Channel:  The Michael J. Fox Foundation

187 Articles

Fast purification of recombinant monomeric amyloid-β from E. coli and amyloid-β-mCherry aggregates from mammalian cells
Stephens, A. D., Lu, M., Kaminski Schierle, G. S.
10.1101/2020.05.13.093534 — Posted: 2020-05-15
Purification of recombinant α-Synuclein: a comparison of commonly used protocols
Stephens, A. D., Matak-Vinkovic, D., Kaminski Schierle, G. S.
10.1101/2020.05.13.093286 — Posted: 2020-05-15
Protection from α-synuclein-induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20 in the rat midbrain
De Miranda, B. R., Rocha, E. M., Castro, S., Greenamyre, J. T.
10.1101/2020.05.11.089078 — Posted: 2020-05-13
Large-scale pathway-specific polygenic risk, transcriptomic community networks and functional inferences in Parkinson disease
Bandres-Ciga, S., Saez-Atienzar, S., Kim, J. J., Makarious, M., Faghri, F., Diez-Fairen, M., Iwaki, H., Leonard, H., Botia, J. A., Ryten, M., Hernandez, D., Gibbs, R., Ding, J., Gan-Or, Z., Noyce, A., Pihlstrom, L., Torkamani, A., Scholz, S. W., Traynor, B., Ehrlich, D., Scherzer, C. R., Bookman, M., Cookson, M. R., Blauwendraat, C., Nalls, M. A., Singleton, A., International Parkinson's Disease Genomics Consortium
10.1101/2020.05.05.079228 — Posted: 2020-05-06
Parkinson Disease-Linked Parkin Mediates Redox Reactions That Lower Oxidative Stress In Mammalian Brain
El Kodsi, D. N., Tokarew, J. M., Sengupta, R., Lengacher, N. A., Ng, A. C., Boston, H., Jiang, Q., Palmberg, C., Pileggi, C., Shutinoski, B., Li, J., Nguyen, A. P., Fehr, T. K., Im, D. S., Callaghan, S., Park, D. S., LaVoie, M. J., Chan, J. A., Takanashi, M., Hattori, N., Ratan, R. R., Zecca, L., Puente, L., Shaw, G. S., Harper, M.-E., Holmgren, A., Tomlinson, J. J., Schlossmacher, M. G.
10.1101/2020.04.26.062380 — Posted: 2020-05-03
Protein synthesis is suppressed in sporadic and familial Parkinson's Disease by LRRK2
Deshpande, P., Flinkman, D., Hong, Y., Goltseva, E., Siino, V., Sun, L., Peltonen, S., Elo, L., Kaasinen, V., James, P., Coffey, E. T.
10.1101/2020.04.27.053694 — Posted: 2020-04-28
LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade
Yanatori, I., Dhekne, H. S., Vides, E. G., Sobu, Y., Diez, F., Pfeffer, S. R.
10.1101/2020.04.28.065664 — Posted: 2020-04-28
A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
Rusilowicz-Jones, E., Jardine, J., Kallinos, A., Pinto-Fernandez, A., Guenther, F., Giurrandino, M., Barone, F. G., McCarron, K., Burke, C. J., Murad, A., Martinez, A., Marcassa, E., Gersch, M., Buckmelter, A., Kayser-Bricker, K., Lamoliatte, F., Gajbhiye, A., Davis, S., Scott, H. C., Murphy, E., England, K., Mortiboys, H., Komander, D., Trost, M., Kessler, B. M., Ioannidis, S., Ahlijanian, M., Urbe, S., Clague, M. J.
10.1101/2020.04.16.044206 — Posted: 2020-04-20
Control of mammalian brain aging by the unfolded protein response (UPR)
Cabral Miranda, F., Tamburini, G., Martinez, G., Medinas, D., Gerakis, Y., Miedema, T., Duran-Aniotz, C., Ardilles, A., Ibaceta, C., Sabusap, C., Bermedo-Garcia, F., Adamson, S., Vitangcol, K., Huerta, H., Zhang, X., Nakamura, T., Sardi, P., Lipton, S., Kennedy, B., Cardenas, J. C., Palacios, A., Plate, L., Henriquez, J. P., Hetz, C.
10.1101/2020.04.13.039172 — Posted: 2020-04-14
Pathogenic LRRK2 regulates ciliation probability upstream of Tau Tubulin kinase 2
Sobu, Y., Wawro, P. S., Dhekne, H. S., Pfeffer, S. R.
10.1101/2020.04.07.029983 — Posted: 2020-04-08

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