Channel:  Impact of Genomic Variation on Function (IGVF)

232 Articles

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Inherent instability of simple DNA repeats shapes an evolutionarily stable distribution of repeat lengths
McGinty, R. J., Balick, D. J., Mirkin, S. M., Sunyaev, S. R.
10.1101/2025.01.09.631797 — Posted: 2025-10-09
Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy
Blaisdell, A., Bachl, S., Sandoval, L. R., Ching, C., Bowman, C. J., Kale, N., Prabandham, M., Diolaiti, M., Havig, C., Advincula, R., Lenci, N., Li, Z., Yamashita, E., Wang, C. H., Zhang, S., Liu, Q., Achacoso, P., Stibor, D., Oynebraten, I., Seo, J., Ashworth, A., Marson, A., Ye, C. J., Malynn, B. A., Eyquem, J., Carnevale, J., Ma, A.
10.1101/2025.10.05.680562 — Posted: 2025-10-06
Gradient-aware modeling advances AI-driven prediction of genetic perturbation effects
Jerby, L., Zhu, D.
10.1101/2025.10.03.680360 — Posted: 2025-10-05
Segregating DNA lesions point to high selective advantage of tumor initiating cells
Seplyarskiy, V., Shady, M., Andrianova, M. A., Chapman, M. S., Van Allen, E., Sunyaev, S. R.
10.1101/2025.10.02.680094 — Posted: 2025-10-04
Uniform processing and analysis of IGVF massively parallel reporter assay data with MPRAsnakeflow
Rosen, J. D., Vasanthakumari, A. D., Salomon, K., de Lange, N., Dash, P. M., Keukeleire, P., Hassan, A., Barrera, A., Kircher, M., Love, M. I., Schubach, M.
10.1101/2025.09.25.678548 — Posted: 2025-09-29
Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases
Koh, B., Gal Oz, S. T., Sato, R., Nguyen, H., Dunlap, G. S., Mahony, C., Bolton, C., Wedderburn, L. R., Croft, A., Donlin, L., Raychaudhuri, S., Korsunskiy, I., Rao, D. A., Brenner, M. B.
10.1101/2025.09.23.677874 — Posted: 2025-09-25
Sensitive, direct detection of non-coding off-target base editor unwinding and editing in primary cells
Wang, T., Jessa, S., Marinov, G. K., Klemm, S., Kundaje, A., Greenleaf, W. J.
10.1101/2025.09.25.678665 — Posted: 2025-09-25
Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues
Salla, M., Obermayer, B., Cotta, M., Friebel, E., Campo-Garcia, J., Charalambous, G., Bueno, R. J., Lieu, D., Dabek, P., Helmuth, A., Tellides, G., Assi, R., Bankov, K., Lodrini, M., Deubzer, H., Chung, H., Beule, D., Radbruch, H., Capper, D., Heppner, F., Starossom, S. C., Lareau, C., Liu, I., Ludwig, L. S.
10.1101/2025.09.17.675534 — Posted: 2025-09-20
An unbiased survey of distal element-gene regulatory interactions with direct-capture targeted Perturb-seq
Ray, J., Jagoda, E., Sheth, M. U., Galante, J., Amgalan, D., Gschwind, A. R., Munger, C. J., Huang, J., Munson, G., Murphy, M., Mattei, E., Barry, T., Singh, V., Baskaran, A., Kang, H., Katsevich, E., Steinmetz, L. M., Engreitz, J.
10.1101/2025.09.16.676677 — Posted: 2025-09-17
Shared and distinct sequence-function signatures define different modes of human TpoR activation
Wu, X., McLeod, H., Malinovitch, A., Hunter, S., Ramesh, S., Go, M., Nguyen, J. V., Rubin, A. F., Burger, W. A., Blombery, P., Call, M. E., Call, M. J.
10.1101/2025.09.09.675271 — Posted: 2025-09-13

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