Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
https://biorxiv.org
This feed contains articles for Collection "COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv"
bioRxivbioRxiv/medRxiv
https://biorxiv.org
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Targeted metagenomic recovery of coronaviruses from wildlife samples
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https://www.biorxiv.org/content/10.64898/2026.05.05.722935v1?rss=1"
Johnston, C. M.Gunalan, V.Baagoe, H. J.Elmeros, M.Fjederholt, E. T.Quaade, M. L.Hansen, M. J. S.Lohse, L.Rasmussen, T. B.2026-05-05doi:10.64898/2026.05.05.722935Cold Spring Harbor Laboratory Press2026-05-05
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Condensate-Like Organization in Respiratory Aerosols Modulates the Dynamics of an Airborne Virus
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https://www.biorxiv.org/content/10.64898/2026.04.30.721971v1?rss=1"
Wauer, N.Calvo-Tusell, C.Dommer, A.Casalino, L.Kearns, F.Caparotta, M.Rosenfeld, M.Morris, C.Amaro, R. E.2026-05-04doi:10.64898/2026.04.30.721971Cold Spring Harbor Laboratory Press2026-05-04
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Connecting Cryo-EM and Crystallographic Views of RNA Folding through Ionic Conditions and Structural Flexibility
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https://www.biorxiv.org/content/10.64898/2026.05.02.722415v1?rss=1"
Mainan, A.Roy, S.Kirmizialtin, S.2026-05-04doi:10.64898/2026.05.02.722415Cold Spring Harbor Laboratory Press2026-05-04
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SARS-CoV-2 (E)-protein induces rapid TLR2-mediated T cell activation in mouse lungs revealed by intravital lung microscopy
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https://www.biorxiv.org/content/10.64898/2026.05.03.722459v1?rss=1"
Shaalan, Y.Kuruppu, N.Orinska, Z.Li, C.Koops, F.Wasnick, R.Noessner, E.Stoeger, T.Meiners, S.Rehberg, M.2026-05-04doi:10.64898/2026.05.03.722459Cold Spring Harbor Laboratory Press2026-05-04
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Single-cell atlas of transcript usage remodelling in antiviral immune responses across human populations
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https://www.biorxiv.org/content/10.64898/2026.04.30.721889v1?rss=1"
Chazarra-Gil, R.Ripoll-Cladellas, A. R.-C.Sopena-Rios, M.Mestres-Pascual, I.Calvo, M.Reverter, F.Garrido-Martin, D.Mele, M.2026-05-04doi:10.64898/2026.04.30.721889Cold Spring Harbor Laboratory Press2026-05-04
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Early functional maturation of anti-Spike antibodies predicts SARS-CoV-2 RNA clearance in mild infection
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https://www.medrxiv.org/content/10.64898/2026.04.30.26352163v1?rss=1"
Rodrigues, D.Araujo, B.Pestana, J.da Costa, L.Andrade, M.de Freitas, L.Nery, B.Bozza, V.Conde, L.Raposo, L.Gama, A.Mendes, V.Cobos, E.Higa, L.Galliez, R.Tanuri, A.Ferreira, O.Castilho, L.Castineiras, T.Echevarria, J.Bozza, M.Vale, A. M.2026-05-03doi:10.64898/2026.04.30.26352163Cold Spring Harbor Laboratory Press2026-05-0321 days) groups. Non-persistent individuals exhibited accelerated seroconversion to Spike and receptor-binding domain (RBD) antigens during the first 11 days after symptom onset. Early antibody responses were characterized by higher functional activity, including significantly greater neutralizing activity against the ancestral strain. In contrast, persistent individuals displayed delayed seroconversion, prolonged IgM responses, and weaker coordination among IgG subclasses, with less synchronized subclass responses, during early infection. Importantly, total immunoglobulin levels did not distinguish the groups. Cross-variant antibody recognition during acute infection was limited and largely strain-focused in both groups. During convalescence, durable anti-Spike IgG responses were maintained independently of persistence status, without significant differences in cross-variant breadth. Vaccination robustly amplified antibody titers, enhanced variant recognition, and sustained high-affinity responses in both groups. Together, our findings demonstrate that the timing and functional quality of early humoral maturation, reflected by neutralizing antibody activity, rather than antibody magnitude or breadth, are key determinants of SARS-CoV-2 RNA clearance in mild infection. These results highlight the importance of early neutralizing antibody generation in shaping acute viral control and the long-term immune architecture.
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Modeling healthy proteomic profiles for anomaly detection using subspace learning based one-class classification
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https://www.biorxiv.org/content/10.64898/2026.04.30.722013v1?rss=1"
Sohrab, F.Kumar, A.Ahola, V.Magis, A.Hautamaki, V.Heinaniemi, M.Huang, S.2026-05-01doi:10.64898/2026.04.30.722013Cold Spring Harbor Laboratory Press2026-05-01
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Global burden of foreign bodies and impact of COVID-19 pandemic
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https://www.medrxiv.org/content/10.64898/2026.04.29.26352072v1?rss=1"
Simayi, F.2026-04-30doi:10.64898/2026.04.29.26352072Cold Spring Harbor Laboratory Press2026-04-30
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Proof-of-concept of targeted degradation of p38α/β MAPK host-kinase as a potent inhibitor of coronaviruses.
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https://www.biorxiv.org/content/10.64898/2026.04.29.721712v1?rss=1"
Cooper, G.Snape, T. J.Shivkumar, M.2026-04-30doi:10.64898/2026.04.29.721712Cold Spring Harbor Laboratory Press2026-04-30
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Changing COVID-19 vaccine eligibility could reshape disease burden for all
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https://www.medrxiv.org/content/10.64898/2026.04.27.26351870v1?rss=1"
Larsen, S. L.Martinez, P. P.Mahmud, A.2026-04-29doi:10.64898/2026.04.27.26351870Cold Spring Harbor Laboratory Press2026-04-29
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Detection and characterization of single SARS-CoV-2 viral particles by flow virometry
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https://www.medrxiv.org/content/10.64898/2026.04.28.26351941v1?rss=1"
Jungbauer-Groznica, M.Commere, P.-H.Cottignies-Calamarte, A.De Cruz, A.Fantin, A.Planchais, C.Guivel-Benhassine, F.Staropoli, I.Schmutz, S.Novault, S.Veyer, D.Pere, H.Mouquet, H.Schwartz, O.Bruel, T.2026-04-29doi:10.64898/2026.04.28.26351941Cold Spring Harbor Laboratory Press2026-04-29
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COVID-19 onset, stay-at-home orders, and racialized inequities in homicide mortality across the US
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https://www.medrxiv.org/content/10.64898/2026.04.28.26351994v1?rss=1"
Tanveer, M.Santaularia Gomez, N. J.Vinita Fitch, K.Holmes, M.Moracco, K. E.Dolan, M.Fulcher, N.Ranapurwala, S. I.2026-04-29doi:10.64898/2026.04.28.26351994Cold Spring Harbor Laboratory Press2026-04-29
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Naturally occurring ACE2 stalk variants are differentially released from the cell.
