Channel:  Arc Institute

33 Articles

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Semantic mining of functional de novo genes from a genomic language model
Merchant, A. T., King, S. H., Nguyen, E., Hie, B. L.
10.1101/2024.12.17.628962 — Posted: 2024-12-18
Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations
Yu, J. X., Suh, J. M., Popova, K. D., Garcia, K., Joshi, T., Culbertson, B., Spinelli, J. B., Subramanyam, V., Lou, K., Shokat, K. M., Weissman, J., Goodarzi, H.
10.1101/2024.12.13.628239 — Posted: 2024-12-16
A combinatorial domain screening platform reveals epigenetic effector interactions for transcriptional perturbation
Moon, H. C., Herschl, M. H., Pawluk, A., Konermann, S., Hsu, P. D.
10.1101/2024.10.28.620683 — Posted: 2024-11-05
Site-specific DNA insertion into the human genome with engineered recombinases
Fanton, A., Bartie, L. J., Martins, J. Q., Tran, V. Q., Goudy, L., Durrant, M. G., Wei, J., Pawluk, A., Konermann, S., Marson, A., Gilbert, L. A., Hsu, P. D.
10.1101/2024.11.01.621560 — Posted: 2024-11-03
Combinatorial effector targeting (COMET) for transcriptional modulation and locus-specific biochemistry
Wilson, C. M., Pommier, G. C., Richman, D. D., Sambold, N., Hussmann, J. A., Weissman, J. S., Gilbert, L. A.
10.1101/2024.10.28.620517 — Posted: 2024-10-28
A long context RNA foundation model for predicting transcriptome architecture
Saberi, A., Choi, B., Wang, S., Hernandez-Corchado, A., Naghipourfar, M., Namini, A., Ramani, V., Emad, A., Najafabadi, H. S., Goodarzi, H.
10.1101/2024.08.26.609813 — Posted: 2024-10-21
A Suite of Foundation Models Captures the Contextual Interplay Between Codons
Naghipourfar, M., Chen, S., Howard, M., Macdonald, C., Saberi, A., Hagen, T., Mofrad, M., Coyote-Maestas, W., Goodarzi, H.
10.1101/2024.10.10.617568 — Posted: 2024-10-13
Toxicity of extracellular cGAMP and its analogs to T cells is due to SLC7A1-mediated import
Sudaryo, V., R. Carvalho, D., Lee, J. M., Carozza, J. A., Cao, X., Cordova, A. F., Li, L.
10.1101/2024.09.21.614248 — Posted: 2024-09-24
Accurate isoform quantification by joint short- and long-read RNA-sequencing
Apostolides, M., Choi, B., Navickas, A., Saberi, A., Soto, L. M., Goodarzi, H., Najafabadi, H. S.
10.1101/2024.07.11.603067 — Posted: 2024-07-13
Human STING oligomer function is governed by palmitoylation of an evolutionarily conserved cysteine
Chan, R. J. M., Cao, X., Ergun, S. L., Njomen, E., Lynch, S. R., Ritchie, C., Cravatt, B. F., Li, L.
10.1101/2023.08.11.553045 — Posted: 2024-05-13

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