Channel:  Aligning Science Across Parkinson's (ASAP)

392 Articles

Structural and functional landscape of α-synuclein fibril conformations amplified from cerebrospinal fluid
Sokratian, A., Zhou, Y., Xu, E., Viverette, E., Dillard, L., Yuan, Y., Li, J., Matarangas, A., Bouvette, J., Borgnia, M. J., Bartesaghi, A., West, A.
10.1101/2022.07.13.499896 — Posted: 2022-07-13
Mitoguardin-2 is a lipid transporter and its lipid transfer ability is required for function
Hong, Z., Adlakha, J., Guinn, E., Giska, F., Gupta, K., Melia, T., Reinisch, K. M.
10.1101/2022.07.08.499339 — Posted: 2022-07-09
DOPA pheomelanin is increased in nigral neuromelanin of Parkinson's disease and it exacerbates alpha-synuclein neurotoxicity
Cai, W., Wakamatsu, K., Zucca, F., Yang, K., Mohamadzadehhonarvar, N., Srivastava, P., Holly, G., Casella, L., Ito, S., Zecca, L., Chen, X.
10.1101/2022.06.30.22277063 — Posted: 2022-07-03
A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice
Abdel-Haq, R., Schlachetzki, J. C. M., Boktor, J. C., Cantu-Jungles, T. M., Thron, T., Zhang, M., Bostick, J. W., Khazaei, T., Chilakala, S., Morais, L. H., Humphrey, G., Keshavarzian, A., Katz, J. E., Thomson, M., Knight, R., Gradinaru, V., Hamaker, B. R., Glass, C. K., Mazmanian, S. K.
10.1101/2022.06.27.497828 — Posted: 2022-06-30
Synaptic Location Is a Determinant of the Detrimental Effects of alpha-Synuclein Pathology to Glutamatergic Transmission in the Basolateral Amygdala
Chen, L., Nagaraja, C., Daniels, S., Fisk, Z. A., Dvorak, R., Meyerdirk, L., Steiner, J. A., Galvis, M. L. E., Henderson, M., Rousseaux, M., Brundin, P., Chu, H.-y.
10.1101/2022.02.20.481207 — Posted: 2022-06-30
Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling
Harding, O., Holzbaur, E. L. F.
10.1101/2022.06.21.496850 — Posted: 2022-06-22
Dopaminergic axons track somatic signaling in behaving mice
Azcorra, M., Gaertner, Z., Davidson, C., Ramakrishnan, C., Fenno, L., Kim, Y. S., Deisseroth, K., Awatramani, R., Dombeck, D. A.
10.1101/2022.06.20.496872 — Posted: 2022-06-22
Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms
Wallen, Z. D., Demirkan, A., Twa, G., Cohen, G., Dean, M. N., Standaert, D. G., Sampson, T., Payami, H.
10.1101/2022.06.08.495316 — Posted: 2022-06-12
Structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Choi, M. L., Chappard, A., Singh, B. P., Maclachlan, C., Rodrigues, M., Fedotova, E., Berezhnov, A., De, S., Peddie, C., Athauda, D., Virdi, G. S., Zhang, W., Evans, J. R., Wernick, A., Zanjani, Z., Angelova, P. R., Esteras, N., Andrey, A., Morris, K., Jeacock, K., Tosatto, L., Little, D., Gissen, P., Collinson, L., Clarke, D. J., Kunath, T., Klenerman, D., Abramov, A. Y., Horrocks, M. H., Gandhi, S.
10.1101/2022.06.07.494932 — Posted: 2022-06-09
The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines.
Smith, L. J., Bolsinger, M. M., Chau, K.-Y., Gegg, M. E., Schapira, A. H. V.
10.1101/2022.06.01.494130 — Posted: 2022-06-01

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