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https://www.biorxiv.org/content/10.64898/2026.04.27.721131v1?rss=1"
Wiersch, F.Lux, C.Vanderliek-Kox, J.Schun, K.Ludwig, A.Dusterhoft, S.2026-04-29doi:10.64898/2026.04.27.721131Cold Spring Harbor Laboratory Press2026-04-29
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T-cell repertoire response in individuals with post-acute sequelae of COVID-19
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https://www.biorxiv.org/content/10.64898/2026.04.27.721205v1?rss=1"
Montague, Z.Grover, R. M.Baumgartner, A.Trofimov, A.Hadlock, J.Nourmohammad, A.2026-04-29doi:10.64898/2026.04.27.721205Cold Spring Harbor Laboratory Press2026-04-29
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A Deterministic-Stochastic Model for COVID-19 and Malaria Co-Infection with Malaria-Acquired Partial Immunity
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https://www.medrxiv.org/content/10.64898/2026.04.27.26351858v1?rss=1"
Idowu, K. O.Lin, G.2026-04-28doi:10.64898/2026.04.27.26351858Cold Spring Harbor Laboratory Press2026-04-28
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Distinct virus-derived circular RNA molecule influences host response during SARS-CoV-2 infection
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https://www.biorxiv.org/content/10.64898/2026.04.28.721328v1?rss=1"
Grossi-Soyster, E. N.Gullberg, R. C.Rustagi, A.Lee, J. S.Blish, C. A.Cherry, S.Salzman, J.Sarnow, P.2026-04-28doi:10.64898/2026.04.28.721328Cold Spring Harbor Laboratory Press2026-04-28
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Disentangling Fatigue from Depression among Survivors of Severe COVID-19
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https://www.medrxiv.org/content/10.64898/2026.04.24.26351694v1?rss=1"
Cabrera, J. R.Pham, P.Boscardin, W. J.Makam, A. N.2026-04-27doi:10.64898/2026.04.24.26351694Cold Spring Harbor Laboratory Press2026-04-27
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Inhibiting the interaction between the mitochondrial receptor Tom70 and SARS CoV 2 Orf9b with small molecules
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https://www.biorxiv.org/content/10.64898/2026.04.27.721040v1?rss=1"
San Felipe, C.Verba, K. A.Krogan, N. J.Grabe, M.Fraser, J. S.2026-04-27doi:10.64898/2026.04.27.721040Cold Spring Harbor Laboratory Press2026-04-27
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Identifying clinician perceived priorities for a real-time wearable system for in-hospital monitoring: findings and evolutions following the COVID-19 pandemic
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https://www.medrxiv.org/content/10.64898/2026.04.21.26350610v1?rss=1"
Vollam, S.Roman, C.King, E.Tarassenko, L.2026-04-24doi:10.64898/2026.04.21.26350610Cold Spring Harbor Laboratory Press2026-04-24
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Identifying SARS-CoV-2 Lineages that Share the Same Relative Effective Reproduction Numbers
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https://www.medrxiv.org/content/10.64898/2026.04.22.26351531v1?rss=1"
Musonda, R.Ito, K.Omori, R.Ito, K.2026-04-24doi:10.64898/2026.04.22.26351531Cold Spring Harbor Laboratory Press2026-04-24
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Bacteriocin Diversity and Antiviral Potential of Lactiplantibacillus pentosus from Fermented Rice.
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https://www.biorxiv.org/content/10.64898/2026.04.22.720035v1?rss=1"
Cheruvari, A.kammara, R.2026-04-24doi:10.64898/2026.04.22.720035Cold Spring Harbor Laboratory Press2026-04-24
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Proximity proteomics reveals a role for IFI16 during human coronavirus infection
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https://www.biorxiv.org/content/10.64898/2026.04.22.720112v1?rss=1"
Languon, S.Bailey, I.Sorensen, M.Miller, Z. D.Sha, J.Dearborn, J.Dowell, W.Kirch, T.Wohlschlegel, J.MAJUMDAR, D.2026-04-23doi:10.64898/2026.04.22.720112Cold Spring Harbor Laboratory Press2026-04-23
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Diagnostic Classification for Long Covid Patients identifying Persistent Virus and Hyperimmune Pathophysiologies
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https://www.medrxiv.org/content/10.64898/2026.04.21.26351402v1?rss=1"
James-Pemberton, P.Harper, D.Wagerfield, P.Watson, C.Hervada, L.Kohli, S.Alder, S.Shaw, A.2026-04-22doi:10.64898/2026.04.21.26351402Cold Spring Harbor Laboratory Press2026-04-22
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Unique nasal cell states induced by common pediatric respiratory viruses
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https://www.biorxiv.org/content/10.64898/2026.04.20.719671v1?rss=1"
Walsh, J. M. L.Juttukonda, L. J.Tang, Y.Chatterjee, A.Elosua-Bayes, M.Langan, E.Frischmann, A.Taliaferro, F.Matthews, H. R.Kimler, K.Lent, C. M.Purna Keya, D.Chondrow Dev, P.Rajib Malaker, A.Tanvia, L.Mohammad Tanmoy, A.Ghosh, S.Maitra, A.Ghosh, A.Basu, S.Kane, A. S.Coomer, C. A.Shalek, A. K.de Silva, T. I.Sesay, A. K.Edwards, J.Sin Quee, C.Gonzalez, W. I.Yonker, L. M.Glover, S. C.Majumder, P.Hooda, Y.Saha, S.Ordovas-Montanes, J.Horwitz, B. H.2026-04-22doi:10.64898/2026.04.20.719671Cold Spring Harbor Laboratory Press2026-04-22
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Long-range allosteric communication, double mutant cycles, and energetic coupling in SARS-CoV-2 spike protein
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https://www.biorxiv.org/content/10.64898/2026.04.20.719543v1?rss=1"
Lucas, A.Rayaprolu, V.Mallela, K.2026-04-22doi:10.64898/2026.04.20.719543Cold Spring Harbor Laboratory Press2026-04-22
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A High-Throughput Platform for Rapidly Adapting DNA Aptamers to SARS-CoV-2 Evolution
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https://www.biorxiv.org/content/10.64898/2026.04.21.719937v1?rss=1"
He, Y.Yang, Z.Kuo, Y.-A.Wu, Y.Fonseca-Albert, D.Le, K. K.Guo, J. G.Wang, Y.Nguyen, A.-T.Chen, Y.-I.Kim, S.Chen, W.-R.Seifi, S.Hong, S.Nguyen, T. D.Chen, Y.Ren, P.Lu, Y.Yeh, H.-C.2026-04-22doi:10.64898/2026.04.21.719937Cold Spring Harbor Laboratory Press2026-04-22
