Channel:  HHMI

1037 Articles

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality
Tien, J. C.-Y., Chang, Y., Zhang, Y., Chou, J., Cheng, Y., Wang, X., Yang, J., Mannan, R., Shah, P., Wang, X.-M., Todd, A. J., Eyunni, S., Cheng, C., Rebernick, R. J., Xiao, L., Bao, Y., Neiswender, J., Brough, R., Pettitt, S. J., Cao, X., Miner, S. J., Zhou, L., Wu, Y.-M., Labanca, E., Wang, Y., Parolia, A., Cieslik, M., Robinson, D. R., Wang, Z., Feng, F. Y., Lord, C. J., Ding, K., Chinnaiyan, A. M.
10.1101/2024.03.20.585990 — Posted: 2024-03-21
PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes
Singh, S., Dransfeld, U., Ambaw, Y., Lopez-Scarim, J., Farese, R. V., Walther, T. C.
10.1101/2024.03.21.586175 — Posted: 2024-03-21
Effects of protein G-quadruplex interactions on phase transitions and protein aggregation
Sahoo, B., Kocman, V., Clark, N., Myers, N., Deng, X., Wong, E. L., Yang, H. J., Kotar, A., Guzman, B. B., Dominguez, D. C., Plavec, J., Bardwell, J. C.
10.1101/2023.09.21.558871 — Posted: 2024-03-20
Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer
Lee, E., Zhang, Z., Chen, C.-C., Choi, D., Rivera, A. C. A., Linton, E., Ho, Y.-j., Love, J., LaClair, J., Wongvipat, J., Sawyers, C.
10.1101/2024.03.18.585532 — Posted: 2024-03-20
Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer
Cheng, C., Hu, J., Mannan, R., Bhattacharyya, R., Rossiter, N. J., Magnuson, B., Wisniewski, J. P., Zheng, Y., Xiao, L., Li, C., Awad, D., He, T., Bao, Y., Zhang, Y., Cao, X., Wang, Z., Mehra, R., Morlacchi, P., Sahai, V., Pasca di Magliano, M., Shah, Y. M., Ding, K., Qiao, Y., Lyssiotis, C. A., Chinnaiyan, A. M.
10.1101/2024.03.18.585580 — Posted: 2024-03-20
Gut microbiota gate host exposure to metabolites from dietary Solanums
Liou, C. S., Iakiviak, M., Rajniak, J., Murugkar, P. P., Higginbottom, S. K., Jasper, M., Fischbach, M. A., Sattely, E. S.
10.1101/2024.03.20.584512 — Posted: 2024-03-20
Structural and genetic diversity in the secreted mucins, MUC5AC and MUC5B
Plender, E. G., Prodanov, T., Hsieh, P., Nizamis, E., Harvey, W. T., Sulovari, A., Munson, K. M., Kaufman, E., O'Neal, W. K., Valdmanis, P. N., Marschall, T., Eichler, E. E.
10.1101/2024.03.18.585560 — Posted: 2024-03-20
Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model
Xue, Y., Zhou, Y., Cepko, C. L.
10.1101/2023.08.03.551766 — Posted: 2024-03-20
Stable and robust Xi and Y transcriptomes drive cell-type-specific autosomal and Xa responses in vivo and in vitro in four human cell types
Blanton, L. V., San Roman, A. K., Wood, G., Buscetta, A., Banks, N., Skaletsky, H., Godfrey, A. K., Pham, T. T., Hughes, J. F., Brown, L. G., Kruszka, P., Lin, A. E., Kastner, D. L., Muenke, M., Page, D. C.
10.1101/2024.03.18.585578 — Posted: 2024-03-19
Metastatic site influences driver gene function in pancreatic cancer
Tsanov, K. M., Barriga, F. M., Ho, Y.-J., Alonso-Curbelo, D., Livshits, G., Koche, R. P., Baslan, T., Simon, J., Tian, S., Wuest, A. N., Luan, W., Wilkinson, J. E., Masilionis, I., Dimitrova, N., Iacobuzio-Donahue, C. A., Chaligne, R., Pe'er, D., Massague, J., Lowe, S. W.
10.1101/2024.03.17.585402 — Posted: 2024-03-18

RSS  Channel RSS