Channel:  Impact of Genomic Variation on Function (IGVF)

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

46 Articles

A framework for summarizing chromatin state annotations within and identifying differential annotations across groups of samples
Vu, H. T., Koch, Z., Fiziev, P., Ernst, J.
10.1101/2022.05.08.491094 — Posted: 2022-05-08
Limited overlap of eQTLs and GWAS hits due to systematic differences in discovery
Mostafavi, H., Spence, J. P., Naqvi, S., Pritchard, J. K.
10.1101/2022.05.07.491045 — Posted: 2022-05-08
A unique epigenomic landscape defines CD8+ tissue-resident memory T cells
Buquicchio, F. A., Fonseca, R., Belk, J. A., Evrard, M., Obers, A., Qi, Y., Daniel, B., Yost, K. E., Satpathy, A. T., Mackay, L. K.
10.1101/2022.05.04.490680 — Posted: 2022-05-06
Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2
Schmidt, H., Zhang, M., Mourelatos, H., Sanchez-Rivera, F. J., Lowe, S. W., Ventura, A., Leslie, C. S., Pritykin, Y.
10.1101/2022.05.02.490368 — Posted: 2022-05-03
Microbiota-instructed regulatory T cell differentiation is mediated by a distinct RORγt+ antigen presenting cell subset
Kedmi, R., Najar, T., Mesa, K. R., Grayson, A., Kroehling, L., Hao, Y., Hao, S., Pokrovskii, M., Xu, M., Talbot, J., Wang, J., Germino, J., Lareau, C. A., Satpathy, A. T., Anderson, M. S., Laufer, T. M., Aifantis, I., Bartleson, J. M., Allen, P. M., Paidassi, H., Gardner, J. M., Stoeckius, M., Littman, D. R.
10.1101/2021.11.19.469318 — Posted: 2022-04-29
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
Belk, J., Yao, W., Ly, N., Freitas, K., Chen, Y.-T., Shi, Q., Valencia, A., Shifrut, E., Kale, N., Yost, K., Duffy, C., Hwee, M., Miao, Z., Ashworth, A., Mackall, C., Marson, A., Carnevale, J., Vardhana, S., Satpathy, A.
10.1101/2022.04.20.488974 — Posted: 2022-04-21
A flexible modeling and inference framework for estimating variant effect sizes from GWAS summary statistics
Spence, J. P., Sinnott-Armstrong, N., Assimes, T., Pritchard, J. K.
10.1101/2022.04.18.488696 — Posted: 2022-04-19
Evidence-based calibration of computational tools for missense variant pathogenicity classification and ClinGen recommendations for clinical use of PP3/BP4 criteria
Pejaver, V., Byrne, A. B., Feng, B.-J., Pagel, K. A., Mooney, S. D., Karchin, R., O'Donnell-Luria, A., Harrison, S. M., Tavtigian, S. V., Greenblatt, M. S., Biesecker, L. G., Radivojac, P., Brenner, S. E., ClinGen Sequence Variant Interpretation Working Group
10.1101/2022.03.17.484479 — Posted: 2022-03-19
Evolution of transposable element-derived enhancer activity
Du, A. Y., Zhuo, X., Sundaram, V., Jensen, N. O., Chaudhari, H. G., Saccone, N. L., Cohen, B. A., Wang, T.
10.1101/2022.03.16.483999 — Posted: 2022-03-17
Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data
Zhang, M. J., Hou, K., Dey, K. K., Sakaue, S., Jagadeesh, K. A., Weinand, K., Taychameekiatchai, A., Rao, P., Pisco, A. O., Zou, J., Wang, B., Gandal, M., Raychaudhuri, S., Pasaniuc, B., Price, A. L.
10.1101/2021.09.24.461597 — Posted: 2022-03-04

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