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Modeling the impact of adherence to U.S. isolation and masking guidance on SARS-CoV-2 transmission in office workplaces in 2021-2022
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https://www.medrxiv.org/content/10.64898/2026.04.14.26350639v1?rss=1"
Garcia Quesada, M.Wallrafen-Sam, K.Kiti, M. C.Ahmed, F.Aguolu, O. G.Ahmed, N.Omer, S. B.Lopman, B. A.Jenness, S. M.2026-04-21doi:10.64898/2026.04.14.26350639Cold Spring Harbor Laboratory Press2026-04-21
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SARS-CoV-2 spike protein-associated sialoglycoconjugates induce nanoscale filipodia to facilitate micro-size platelet clotting
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https://www.biorxiv.org/content/10.64898/2026.04.19.719510v1?rss=1"
Bake, A.Sanaubarova, A.Spillings, B. L.Bremaud, E.Masic, V.Dirr, L.von Itzstein, M.Mak, J.2026-04-20doi:10.64898/2026.04.19.719510Cold Spring Harbor Laboratory Press2026-04-20
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Conserved metabolic vulnerabilities across pathogenic coronaviruses nominate host-directed therapeutic targets
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https://www.biorxiv.org/content/10.64898/2026.04.17.716662v1?rss=1"
Dohai, B.El Assal, D. C.Kang, M.Jaiswal, A.Poulet, C.Daakour, S.Nelson, D. R.Falter-Braun, P.Twizere, J.-C.Salehi-Ashtiani, K.2026-04-20doi:10.64898/2026.04.17.716662Cold Spring Harbor Laboratory Press2026-04-20
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Systematic evaluation of 24 extraction and library preparation combinations for metagenomic sequencing of SARS-CoV-2 in saliva
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https://www.biorxiv.org/content/10.64898/2026.04.16.719115v1?rss=1"
Qian, K.Abhyankar, V.Keo, D.Zarceno, P.Toy, T.Eskin, E.Arboleda, V. A.2026-04-20doi:10.64898/2026.04.16.719115Cold Spring Harbor Laboratory Press2026-04-20
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Evolving concerns about the COVID-19 pandemic: A content analysis of free-text reports from the UK COVID-19 Public Experiences (COPE) study cohort over a two-year period
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https://www.medrxiv.org/content/10.64898/2026.04.16.26351013v1?rss=1"
Phillips, R.Wood, F.Torrens-Burton, A.Glennan, C.Sellars, P.Lowe, S.Caffoor, A.Hallingberg, B.Gillespie, D.Shepherd, V.Poortinga, W.Wahl-Jorgensen, K.Williams, D.2026-04-19doi:10.64898/2026.04.16.26351013Cold Spring Harbor Laboratory Press2026-04-19
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Impact of COVID-19 pandemic on childhood immunization coverage in Indonesia: lesson learned from a nationwide analysis of the Expanded Programme on Immunization
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https://www.medrxiv.org/content/10.64898/2026.04.16.26350989v1?rss=1"
Nurina, A.Puspaningrum, E.Tandy, G.Pattilima, D.Hegar, B.Wangge, G.Hamers, R.Elyazar, I.Surendra, H.2026-04-18doi:10.64898/2026.04.16.26350989Cold Spring Harbor Laboratory Press2026-04-18
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Combined Effects of Severe Immunocompromise and Prolonged Virus Shedding on Within-Host SARS-CoV-2 Evolution in COVID-19
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https://www.medrxiv.org/content/10.64898/2026.04.14.26350918v1?rss=1"
Hirata, Y.Takahashi, K.Iwamoto, N.Dam Jeong, Y.Miyamoto, S.Kawasaki, J.Mine, S.Iida, S.Saito, S.Ainai, A.Kanno, T.Katano, H.Sasaki, N.Horiba, K.Ishikane, M.Kamegai, K.Harrison, M. T.Itoh, N.Akazawa, N.Okumura, N.Haraguchi, M.Sakoh, T.Morishima, M.Araoka, H.Uchida, N.Hase, R.Marumo, Y.Adachi, T.Matsue, K.Saito, T.Ohmagari, N.Iwami, S.Suzuki, T.2026-04-17doi:10.64898/2026.04.14.26350918Cold Spring Harbor Laboratory Press2026-04-1721 days) was found in 14.8% of moderately immunocompromised cases and 72.1% of severely immunocompromised cases. Frequent single-nucleotide variants accumulated specifically in severely immunocompromised individuals with the long shedding phenotype, correlating positively with shedding duration. By contrast, mutations remained limited in moderately immunocompromised individuals with the long shedding phenotype and in severely immunocompromised individuals with the intermediate shedding phenotype. We identified mutations in the spike receptor-binding domain associated with monoclonal antibody resistance; however, we found no fitness-enhancing mutations for inter-host transmission, and antiviral drug resistance mutations were rare. Instead, mutations were introduced frequently and randomly across the entire viral genome.
ConclusionsProlonged upper respiratory virus shedding exceeding 21 days combined with severe immunocompromise is a risk factor of the accumulation of within-host SARS-CoV-2 mutations. Although no variants of concern emerged, the introduction of genome-wide random mutations suggests that the risk for novel variant generation cannot be excluded. These findings highlight the need for intensive antiviral strategies to limit shedding duration to less than 21 days in severely immunocompromised patients, and for immunological investigations to elucidate the host factors underlying residual shedding control in those who achieve clearance within this threshold.
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Understanding inequalities in COVID-19 vaccination between migrants and non-migrants in Germany: The role of psychological factors of vaccine behaviour
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https://www.medrxiv.org/content/10.64898/2026.04.15.26350844v1?rss=1"
Bartig, S.Siegert, M.Hoevener, C.Michalski, N.2026-04-17doi:10.64898/2026.04.15.26350844Cold Spring Harbor Laboratory Press2026-04-17
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Transmission dynamics of the COVID-19 pandemic across the emerging variants in mainland China: a hypergraph-based spatiotemporal modeling study
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https://www.medrxiv.org/content/10.64898/2026.04.16.26351004v1?rss=1"
Wang, Y.WANG, D.Lau, Y. C.Du, Z.Cowling, B. J.Zhao, Y.Ali, S. T.2026-04-17doi:10.64898/2026.04.16.26351004Cold Spring Harbor Laboratory Press2026-04-17
