Channel:  The Howard Hughes Medical Institute (HHMI)

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JUNIPER: Reconstructing Transmission Events from Next-Generation Sequencing Data at Scale
Specht, I., Moreno, G. K., Brock-Fisher, T., Krasilnikova, L. A., Petros, B. A., Pekar, J. E., Schifferli, M., Fry, B., Brown, C. M., Madoff, L. C., Burns, M., Schaffner, S., Park, D. J., MacInnis, B. L., Ozonoff, A., Varilly, P., Mitzenmacher, M. D., Sabeti, P. C.
10.1101/2025.03.02.25323192 — Posted: 2025-03-05
Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy
Dong, G., Ma, C. C., Mao, S., Naik, S. M., Brown, K. S.-M., McDonough, G. A., Kim, J., Kirkham, S. L., Cherry, J., Uretsky, M., Spurlock, E., McKee, A., Huang, A. Y., Miller, M. B., Lee, E. A., Walsh, C. A.
10.1101/2025.03.03.641217 — Posted: 2025-03-04
Prdm16-dependent antigen-presenting cells induce tolerance to intestinal antigens
Fu, L., Upadhyay, R., Pokrovskii, M., Chen, F. M., Romero-Meza, G., Griesemer, A., Littman, D. R.
10.1101/2024.07.23.604803 — Posted: 2025-03-03
Transcriptional complexity in the insect central complex: single nuclei RNA sequencing of adult brain neurons derived from type 2 neuroblasts
Epiney, D., Chaya, G. M., Dillon, N., Lai, S.-L., Doe, C.
10.1101/2023.12.10.571022 — Posted: 2025-03-03
A theory of rapid behavioral inferences under the pressure of time
Hermundstad, A. M., Młynarski, W. F.
10.1101/2024.08.26.609738 — Posted: 2025-03-03
Deep learning guided design of protease substrates
Martin Alonso, M. C., Alamdari, S., Samad, T. S., Yang, K. K., Bhatia, S. N., Amini, A. P.
10.1101/2025.02.27.640681 — Posted: 2025-03-02
DNA origami vaccines program antigen-focused germinal centers
Romanov, A., Knappe, G. A., Ronsard, L., Suh, H., Omer, M., Chapman, A. P., Lewis, V., Spivakovsky, K., Canales, J., Reizis, B., Tingle, R., Cottrell, C., Schiffner, T., Lingwood, D., Bathe, M., Irvine, D. J.
10.1101/2025.02.21.639354 — Posted: 2025-03-01
Atomically accurate de novo design of antibodies with RFdiffusion
Bennett, N. R., Watson, J. L., Ragotte, R. J., Borst, A. J., See, D. L., Weidle, C., Biswas, R., Yu, Y., Shrock, E. L., Ault, R., Leung, P. J. Y., Huang, B., Goreshnik, I., Tam, J., Carr, K. D., Singer, B., Criswell, C., Wicky, B. I. M., Vafeados, D., Garcia Sanchez, M., Kim, H. M., Vazquez Torres, S., Chan, S., Sun, S. M., Spear, T., Sun, Y., OReilly, K., Maris, J. M., Sgourakis, N. G., Melnyk, R. A., Liu, C. C., Baker, D.
10.1101/2024.03.14.585103 — Posted: 2025-02-28
Molecular grammars of intrinsically disordered regions that span the human proteome
Ruff, K. M., King, M. R., Ying, A. W., Liu, V., Pant, A., Lieberman, W. E., Shinn, M. K., su, x., Kadoch, C., Pappu, R. V.
10.1101/2025.02.27.640591 — Posted: 2025-02-28
Massively parallel assessment of designed protein solution properties using mass spectrometry and peptide barcoding
Feldman, D., Sims, J. N., Li, X., Johnson, R., Gerben, S., Kim, D. E., Richardson, C., Koepnik, B., Eisenach, H., Hicks, D. R., Yang, E., Wicky, B. I. M., Milles, L. F., Bera, A., Brackenbrough, E., Joyce, E., Sankaran, B., Lubner, J. M., Goreshnik, I., Vafeados, D., Allen, A., Stewart, L., MacCoss, M. J., Baker, D.
10.1101/2025.02.24.639402 — Posted: 2025-02-28

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