COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,722 Articles (22,913 medRxiv, 8,809 bioRxiv)

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Structural Divergence without Functional Impact: Comparative Characterization of SARS-CoV-2 3CL-Mpro Variants Using Cleavage Site Substrates
Saha, D., Dakhili, S. Y. T., Mar, E., Chen, Y. S., VanPetegem, F., Bromme, D.
10.64898/2025.12.23.696280 — Posted: 2025-12-26
Change in Fatigue over 15 months in people the Post-Covid Syndrome
Mayo, N., Hum, S., Nadeau, L., Brouillette, M.-J., Fellows, L. K.
10.64898/2025.12.20.25342742 — Posted: 2025-12-22
Identification of allo- or orthosteric VHH/single-domain antibodies that enhance or block pathogen binding to Siglec-1 on dendritic cells
Brink, H. J., Affandi, A. J., Man, S., Dekker, N. C. C. T., Grosse Wichtrup, E. A., Bouma, R. G., Seyed Toutounchi, N., Konijn, V. A. L., Stolwijk, J. G. C., van Hamme, J. L., Olesek, K., Heijnen, D. A. M., Fish, A., Moutsiopoulou, A., Celie, P., Dekkers, G., Heukers, R., Mastrobattista, E., Smit, M. J., van Kooyk, Y., Heikema, A. P., Kootstra, N. A., Geijtenbeek, T. B. H., den Haan, J. M. M.
10.64898/2025.12.19.695420 — Posted: 2025-12-22
AI Identifies Broadly Neutralizing Antibodies from an IGHV1-69 Public Antibody Class Exerting Continued Selection Over SARS-CoV-2
Niu, C., Huang, X., Yan, Q., Liu, B., Gao, X., Song, Y., Wang, J., Wang, L., Li, Z., Zheng, H., He, P., Huang, X., Yuan, H., Zou, B., Yang, Y., Wu, F., Yao, Y., Habib, G., Chen, X., Chen, L., He, J., Yao, J., Zhao, J., Xiong, X.
10.64898/2025.12.19.695307 — Posted: 2025-12-22
Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer's disease neuropathology yet induces wide-spread changes in gene expression across diverse cell types
Furman, S., Zayou, L., Tsourmas, K. I. I., Javonillo, D. I., Olivarria, G. M., Cheng, Y., Pachow, C., Fernandez, K., Le, L., Edwards, R. A., Nicholas, D., Sanchez, G. P., Baric, R. S., Green, K. N., Lane, T. E.
10.64898/2025.12.19.695600 — Posted: 2025-12-22
Including gender-specific features in epidemic modeling: the case of the second wave of COVID-19 in Italy
De Gaetano, A., Coletti, P., Perra, N., Barrat, A., Paolotti, D.
10.64898/2025.12.19.25342675 — Posted: 2025-12-21
Evidence of Accumulating Neurophysiologic Dysfunction in Persistent Post-COVID Fatigue
Germann, M., Maffitt, N. J., Burton, O. A., Ashhad, A., Baker, A. M. E., Zaaimi, B., Ng, W.-F., Soteropoulos, D. S., Baker, S. N., Baker, M. R.
10.64898/2025.12.19.25342669 — Posted: 2025-12-21
Identification and genomic characterisation of BA.3.2: a highly divergent BA.3-related SARS-CoV-2 lineage from southern Africa
Dor, G., Kekana, D., Hisner, R., Martin, D. P., Korber, B., Gueli, F., Ernst, T., Levy, A., Speers, D., Turville, S., Sintchenko, V., Basile, K., Sullivan, G., Rockett, R., Kok, J., Lessels, R., Wolter, N., von Gottberg, A., Tegally, H., de Oliveira, T.
10.64898/2025.12.19.25342658 — Posted: 2025-12-20
An Oral Combination therapy against SARS-CoV-2 based on Synergistic Action of Auranofin and Remdesivir.
Khatun, O., Narayan, R., Nagaraj, S. K., Shiraz, R., Kaliappan, A., Kaur, S., Singh, A., Narayanan, S., Shandil, R., Tomar, S., Tripathi, S.
10.64898/2025.12.19.695342 — Posted: 2025-12-19
The pharmacokinetics, bio-distribution and therapeutic efficacy of a trimeric nanobody against SARS-CoV-2 in the Syrian golden hamster COVID-19 model
Sharma, P., Mega, D., Kirby, A., Buckle, I., Kipar, A., Clark, J., Bentley, E., Eyssen, L., Kijak, E., Herriott, J., Sharp, J., Carroll, M. W., Owens, R., Stewart, J. P.
10.64898/2025.12.17.694727 — Posted: 2025-12-19

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).