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SARS-CoV-2 neutralising antibody profiles reveal variant specific antibody dynamics and regional differences in infection histories in Malawi
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https://www.medrxiv.org/content/10.64898/2026.04.16.26351029v1?rss=1"
McCormack, M. J.Banda, L.Kasenda, S.Hughes, E. C.Crampin, A. C.Amoah, A. S.Read, J. M.Ho, A.Willett, B. J.Hay, J. A.2026-04-17doi:10.64898/2026.04.16.26351029Cold Spring Harbor Laboratory Press2026-04-17
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SPLIT: Safety Prioritization for Long COVID Drug Repurposing via a Causal Integrated Targeting Framework
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https://www.medrxiv.org/content/10.64898/2026.04.12.26350701v1?rss=1"
Pinero, S. L.Li, X.Lee, S. H.Liu, L.Li, J.Le, T. D.2026-04-16doi:10.64898/2026.04.12.26350701Cold Spring Harbor Laboratory Press2026-04-16
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Effectiveness of 2025-2026 mRNA-1283 and BNT162b2 COVID-19 Vaccines Against COVID-19 Related Hospitalizations and Medically-Attended COVID-19 Among Adults Aged >= 65 years in the United States
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https://www.medrxiv.org/content/10.64898/2026.04.13.26350772v1?rss=1"
Vicic, N.Bogdanov, A.Hensler, H.Ryan, T.Zeng, N.Beck, E.Patry, E.Bonafede, M.Araujo, A. B.Wilson, A.2026-04-16doi:10.64898/2026.04.13.26350772= 65 years in the United States]]>Cold Spring Harbor Laboratory Press2026-04-16
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Cognitive Profiling and Validation of a Digital Cognitive Assessment Tool in Post-COVID-19 Condition: Protocol for a Single-Center, Cross-Sectional Study (DigiCog Study)
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https://www.medrxiv.org/content/10.64898/2026.04.14.26350862v1?rss=1"
Lacomba-Arnau, E.Da Rocha Oliveira, R.Monteiro, S.Pauly, C.Vaillant, M.Celebic, A.Bulaev, D.Fischer, A.Fagherazzi, G.Fernandez, G.Shulz, M.Perquin, M.2026-04-16doi:10.64898/2026.04.14.26350862Cold Spring Harbor Laboratory Press2026-04-16
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Repeated SARS-CoV-2 Antigenic Exposures from Prior Vaccinations and Infections Demonstrate Limits of Antibody Durability and Breadth Against Newer Variants
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https://www.biorxiv.org/content/10.64898/2026.04.15.718804v1?rss=1"
WANG, W.Goguet, e.Lusvarghi, S.Paz, S.Shrestha, L.Vassell, R.Pollett, S.Mitre, E.Weiss, C. D.2026-04-16doi:10.64898/2026.04.15.718804Cold Spring Harbor Laboratory Press2026-04-16
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Mechanistic insights into the association and activation of the SARS-CoV-2 2'-O-Methyltransferase (NSP16)
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https://www.biorxiv.org/content/10.64898/2026.04.15.718757v1?rss=1"
Ma, H.Brace, A.Lemus, M. R.Chennubhotla, S. C.Satchell, K. J.Ramanathan, A.2026-04-16doi:10.64898/2026.04.15.718757Cold Spring Harbor Laboratory Press2026-04-16
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Tracing cell communication programs across conditions at single cell resolution with CCC-RISE
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https://www.biorxiv.org/content/10.64898/2026.04.14.718551v1?rss=1"
Ramirez, A.Thomas, N.Calabrese, D. R.Greenland, J. R.Meyer, A. S.2026-04-15doi:10.64898/2026.04.14.718551Cold Spring Harbor Laboratory Press2026-04-15
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Risk of Post-acute Symptoms and Conditions After SARS-CoV-2 Compared to Other Respiratory Viral Infections: A Systematic Review and Meta-Analysis
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https://www.medrxiv.org/content/10.64898/2026.04.11.26350682v1?rss=1"
Pinto, T. F.Santoro, A.Oliveira, A. L. G.Tavares, T. S.Almeida, A.Incardona, F.Marchetti, G.Cozzi-Lepri, A.Pinto, J.Caporali, J. F. M.2026-04-13doi:10.64898/2026.04.11.26350682Cold Spring Harbor Laboratory Press2026-04-13
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Classifying and Differentiating Individuals with Respiratory Syncytial Virus, Influenza, and COVID-19 Cases in OpenSAFELY
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https://www.medrxiv.org/content/10.64898/2026.04.09.26350495v1?rss=1"
Prestige, E.Warren-Gash, C.Quint, J. K.Evans, D.Costello, R. E.Mehrkar, A.Bacon, S.Goldacre, B.Barley-McMullen, S.Yameen, F.Shah, P.Natt, M.Alder, Y.Hulme, W.Parker, E. P. K.Eggo, R. M.2026-04-13doi:10.64898/2026.04.09.26350495Cold Spring Harbor Laboratory Press2026-04-13
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SARS-CoV-2 Introductions into Lao PDR Revealed by Genomic Surveillance, 2021-2024
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https://www.medrxiv.org/content/10.64898/2026.04.09.26349480v1?rss=1"
Panapruksachat, S.Troupin, C.Souksavanh, M.Keeratipusana, C.Vongsouvath, M.Vongphachanh, S.Vongsouvath, M.Phommasone, K.Somlor, S.Robinson, M. T.Chookajorn, T.Kochakarn, T.Day, N. P.Mayxay, M.Letizia, A. G.Dubot-Peres, A.Ashley, E. A.Buchy, P.Xangsayarath, P.Batty, E. M.2026-04-13doi:10.64898/2026.04.09.26349480Cold Spring Harbor Laboratory Press2026-04-13
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Comparative LUSZ Therapeutic Study (LUSZ_AVIST) of Antiviral, Antiretroviral, and Immunosuppressive Treatments in Hospitalized COVID-19 Patients with High-Risk Factors, Biomarkers, and Disease Progression.
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https://www.medrxiv.org/content/10.64898/2026.04.10.26350587v1?rss=1"
Makdissy, N.Makdessi, E. W.Fenianos, F.Nasreddine, N.Daher, W.El Hamoui, S.2026-04-13doi:10.64898/2026.04.10.26350587Cold Spring Harbor Laboratory Press2026-04-13
<![CDATA[
Loss of host factor-mediated m6Am methylation of the viral RNA cap impairs SARS CoV-2 replication
]]>
https://www.biorxiv.org/content/10.64898/2026.04.10.717462v1?rss=1"
Pandey, R. R.Ebert, N.Homolka, D.Barut, T.Trueeb, B.Stalder, H.Delfino, E.Vagbo, C.Veiga, I.Leidel, S.Thiel, V.Pillai, R.2026-04-13doi:10.64898/2026.04.10.717462Cold Spring Harbor Laboratory Press2026-04-13
<![CDATA[
Integrated Computational and Experimental Evaluation of selected Flavonoids as a Multi-Target Modulator of Viral Entry and Protease Activity.
]]>
