Channel:  The Howard Hughes Medical Institute (HHMI)

2,396 Articles

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Transforming chemigenetic bimolecular fluorescence complementation systems into chemical dimerizers using chemistry
Kumar, P., Gutu, A., Waring, A., Brown, T. A., Lavis, L. D., Tebo, A. G.
10.1101/2023.12.30.573644 — Posted: 2024-01-01
A cell type-aware framework for nominating non-coding variants in Mendelian regulatory disorders
Lee, A. S., Ayers, L. J., Kosicki, M., Chan, W.-M., Fozo, L. N., Pratt, B. M., Collins, T. E., Zhao, B., Rose, M. F., Sanchis-Juan, A., Fu, J. M., Wong, I., Zhao, X., Tenney, A. P., Lee, C., Laricchia, K. M., Barry, B. J., Bradford, V. R., Lek, M., MacArthur, D. G., Lee, E. A., Talkowski, M. E., Brand, H., Pennacchio, L. A., Engle, E. C.
10.1101/2023.12.22.23300468 — Posted: 2023-12-27
Genome evolution is surprisingly predictable after initial hybridization
Langdon, Q. K., Groh, J. S., Aguillon, S., Powell, D. L., Gunn, T. R., Payne, C. Y., Baczenas, J. J., Donny, A., Dodge, T. O., Du, K., Schartl, M., Rios-Cardenas, O., Gutierrez-Rodriguez, C., Morris, M., Schumer, M.
10.1101/2023.12.21.572897 — Posted: 2023-12-23
PEARL-catalyzed peptide bond formation after chain reversal during the biosynthesis of non-ribosomal peptides
Yu, Y., van der Donk, W.
10.1101/2023.12.23.573212 — Posted: 2023-12-23
Atomic context-conditioned protein sequence design using LigandMPNN
Dauparas, J., Lee, G. R., Pecoraro, R., An, L., Anishchenko, I., Glasscock, C., Baker, D.
10.1101/2023.12.22.573103 — Posted: 2023-12-23
De novo design of diverse small molecule binders and sensors using Shape Complementary Pseudocycles
An, L., Said, M., Tran, L., Majumder, S., Goreshnik, I., Lee, G. R., Juergens, D., Dauparas, J., Anishchenko, I., Coventry, B., Bera, A. K., Kang, A., Levine, P. M., Alvarez, V., Pillai, A., Norn, C., Feldman, D., Zorine, D., Hicks, D. R., Li, X., Sanchez, M. G., Vafeados, D. K., Salveson, P. J., Vorobieva, A. A., Baker, D.
10.1101/2023.12.20.572602 — Posted: 2023-12-21
Identification of a short, single site matriglycan that maintains neuromuscular function in the mouse
Yang, T., Chandel, I., Gonzales, M., Okuma, H., Prouty, S. J., Zarei, S., Joseph, S., Garringer, K. W., Ocampo Landa, S., Yonekawa, T., Walimbe, A. S., Venzke, D. P., Anderson, M. E., Hord, J. M., Campbell, K. P.
10.1101/2023.12.20.572361 — Posted: 2023-12-21
Carcinogenesis is associated with sex-biased tissue environments and imbalances between estrogen receptor alpha and thyroid hormone receptors
Zhang, F., Deng, M.
10.1101/2023.05.20.541565 — Posted: 2023-12-21
A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines
Lee, J., Stewart, C., Schaefer, A., Leaf, E. M., Park, Y.-J., Asarnow, D., Powers, J. M., Treichel, C., Corti, D., Baric, R., King, N. P., Veesler, D.
10.1101/2023.12.12.571160 — Posted: 2023-12-20
Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation
Li, H., Ji, Z., Paulo, J. A., Gygi, S. P., Rapoport, T. A.
10.1101/2023.12.20.572403 — Posted: 2023-12-20

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