberi, A., Hagen, T., Mofrad, M., Coyote-Maestas, W., Goodarzi, H.
10.1101/2024.10.10.617568 — Posted: 2024-10-13
Toxicity of extracellular cGAMP and its analogs to T cells is due to SLC7A1-mediated import
Sudaryo, V., R. Carvalho, D., Lee, J. M., Carozza, J. A., Cao, X., Cordova, A. F., Li, L.
10.1101/2024.09.21.614248 — Posted: 2024-09-24
Human STING oligomer function is governed by palmitoylation of an evolutionarily conserved cysteine
Chan, R. J. M., Cao, X., Ergun, S. L., Njomen, E., Lynch, S. R., Ritchie, C., Cravatt, B. F., Li, L.
10.1101/2023.08.11.553045 — Posted: 2024-05-13
Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers
Wang, J., Suh, J. M., Woo, B. J., Navickas, A., Garcia, K., Yin, K., Fish, L., Cavazos, T., Hanisch, B., Markett, D., Yu, S., Hirst, G., Brown-Swigart, L., Esserman, L. J., van 't Veer, L. J., Goodarzi, H.
10.1101/2024.03.19.585748 — Posted: 2024-03-21

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