https://www.biorxiv.org/content/10.64898/2026.04.10.717575v1?rss=1"
Mohseni-Motlagh, A.Alereza, T.Mozaffari, L.Rozbeh, M.2026-04-13doi:10.64898/2026.04.10.717575Cold Spring Harbor Laboratory Press2026-04-13
<![CDATA[
Serial vaccination expands and refines human CD4+ T cell memory
]]>
https://www.biorxiv.org/content/10.64898/2026.04.11.716570v1?rss=1"
Lai, Y.-H.Su, X.Awad, S.Ansari, A.Jang, J.Saber, A. O.Chen, H.-W.Jung, H.Sarkar, A.Drapeau, E. M.Bilker, W. B.Hensley, S. E.Su, L. F.2026-04-13doi:10.64898/2026.04.11.716570Cold Spring Harbor Laboratory Press2026-04-13
<![CDATA[
MIMIQ: Fast mutual information calculation and significance testing for single-cell RNA sequencing analysis
]]>
https://www.biorxiv.org/content/10.64898/2026.04.10.717770v1?rss=1"
O'Hanlon, D.Garcia Busto, S.Perez Carrasco, R.2026-04-13doi:10.64898/2026.04.10.717770Cold Spring Harbor Laboratory Press2026-04-13
<![CDATA[
Comprehensive Immunophenotyping of Monocytes and Dendritic Cells Suggests Distinct Pathophysiology in Chronic Fatigue Syndrome and Long COVID
]]>
https://www.medrxiv.org/content/10.64898/2026.04.10.26350613v1?rss=1"
Petrov, S. I.Bozhkova, M.Ivanovska, M.Kalfova, T.Dudova, D.Todorova, Y.Dimitrova, R.Murdjeva, M.Taskov, H.Nikolova, M.Maes, M.2026-04-12doi:10.64898/2026.04.10.26350613Cold Spring Harbor Laboratory Press2026-04-12
<![CDATA[
Minor Consent state policies and COVID-19 vaccination in adolescents
]]>
https://www.medrxiv.org/content/10.64898/2026.04.10.26350608v1?rss=1"
Litchy, C.Semprini, J.2026-04-11doi:10.64898/2026.04.10.26350608Cold Spring Harbor Laboratory Press2026-04-11
<![CDATA[
Phagocytic Clearance of SARS-CoV-2 Nucleocapsid- and RNA-Containing Immune Complexes Drives Inflammatory Cytokine Production and Endothelial Dysfunction
]]>
https://www.biorxiv.org/content/10.64898/2026.04.09.717495v1?rss=1"
Gach, J. S.Kim, D.Vu, K.Marshall, M. E.Cachay, C.Rangwala, A. A.Kerster, G.Tifrea, D.Pearlman, E.van Gils, M.Hughes, C. C.Forthal, D. N.2026-04-10doi:10.64898/2026.04.09.717495Cold Spring Harbor Laboratory Press2026-04-10
<![CDATA[
Role of Nonneutralizing Antibodies and Fc Effector Functions in Inhibiting SARS-CoV-2 Infection
]]>
https://www.biorxiv.org/content/10.64898/2026.04.08.717316v1?rss=1"
Sun, H.Esqueda, A.Steinkellner, H.Chen, Q.2026-04-09doi:10.64898/2026.04.08.717316Cold Spring Harbor Laboratory Press2026-04-09
<![CDATA[
An imaging flow cytometry method to study platelet-monocyte aggregates using Long COVID as a model
]]>
https://www.biorxiv.org/content/10.64898/2026.04.09.717442v1?rss=1"
Thompon, A.Venter, C.de Villiers, W. J.De Swardt, D.Laubscher, G. J.Kell, D. B.Pretorius, E.2026-04-09doi:10.64898/2026.04.09.717442Cold Spring Harbor Laboratory Press2026-04-09
<![CDATA[
Myeloma and therapy reshape the bone marrow niche to durably constrain immune reconstitution and vaccine responsiveness
]]>
https://www.biorxiv.org/content/10.64898/2026.04.08.717307v1?rss=1"
Chander, A.Rachid Zaim, S.Dillon, M. A.Genge, P. C.Moss, N.McGrath, P. I.Kopp, M. S.Lee, K. J.Kuan, E. L.Reading, J.Hernandez, V.Song, X.Singh, M.Garber, J.LaFrance, C. M.Kong, G. L.Glass, M. C.Davis, E. L. W.Glass, D.He, Y. D.Heubeck, A. T.Kawelo, E. K.Krishnan, U.Lord, C.Meijer, P.Mettey, R. R.Musgrove, B.Okada, L. Y.Parthasarathy, V.Peng, T.Phalen, C. G.Riddell, S.Roll, C. R.Stuckey, T. J.Swanson, E. G.Thomson, Z. J.Weiss, M. D. A.Wittig, P. J.Anover-Sombke, S. D.Coffey, E. M.Becker, L. A.Bumol, T. F.Goldrath, A. W.Newell, E. W.Greenberg, P. D.Li, X.-j.Kaech, S. M.Skene, P. J.Graybuck, L. T.Tatting, L.Sigvardsson, M.Kwok, M.Green, D. J.Torgerson, T. R.Angus-Hill, M. L.2026-04-09doi:10.64898/2026.04.08.717307Cold Spring Harbor Laboratory Press2026-04-09
<![CDATA[
Assessing the Impact of Timing and Coverage of United States COVID-19 Vaccination Campaigns: A Multi-Model Approach
]]>
https://www.medrxiv.org/content/10.64898/2026.04.07.26349269v1?rss=1"
Nande, A.Larsen, S. L.Turtle, J.Davis, J. T.Bandekar, S. R.Lewis, B.Chen, S.Contamin, L.Jung, S.-m.Howerton, E.Shea, K.Bay, C.Ben-Nun, M.Bi, K.Bouchnita, A.Chen, J.Chinazzi, M.Fox, S. J.Hill, A. L.Hochheiser, H.Lemaitre, J. C.Loo, S. L.Marathe, M.Meyers, L. A.Pearson, C. A. B.Porebski, P.Przykucki, E.Smith, C. P.Venkatramanan, S.Vespignani, A.Willard, T. C.Yan, K.Viboud, C.Lessler, J.Truelove, S.2026-04-08doi:10.64898/2026.04.07.26349269Cold Spring Harbor Laboratory Press2026-04-08
<![CDATA[
Intranasal Anti-CD3 Antibody Treatment Attenuates Post-COVID Neuroinflammation and Enhances Hippocampal Neurogenesis and Cognitive Function in Mice
]]>
https://www.biorxiv.org/content/10.64898/2026.04.07.716934v1?rss=1"
Lu, P.Izzy, S.Da Silva, P.Imkamp, H. T.Christenson, J. R.Yahya, T.Mansi, M. H. A.Alawi, A.Moreira, T. G.Monje, M.Weiner, H. L.Iwasaki, A.2026-04-08doi:10.64898/2026.04.07.716934Cold Spring Harbor Laboratory Press2026-04-08
<![CDATA[
SKIN AS A POTENTIAL ENTRY POINT FOR SARS-COV-2
]]>
https://www.biorxiv.org/content/10.64898/2026.04.07.717019v1?rss=1"
Trubestskoy, D.Grudzien, P.Chudakova, D.Klopot, A.Bhalla, P.Perez-White, B.Budunova, I.2026-04-08doi:10.64898/2026.04.07.717019Cold Spring Harbor Laboratory Press2026-04-08
<![CDATA[
High-speed 3D single-virus tracking reveals actin-aided viral trafficking of SARS-CoV-2 on the plasma membrane
]]>
https://www.biorxiv.org/content/10.64898/2026.04.03.716319v1?rss=1"
Lin, Y.Lu, X.Exell, J.Lin, H.Johnson, C.Welsher, K.2026-04-06doi:10.64898/2026.04.03.716319Cold Spring Harbor Laboratory Press2026-04-06
<![CDATA[
Frustration Landscapes of Broadly Neutralizing SARS-CoV-2 Spike Antibodies Targeting Conserved Epitopes Reveal Energetic Logic of Escape-Proof and Escape-Prone Mechanisms
]]>
https://www.biorxiv.org/content/10.64898/2026.04.02.716254v1?rss=1"
Alshahrani, M.Gatlin, W.Ludwick, M.Turano, L.Foley, B.Verkhivker, G.2026-04-03doi:10.64898/2026.04.02.716254Cold Spring Harbor Laboratory Press2026-04-03
<![CDATA[
The transmembrane domain regulates the kinetics of the SARS-CoV-2 spike conformational transition
]]>
https://www.biorxiv.org/content/10.64898/2026.04.03.716256v1?rss=1"
Kulshrestha, A.Banerjee, A.Lall, S.Gosavi, S.2026-04-03doi:10.64898/2026.04.03.716256Cold Spring Harbor Laboratory Press2026-04-03
<![CDATA[
Machine Learning-Driven Antigen Selection Reveals Conserved T-Cell Targets for Broad Coronavirus Vaccination
