Channel:  The Michael J. Fox Foundation

187 Articles

LRRK2 regulates innate immune responses and neuroinflammation during Mycobacterium tuberculosis infection
Weindel, C. G., Bell, S. L., Huntington, T. E., Vail, K. J., Srinivasan, R., Patrick, K. L., Watson, R. O.
10.1101/699066 — Posted: 2019-07-26
ThX - A next-generation probe for the early detection of amyloid aggregates
Needham, L.-M., Weber, J., Varela, J. A., Fyfe, J. W. B., Do, D. T., Xu, C. K., Keenlyside, B., Cliffe, R., Klenerman, D., Dobson, C. M., Hunter, C. A., Bohndiek, S. E., Snaddon, T. N., Lee, S. F.
10.1101/713594 — Posted: 2019-07-24
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
Berndsen, K., Lis, P., Yeshaw, W., Wawro, P. S., Nirujogi, R. S., Wightman, M., Macartney, T., Dorward, M., Knebel, A., Tonelli, F., Pfeffer, S. R., Alessi, D. R.
10.1101/711176 — Posted: 2019-07-22
Bach2 is a potent repressor of Nrf2-mediated antioxidant enzyme expression in dopaminergic neurons
Waxman, E. A.
10.1101/687590 — Posted: 2019-07-02
CSF sTREM2 correlates with CSF tau in advancing Parkinson’s disease
Wilson, E. N., Swarovski, M. S., Linortner, P., Shahid, M., Zuckerman, A. J., Wang, Q., Channappa, D., Minhas, P. S., Mhatre, S. D., Plowey, E. D., Quinn, J. F., Zabetian, C. P., Tian, L., Longo, F. M., Cholerton, B., Montine, T. J., Poston, K. L., Andreasson, K. I.
10.1101/687269 — Posted: 2019-06-30
Organotypic slice culture model demonstrates interneuronal spreading of alpha-synuclein aggregates
Elfarrash, S., Jensen, N. M., Ferreira, N., Betzer, C., Thevathasan, J. V., Diekmann, R., Adel, M., Omar, N. M., Boraie, M., Gad, S., Ries, J., Kirik, D., Nabavi, S., Jensen, P. H.
10.1101/681064 — Posted: 2019-06-24
A revised 1.6 Å structure of the GTPase domain of the Parkinson’s disease-associated protein LRRK2 provides insights into mechanisms
Wu, C.-X., Liao, J., Park, Y., Hoang, N. C., Engel, V. A., Wan, L., Oh, M., Sanishvili, R., Takagi, Y., Johnson, S. M., Wang, M., Federici, M., Nichols, R. J., Bellina, A., Reed, X., Cookson, M. R., Hoang, Q. Q.
10.1101/676627 — Posted: 2019-06-23
Phosphorylation of Ser111 in Rab8a modulates Rabin8 dependent activation by perturbation of side chain interaction networks
Pourjafar-Dehkordi, D., Vieweg, S., Itzen, A., Zacharias, M.
10.1101/670729 — Posted: 2019-06-13
The Emerging Gait Dysfunction Phenotype in Idiopathic Parkinson’s Disease
Skidmore, F., Monroe, W., Hurt, C., Nicholas, A., Gerstenecker, A., Anthony, T., Jololian, L., Cutter, G., Bashir, A., Denney, T., Standaert, D., Disbrow, E.
10.1101/632638 — Posted: 2019-05-17
Integration of eQTL and Parkinson’s disease GWAS data implicates 11 disease genes
Kia, D. A., Zhang, D., Guelfi, S., Manzoni, C., Hubbard, L., United Kingdom Brain Expression Consortium (UKBEC), , International PD Genomics Consortium (IPDGC), , Reynolds, R. H., Botia, J. A., Ryten, M., Ferrari, R., Lewis, P. A., Williams, N., Trabzuni, D., Hardy, J., Wood, N. W.
10.1101/627216 — Posted: 2019-05-05

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