Channel:  Impact of Genomic Variation on Function (IGVF)

232 Articles

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Comparing bulk and single-cell methodologies and models to profile gene expression, chromatin accessibility and regulatory links in endothelial cells treated with TNFα
Zevounou, J., Lo, K. S., McGinnis, C. S., Satpathy, A. T., Lettre, G.
10.64898/2026.03.13.711357 — Posted: 2026-03-16
Genome-scale mapping of variant, enhancer and gene function in primary human CD4+ T cells
Moonen, D. P., Claringbould, A., Gschwind, A. R., Schrod, S., Braunger, J., Feng, C., Rauscher, B., Yi, J., Bi, S. Z., Matthess, Y., Kaulich, M., Acob, R. A., Ayer, A., Engreitz, J. M., Velten, B., Stegle, O., Trynka, G., Zaugg, J. B., Schraivogel, D., Steinmetz, L. M.
10.64898/2026.03.09.710372 — Posted: 2026-03-11
Reprogramming of neuronal genome function and phenotype by astrocytes
Li, B., Hagy, K., Safi, A., Beer, M. A., Barrera, A., Geraghty, S., Rai, R., Pederson, A. N., Reisman, S. J., Love, M. I., Sullivan, P. F., Eroglu, C., Crawford, G. E., Gersbach, C. A.
10.64898/2026.03.07.710282 — Posted: 2026-03-07
Single-Cell Genomics Decontamination with CellSweep
Caskey, M., Rich, J., Weber, R., Mortazavi, A., Pachter, L., Hallgrimsdottir, I. B.
10.64898/2026.03.04.709349 — Posted: 2026-03-06
Massive-scale single-nucleus multi-omics identifies novel rare noncoding drivers of Parkinson's disease
Menon, S., Turner, A. W., Chang, S. H., Johnson, A. W., Chang, H. H., Shah, A. J., Zeng, Y., Strohlein, C. E., Kampman, L., Colston, C., Kozlenkov, A., Dracheva, S., Avenali, M., Palermo, G., Ceravolo, R., Valente, E. M., Gabbert, C., Trinh, J., Serrano, G. E., Beach, T. G., Global Parkinson's Genetic Program (GP2), , Shulman, J. M., Blauwendraat, C., Montine, T. J., Fang, Z.-H., Belloy, M. E., Corces, M. R.
10.64898/2026.03.05.709922 — Posted: 2026-03-05
A scalable approach to resolving variants of uncertain significance
Tejura, M., Chen, Y., McEwen, A. E., Stewart, R., Sverchkov, Y., Laval, F., Woo, I., Zeiberg, D., Shen, R., Fayer, S., Stone, J., Smith, N., Casadei, S., Wang, Z. R., Snyder, M., Capodanno, B. J., Gupta, P., Benazouz, M., Jain, S., Heidl, S., Muffley, L., Dong, S., Lin, K., Hitz, B. C., Gabdank, I., Da, E. Y., Best, S., Grindstaff, S., Reinhart, D., Rodriguez-Salas, L., Seid, O., Vandi, A. J., Wenman, C., Wheelock, M. K., Pendyala, S., Holmes, D., Xu, A., Hosokai, A., Tixhon, M., Reno, C., Ewald, J. D., Spirohn-Fitzgerald, K., Teelucksingh, T., Hao, T., Chen, Z. S., Haghighi, M., Hamid, A. K.
10.64898/2026.02.14.705848 — Posted: 2026-02-23
Estimating cis and trans contributions todifferences in gene regulation
Hallgrimsdottir, I. B., Carilli, M., Pachter, L.
10.1101/2024.07.13.603403 — Posted: 2026-02-18
Ancestry-specific performance of variant effect predictors in clinical variant classification
Hoffing, R., Zeiberg, D., Stenton, S. L., Mort, M., Cooper, D. N., Hahn, M. W., O'Donnell-Luria, A., Ward, L. D., Radivojac, P.
10.64898/2026.02.14.705914 — Posted: 2026-02-17
Gene-based calibration of high-throughput functional assays for clinical variant classification
Zeiberg, D., Stewart, R. C., Jain, S., Tejura, M., McEwen, A. E., Fayer, S., Sverchkov, Y., Craven, M., Pejaver, V., Rubin, A. F., Starita, L. M., Fowler, D. M., O'Donnell-Luria, A., Radivojac, P.
10.1101/2025.04.29.651326 — Posted: 2026-02-16
Predicting interaction-specific protein-protein interaction perturbations by missense variants with MutPred-PPI
Stewart, R., Laval, F., Coppin, G., Spirohn-Fitzgerald, K., Tixhon, M., Hao, T., Calderwood, M. A., Mort, M., Cooper, D. N., Vidal, M., Radivojac, P.
10.64898/2025.12.20.695738 — Posted: 2026-02-12

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