]]>
https://www.biorxiv.org/content/10.64898/2026.04.02.716054v1?rss=1"
Federico, L.Odainic, A.Lund, K. P.Egner, I. M.Wiese, K. E.Cornelissen, L. A. H. M.Kared, H.Stratford, R.Kapell, S.Malone, B.Gheorghe, M.Machart, P.Siarheyeu, R.Tanaka, Y.Clancy, T.Bendjama, K.Munthe, L. A.2026-04-03doi:10.64898/2026.04.02.716054Cold Spring Harbor Laboratory Press2026-04-03
<![CDATA[
TF-IDF k-mer-based Classical and Hybrid Machine Learning Models for SARS-CoV-2 Variant Classification under Imbalanced Genomic Data
]]>
https://www.biorxiv.org/content/10.64898/2026.04.02.716024v1?rss=1"
Haque, N.Mazed, A.Ankhi, J. N.Uddin, M. J.2026-04-02doi:10.64898/2026.04.02.716024Cold Spring Harbor Laboratory Press2026-04-02
<![CDATA[
Conserved stem-loops of the SARS-CoV-2 5'-UTR activate OAS1
]]>
https://www.biorxiv.org/content/10.64898/2026.04.01.715984v1?rss=1"
Oviedo, A.Bair, C. R.Vasilakopoulos, A. P.Regis, K.VanInsberghe, D.Lowen, A. C.Conn, G. L.2026-04-02doi:10.64898/2026.04.01.715984Cold Spring Harbor Laboratory Press2026-04-02
<![CDATA[
VYD2311 is a promising candidate for passive immunization against COVID-19 in immunocompromised individuals
]]>
https://www.biorxiv.org/content/10.64898/2026.03.31.715419v1?rss=1"
Mellis, I. A.Wu, M.Daniel, K.Hong, H.Guo, Y.Ho, D. D.2026-04-01doi:10.64898/2026.03.31.715419Cold Spring Harbor Laboratory Press2026-04-01
<![CDATA[
Omicron-Enhanced Immunosuppressive Effects of SARS-CoV-2 ORF3a and ORF9b Accessory Proteins on Monocytic Inflammatory Response
]]>
https://www.biorxiv.org/content/10.64898/2026.03.31.715496v1?rss=1"
Grigas, J.Padilla-Blanco, M.Herran, U. M.Lopez-Ayllon, B. D.Rius, A. d. L.Mendoza Garcia, L.Fernandez Rodriguez, R.Garcia Garcia, T.Garrido, J. J.Pautienius, A.Stankevicius, A.Kucinskaite-Kodze, I.Montoya, M.2026-04-01doi:10.64898/2026.03.31.715496Cold Spring Harbor Laboratory Press2026-04-01
<![CDATA[
Intranasal immunization with live-attenuated RSV-vectored SARS-CoV-2 vaccines elicits antigen-specific systemic and mucosal immunity and protects against viral challenge and natural infection
]]>
https://www.biorxiv.org/content/10.64898/2026.03.30.715311v1?rss=1"
Botta, D.Schultz, M. D.Silva-Sanchez, A.Kalange, D.Akther, J.Zhou, F.Tipper, J. L.Yang, G.Schaefers, L. T.Barkley, C. A.Qiu, S.Foote, J. B.Tioni, M. F.Weiss, C. M.Phan, S. I.Green, T. J.Leal, S. M.Harrod, K. S.King, R. G.Moore, M. L.Randall, T. D.Tang, R. S.Lund, F. E.2026-03-31doi:10.64898/2026.03.30.715311Cold Spring Harbor Laboratory Press2026-03-31
<![CDATA[
Increased Risk of Pulmonary Embolism Following SARS-CoV-2 Activity in Ontario, Canada
]]>
https://www.medrxiv.org/content/10.64898/2026.03.27.26349516v1?rss=1"
Lee, C. E.Wilson, N. J.Fisman, D.2026-03-30doi:10.64898/2026.03.27.26349516Cold Spring Harbor Laboratory Press2026-03-30
<![CDATA[
Twelve Distinct Laboratory Methods Used to Measure SARS-CoV-2 in Wastewaters throughout a Three-Year Ontario-Wide, Canada Study: Impact on Public Health Interpretation of Disease Incidence
]]>
https://www.medrxiv.org/content/10.64898/2026.03.27.26349524v1?rss=1"
Hegazy, N.Peng, K. K.de Haan-Ward, J.Renouf, E.Mercier, E.Wan, S.Hu, X. J.Dean, C.Servos, M.Edwards, E.Ybazeta, G.Habash, M.Goodridge, L.Brown, R. S.Payne, S. J.Kirkwood, A.Kyle, C.McKay, R. M.Gilbride, K.DeGroot, C.Delatolla, R.2026-03-30doi:10.64898/2026.03.27.26349524Cold Spring Harbor Laboratory Press2026-03-30
<![CDATA[
Panmap: Scalable phylogeny-guided alignment, genotyping, and placement on pangenomes
]]>
https://www.biorxiv.org/content/10.64898/2026.03.29.711974v1?rss=1"
Kramer, A. M.Zhang, A.Ayala, N.de Sanctis, B.Karim, L. M.Hinrichs, A. S.Walia, S.Turakhia, Y.Corbett-Detig, R.2026-03-30doi:10.64898/2026.03.29.711974Cold Spring Harbor Laboratory Press2026-03-30
<![CDATA[
Structure of SARS-CoV-2 spike in complex with its co-receptor the neuronal cell adhesion protein contactin 1
]]>
https://www.biorxiv.org/content/10.64898/2026.03.28.714969v1?rss=1"
Krepel, S. T.Hurdiss, D. L.Bosch, B. J.Snijder, J.Janssen, B. J. C.2026-03-29doi:10.64898/2026.03.28.714969Cold Spring Harbor Laboratory Press2026-03-29
<![CDATA[
Characterization of Self-Incompatibility Genes in Brassica rapa var. Toria and Yellow sarson
]]>
https://www.biorxiv.org/content/10.64898/2026.03.25.714316v1?rss=1"
Bhalla, H.Ankita, K.Ahlawat, A.Rode, S. S.Singh, K. H.Sankaranarayanan, S.2026-03-28doi:10.64898/2026.03.25.714316Cold Spring Harbor Laboratory Press2026-03-28
<![CDATA[
A protocol for assessment of interventions using a computational phenotype for Long COVID
]]>
https://www.medrxiv.org/content/10.64898/2026.03.26.26347671v1?rss=1"
Amitabh Gunjan, A.Huang, L.Appe, A.McKelvey, P. A.Algren, H. A.Berry, M.Mozaffari, E.Wright, B. J.Hadlock, J. J.Goldman, J. D.2026-03-27doi:10.64898/2026.03.26.26347671Cold Spring Harbor Laboratory Press2026-03-27 2) included thromboembolism, hair loss, diabetes mellitus, obesity, and hypoxia. Anosmia/dysgeusia was associated with COVID, but wide confidence intervals reflected few charted diagnoses.
ConclusionsManifestations of Long COVID at population scale are detectable as part of routine symptoms and clinical diagnoses in the EHR after admissions for COVID-19, compared with all other hospital admissions. This a prior computational phenotype for Long COVID will be used to assess whether remdesivir use is associated with decreased Long COVID.
]]>
<![CDATA[
Impact of viral membrane oxidation on SARS-CoV-2 spike protein transmembrane anchoring stability
]]>
https://www.biorxiv.org/content/10.64898/2026.03.27.714475v1?rss=1"
Ghasemitarei, M.Gyursanszky, C.Karttunen, M.Ala-Nissila, T.2026-03-27doi:10.64898/2026.03.27.714475Cold Spring Harbor Laboratory Press2026-03-2710 lipids) identified via RDF-based clustering. These oxidation-induced changes reduce hydrophobic matching around the TM helix and facilitate its extraction from the viral envelope. Our results provide a mechanistic link between lipid peroxidation, membrane nanostructure, and spike anchoring, supporting lipid oxidation for example during cold atmospheric plasma or ozone treatment as a physically grounded contributing antiviral mechanism against SARS-CoV-2.
]]>
<![CDATA[
An Assessment of Correctional Officer's Health Beliefs in Relationship to COVID-19 Vaccine Uptake and Hesitancy.
