Channel:  Francis Crick Institute

1,179 Articles

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Single-cell transcriptional dynamics in a living vertebrate
Eck, E., Moretti, B., Schlomann, B. H., Bragantini, J., Lange, M., Zhao, X., VijayKumar, S., Valentin, G., Loureiro, C., Franco, P. P., Jollivet, C., Motomochi, B., Royer, L. A., Oates, A. C., Garcia, H. G.
10.1101/2024.01.03.574108 — Posted: 2025-06-11
Subclonal mutation load predicts survival and response to immunotherapy in cancers with low to moderate tumor mutation burden
Jiang, Y., Montierth, M. D., Yu, K., Ji, S., Tran, Q., Liu, X., Shen, J. P., Guo, S., Wu, A., Dai, Y., Shin, S. J., Li, R., Cao, S., Tang, Y., Lesluyes, T., Kopetz, S., Msaouel, P., Sood, A. K., Devonshire, G., Jones, C. M., Ajani, J., Subudhi, S. K., Aparicio, A., Sharma, P., Shen, J. P., Kimmel, M., Wang, J. R., Tarabichi, M., Fitzgerald, R. C., Zhu, H., Loo, P. V., Wang, W.
10.1101/2024.07.03.601939 — Posted: 2025-06-10
Multimodal profiling unveils a reversible basal-like breast cancer cell state resistant to AKT inhibition
Ratcliffe, C. D. H., Sparks, H., Boezio, G. L. M., Alexandrov, Y., Jenkins, R. P., Le Marois, A., Soro-Barrio, P., Lee, R., Strohbuecker, S., Joshi, S., Ellis, J. K., Fortier, A.-M., Gustafsson, N., Cunha, A. C., Park, M., MacRae, J. I., Serio, A., Briscoe, J., Riddell, A., Barry, S. T., Dunsby, C., Sahai, E.
10.1101/2025.06.06.658331 — Posted: 2025-06-07
Targeting Neutrophil Extracellular Traps to inhibit Colon Cancer Tumor Necrosis and Metastasis
Gazzara, E., Adrover, J. M., Lui, A., Han, S., Aminzada, Z., Bhandari, N., Sivetz, N., Shirue, V. S., Shergill, B. S., Curtis, M. B., George, S. C., Cicala, A., Rishi, A., Chung, C., Devoe, C., Huang, H., Weiss, M., Lou, E., Tuveson, D. A., Beyaz, S., Westcott, P. M. K., Egeblad, M., Gholami, S.
10.1101/2025.05.30.657122 — Posted: 2025-06-07
MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression
Nielsen, J. C., Benito-Jardon, M., Petrela, N. C., Diring, J., Bellamy, S., Treisman, R.
10.1101/2025.06.06.657372 — Posted: 2025-06-07
A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics
Autorino, C., Khoromskaia, D., Harari, L., Floris, E., Booth, H., Pallares-Cartes, C., Petrasiunaite, V., Dorrity, M., Corominas-Murtra, B., Hadjivasiliou, Z., Petridou, N.
10.1101/2025.06.06.658228 — Posted: 2025-06-06
C9orf72 polyGA knock-in mice exhibit mild motor and proteomic changes consistent with ALS/FTD
Milioto, C., Carcole, M., Zanovello, M., Ahmed, M., Nirujogi, R. S., Biggs, D., Katona, E., Glaria, I., Santos, A., Devoy, A., Fratta, P., Alessi, D. R., Davies, B., Greensmith, L., Fisher, E., Isaacs, A. M.
10.1101/2025.05.30.656994 — Posted: 2025-06-02
Lysosomal stress induces amyloid-β aggregate release and reactive transformation in human astrocytes
Goldsworthy, S., Fertan, E., Dyal, P., Domoney, S., Livesey, F., Klenerman, D., Patani, R., Hung, C.
10.1101/2025.05.27.656416 — Posted: 2025-06-01
Beneficial and detrimental consequences of AHR activation in intestinal infection
Diaz, O. P., zhou, L., Barrington, C., Lindquist, D., Graelmann, F., Wincent, E., Stockinger, B.
10.1101/2025.05.28.656570 — Posted: 2025-06-01
The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis
Roeselova, A., Shivakumaraswamy, S., Jurkeviciute, G., He, J.-Z., Auburger, J., Schmitt, J., Kramer, G., Bukau, B., Enchev, R. I., Balchin, D.
10.1101/2025.05.27.656346 — Posted: 2025-05-30

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