]]>
https://www.medrxiv.org/content/10.64898/2026.03.24.26349101v1?rss=1"
Hedden-Clayton, B.Roddy, A. L.Roddy, J. K.Ngassa, Y.Pickard, B.Tam, R. A.Wurcel, A. G.2026-03-26doi:10.64898/2026.03.24.26349101Cold Spring Harbor Laboratory Press2026-03-26
<![CDATA[
Disentangling the Shared and Differential Genetic Architecture Between COVID-19 and Other Respiratory Disorders: A Multi-Omics Genome-Wide Analysis
]]>
https://www.medrxiv.org/content/10.64898/2026.03.21.26348591v1?rss=1"
Xue, X.LIN, Y.-P.FENG, Y.SO, H.-C.2026-03-26doi:10.64898/2026.03.21.26348591Cold Spring Harbor Laboratory Press2026-03-26
<![CDATA[
A Demographic Look at Cancer Treatment Behaviors during the COVID-19 Pandemic
]]>
https://www.medrxiv.org/content/10.64898/2026.03.24.26349229v1?rss=1"
Acosta Morales, J. M.2026-03-26doi:10.64898/2026.03.24.26349229Cold Spring Harbor Laboratory Press2026-03-26
<![CDATA[
Higher SARS-CoV-2 Transmission Burden Among Racialized Individuals: Evidence from Canadian Serology Data
]]>
https://www.medrxiv.org/content/10.64898/2026.03.23.26349092v1?rss=1"
Mann, S. K.Wilson, N. J.Lee, C. E.Fisman, D.2026-03-25doi:10.64898/2026.03.23.26349092Cold Spring Harbor Laboratory Press2026-03-25
<![CDATA[
Beyond COVID-19 Deaths: Cause-Specific Analysis of Excess Mortality in Russia
]]>
https://www.medrxiv.org/content/10.64898/2026.03.23.26349084v1?rss=1"
Degtiareva, E.Timonin, S.Tilstra, A.Aburto, J. M.2026-03-25doi:10.64898/2026.03.23.26349084Cold Spring Harbor Laboratory Press2026-03-25
<![CDATA[
Wastewater-Based Genomic Surveillance of SARS-CoV-2 Variant Circulation in Two Informal Urban Settlements in Nairobi, Kenya
]]>
https://www.medrxiv.org/content/10.64898/2026.03.23.26349096v1?rss=1"
Kingwara, L.Madada, R. S.Morangi, V.Akasa, S.Kiprutto, V.Julie, O.Muthoka, R.Rombo, C.Kimonye, K.Okunga, E.Masika, M.Ochieng, E.Nyaga, R.Otieno, O.Cham, F.Hull, N.Kimenye, K.2026-03-25doi:10.64898/2026.03.23.26349096Cold Spring Harbor Laboratory Press2026-03-25
<![CDATA[
Household Size and Age as Primary Drivers of COVID-19 Infection Among Priority Populations in Australia
]]>
https://www.medrxiv.org/content/10.64898/2026.03.23.26349117v1?rss=1"
Narayanasamy, S.Altermatt, A.Tse, W. C.Gibbs, L.Wilkinson, A.Heath, K.Stoove, M.Scott, N.Gibney, K.Hellard, M.Pedrana, A.2026-03-25doi:10.64898/2026.03.23.26349117Cold Spring Harbor Laboratory Press2026-03-25
<![CDATA[
Phylogenetic Insights into SARS-CoV-2 Introductions and Spread in Georgia
]]>
https://www.medrxiv.org/content/10.64898/2026.03.23.26349139v1?rss=1"
Veytsel, G. E.Lyu, L.Stott, G.Carmola, L.Dishman, H.Bahl, J.2026-03-25doi:10.64898/2026.03.23.26349139Cold Spring Harbor Laboratory Press2026-03-25
<![CDATA[
SARS-CoV-2 PLpro Drives Epithelial Barrier Disruption Across Drosophila and Mammalian Epithelia
]]>
https://www.biorxiv.org/content/10.64898/2026.03.24.713966v1?rss=1"
Ahmad, Q. T.Banerjee, S.Anerao, I. M.Tripathi, J.Parihar, S. S.Bajpai, A.Rizvi, M. S.SINHA, P.2026-03-25doi:10.64898/2026.03.24.713966Cold Spring Harbor Laboratory Press2026-03-25
<![CDATA[
Coronavirus envelope protein drives iron sensing disorder by hijacking the TAp73-FDXR axis
]]>
https://www.biorxiv.org/content/10.64898/2026.03.24.713916v1?rss=1"
Zhu, M.Hu, L.Fu, X.Yuan, B.Guan, G.Han, L.Rong, Z.Tian, R.Li, G.Du, M.Ma, Y.Xu, N.Liu, H.Tian, H.Yin, X.Zhong, J.Sun, M.Yang, S.Liu, S.Liu, Q.Li, J.Fan, B.Chen, Y.Zhao, Q.Zhou, T.Chang, L.Zhao, X.Ran, X.Du, Q.Ding, S.Li, B.Huang, Y.Tong, D.2026-03-25doi:10.64898/2026.03.24.713916Cold Spring Harbor Laboratory Press2026-03-25
<![CDATA[
Somatic evolution of a cross-reactive germline antibody that expands its breadth to neutralize new SARS-CoV-2 variants
]]>
https://www.biorxiv.org/content/10.64898/2026.03.20.713312v1?rss=1"
Lv, H.Feng, Z.Teo, Q. W.Chen, C.Gopal, A. B.Choi, D.Tan, T. J. C.Tang, Y. S.Siu, L.Nourmohammad, A.Bruzzone, R.Wilson, I. A.Yuan, M.Wu, N. C.Mok, C. K.-P.2026-03-25doi:10.64898/2026.03.20.713312Cold Spring Harbor Laboratory Press2026-03-25
<![CDATA[
Modulation of liposome membranes by the C-terminal domain of the coronavirus envelope protein
]]>
https://www.biorxiv.org/content/10.64898/2026.03.23.713574v1?rss=1"
Alag, R.Bui, M. H.Miserez, A.Torres, J.Pervushin, K.Sharma, B.2026-03-25doi:10.64898/2026.03.23.713574Cold Spring Harbor Laboratory Press2026-03-25
<![CDATA[
Shifts in the pathogen spectrum and epidemiology of respiratory tract infections in the post-COVID-19 era: A study from Quzhou, Eastern China
]]>
https://www.medrxiv.org/content/10.64898/2026.03.20.26348947v1?rss=1"
Yang, R.Wang, M.Lyu, L.You, J.Huang, S.Zhan, B.2026-03-24doi:10.64898/2026.03.20.26348947Cold Spring Harbor Laboratory Press2026-03-24
<![CDATA[
Microtesla Magnetic Therapy for cognitive impairment in post-acute sequelae of SARS CoV-2: A randomized controlled feasibility study
]]>
https://www.medrxiv.org/content/10.64898/2026.03.18.26348530v1?rss=1"
Canori, A.Watson, E.Patel, D.Fiorentino, A.Santiago, C.Maltz, D.Gurfein, B.Putrino, D.Becker, J.2026-03-23doi:10.64898/2026.03.18.26348530Cold Spring Harbor Laboratory Press2026-03-23
<![CDATA[
Feasibility, Acceptability, and Cost of Community-Based Self-monitoring among Sex Workers Testing Positive for COVID-19 in Zimbabwe: A Mixed-methods Study.
]]>
https://www.medrxiv.org/content/10.64898/2026.03.16.26348020v1?rss=1"
Kabonga, I.Mangenah, C.Watadzaushe, C.Madanhire, C.Ruhode, N.Dunkley, Y.Karin, H.Corbett, E. L.Cowan, F. M.Sibanda, E. L.2026-03-23doi:10.64898/2026.03.16.26348020Cold Spring Harbor Laboratory Press2026-03-23
<![CDATA[
Resistome, Virulome, Mobilome, And Biosynthetic Gene Clusters Adaptations of Acinetobacter Baumannii Mexican Strains Across the Pre- and of the COVID-19 Period: Insights from Whole-Genome Sequencing
]]>
https://www.biorxiv.org/content/10.64898/2026.03.22.712163v1?rss=1"
Alejo, M. A.Lozano Gamboa, M. S.Munoz Gomez, B. E.Hernandez Magro Gil, K. G.Garcia Contreras, R.Whitaker, R.Palacios Marmolejo, A.Ceapa, C. D.2026-03-23doi:10.64898/2026.03.22.712163Cold Spring Harbor Laboratory Press2026-03-23
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Physiotherapy service during the COVID-19 pandemic in Nepal: An onsite survey and the lived experience among clinicians
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https://www.medrxiv.org/content/10.64898/2026.03.19.26348776v1?rss=1"
Shakya, N. R.Dahal, S.Shrestha, N.Webb, G.Stensdotter, A.-K.2026-03-22doi:10.64898/2026.03.19.26348776Cold Spring Harbor Laboratory Press2026-03-22
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SARS-CoV-2 and the Pandemic Surge in Invasive Group A Streptococcal Disease
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https://www.medrxiv.org/content/10.64898/2026.03.19.26348823v1?rss=1"
Fisman, D.Lee, C. E.Wilson, N.Barton, M.Mann, S. K.Tuite, A.2026-03-22doi:10.64898/2026.03.19.26348823Cold Spring Harbor Laboratory Press2026-03-22
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Autoantibody landscapes in neurological Long COVID and post-COVID cognitive impairment show heterogeneity without a shared disease signature
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https://www.medrxiv.org/content/10.64898/2026.03.19.26348833v1?rss=1"
Chakravarty, D.Dandekar, R.Lashkari, V. D.Tilton, I.McAlpine, L.Chiarella, J.Nelson, A.Ngo, T.Chen, P.Wang, G.Saxena, A.Castillo-Rojas, B.Zorn, K.Tribble, D. R.Burgess, T. H.Rubin, L. H.Richard, S. A.Agan, B. K.Pollett, S. D.Farhadian, S.Spudich, S.Pleasure, S. J.Wilson, M. R.2026-03-22doi:10.64898/2026.03.19.26348833Cold Spring Harbor Laboratory Press2026-03-22
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Prediction of confirmed, hospitalized, and severe COVID-19 cases and mechanistic insights from viral concentrations and variant dynamics in wastewater
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https://www.medrxiv.org/content/10.64898/2026.03.18.26348767v1?rss=1"
Murakami, M.Watanabe, R.Iwamoto, R.Chung, U.-i.Kitajima, M.Yoo, B.-K.2026-03-20doi:10.64898/2026.03.18.26348767Cold Spring Harbor Laboratory Press2026-03-20
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Prenatal exposure to SARS-CoV-2, early relational health, and child socio-emotional functioning in the first 6 months
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https://www.medrxiv.org/content/10.64898/2026.03.12.26346895v1?rss=1"
Lavallee, A.Warmingham, J. M.Owens, J. B.Xu, R. L.Ahmed, I.Atwood, G. D.Kyle, M. H.Hussain, M.Chaves, V.Arduin, E.Lanoff, M. R.Hyman, S. P.Coskun, L. Z.Shearman, N. D.Russo, J. E.Ettinger, S.Greenman, E. A.Serota, D. E.Bence, M. L.Hott, V.Hu, Y.Kurman, G.Lara, M.Tzul Lopez, H.Mollicone, I.Ravi, R.Rodriguez, C.Smotrich, G. C.Lawless, A.Ontiveros-Angel, P.Curtin, A.Austin, J.Firestein, M. R.Shuffery, L. C.Fernandez, C. R.Battarbee, A. N.Bruno, A.Dawood, F. S.Maniatis, P.Morrill, T. C.Newes-Adeyi, G.Reichle, L.Sem2026-03-19doi:10.64898/2026.03.12.26346895Cold Spring Harbor Laboratory Press2026-03-19
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Predictors of COVID-19 hospital outcomes: a machine learning analysis of the National COVID Cohort Collaborative
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https://www.medrxiv.org/content/10.64898/2026.03.06.26347822v1?rss=1"
Vazquez, J.Taylor, L.Chen, Y.-Y. K.Araya, K.Farnsworth, M. G.Xue, X.Hasan, M.N3C Consortium,2026-03-09doi:10.64898/2026.03.06.26347822Cold Spring Harbor Laboratory Press2026-03-09
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Would Lifting Versus Maintaining COVID-19 Containment Policies Have Reduced Psychological Distress in the US?
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https://www.medrxiv.org/content/10.64898/2026.03.06.26347802v1?rss=1"
Cudic, M.de la Hoz, J. F.Dall'Aglio, L.Tubbs, J. D.Ebrahimi, O. V.Madsen, E. M.Fatori, D.Zuccolo, P. F.Lian, J.Kabir, D. K.Zhou, Y.Watts, D.Choi, K. W.Manfro, G. G.Sweeney, E.Lin, Y.-F.Fancourt, D.COVID-19 Global Mental Health Consortium (CGMHC),Patel, V.Kessler, R. C.Bauermeister, S.Brunoni, A. R.Lee, Y. H.Smoller, J. W.2026-03-09doi:10.64898/2026.03.06.26347802Cold Spring Harbor Laboratory Press2026-03-0914 days) pandemic severity. The primary outcome was prevalence of psychological distress, derived from a BRFSS survey item corresponding to a PHQ-4 score [≥]6.
FindingsThree causal inference approaches yielded consistent evidence of transient policy-lifting effects: (1) synthetic control analysis of Maine showed a temporary 5.5 percentage-point reduction in psychological distress lasting three months before returning to counterfactual levels; (2) within-state fixed effects found immediately after lifting full lockdown, distress decreased by 5.68 [-8.67, -2.69] percentage points, declining by 30 days (-3.24 [-6.88, 0.39]) and negligible at 60 days (-0.94 [-3.77, 1.89]); (3) target trial emulation detected no significant effects from lifting versus maintaining policies for 90 days.
InterpretationLifting containment policies in the first year of the pandemic produced immediate but transient reductions in psychological distress. These results suggest that extended containment policies were unlikely to account for persistent increases in distress during this period.
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Chronic absenteeism in Canadian kindergarten classes, pre- and post-COVID-19, and its association with concurrent developmental vulnerability
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https://www.medrxiv.org/content/10.64898/2026.03.04.26347661v1?rss=1"
Reid-Westoby, C.Duku, E.Gaskin, A.Janus, M.2026-03-05doi:10.64898/2026.03.04.26347661Cold Spring Harbor Laboratory Press2026-03-05
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Outburst of serotype 4 IPD after COVID-19 is driven by ST15063/GPSC162 lineage associated with high-risk behaviors and greater virulence linked to influenza H3N2 virus coinfection and cigarette smoke
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https://www.medrxiv.org/content/10.64898/2026.02.27.26346872v1?rss=1"
Perez-Garcia, C.Llorente, J.Aguirre Alustuey, M. E.Llamosi, M.Gil, R.Lahlali, G.El-Ayache, F.Yan, V.Schotsaert, M.Del Diego, J.Cisneros, J. M.Garcia-Sastre, A.Domenech, M.Sempere, J.Yuste, J.2026-03-04doi:10.64898/2026.02.27.26346872Cold Spring Harbor Laboratory Press2026-03-04