Channel:  The Michael J. Fox Foundation

187 Articles

Catechol-Containing Compounds are a Broad Class of Amyloid Inhibitors: Redox State is a Key Determinant of the Inhibitory Activities
Velander, P., Wu, L., Hildreth, S. B., Vogelaar, N. J., Mukhopadhyay, B., Zhang, S., Helm, R. F., Xu, B.
10.1101/2020.10.08.873620 — Posted: 2020-10-13
Discovery of the first selective M4 muscarinic acetylcholine receptor antagonists with in vivo anti-parkinsonian and anti-dystonic efficacy
Moehle, M. S., Bender, A. M., Dickerson, J. W., Foster, D. J., Donsante, Y., Peng, W., Bryany, Z. K., Bridges, T. M., Chang, S., Watson, K. J., O'Neill, J. C., Engers, J. L., Peng, L., Rodriguez, A., Niswender, C. M., Lindsley, C. W., Conn, P. J., Rook, J. M.
10.1101/2020.10.12.324152 — Posted: 2020-10-12
Endogenous Rab29 does not impact basal or nigericin and monensin stimulated LRRK2 pathway activity
Kalogeropulou, A. F., Freemantle, J. B., Lis, P., Vides, E. G., Polinski, N. K., Alessi, D. R.
10.1101/2020.06.08.139675 — Posted: 2020-10-07
Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology: How specific are the conformation-specific α-synuclein antibodies?
Kumar, S. T., Jagannath, S., Francois, C., Vanderstichele, H., Stoops, E., Lashuel, H. A.
10.1101/2020.06.15.151514 — Posted: 2020-09-01
A robust and versatile nanobody platform for drug delivery
Shen, Z., Xiang, Y., Vergara, S., Chen, A., Xiao, Z., Santiago, U., Jin, C., Sang, Z., Luo, J., Chen, K., Schneidman-Duhovny, D., Camacho, C. J., Calero, G., Hu, B., Shi, Y.
10.1101/2020.08.19.257725 — Posted: 2020-08-20
Urinary proteome profiling for stratifying patients with familial Parkinsons disease
Virreira Winter, S., Karayel, O., Strauss, M. T., Padmanabhan, S., Surface, M., Merchant, K., Alcalay, R. N., Mann, M.
10.1101/2020.08.09.243584 — Posted: 2020-08-10
Pathogenic LRRK2 R1441C mutation is associated with striatal alterations
Xenias, H., Chen, C., Kang, S., Cherian, S., Situ, X., Shanmugasundaram, B., Scesa, G., Chan, C. S., Parisiadou, L.
10.1101/2020.03.11.986455 — Posted: 2020-07-29
Modeling Alpha-Synuclein Pathology in a Human Brain-Chip to Assess Blood-Brain Barrier Disruption in Parkinson's Disease
Pediaditakis, I., Kodella, K. R., Manatakis, D. V., Hinojosa, C. D., Manolakos, E. S., Rubin, L. L., Hamilton, G. A., Karalis, K.
10.1101/2020.07.22.207340 — Posted: 2020-07-27
Discordant transcriptional signatures of mitochondrial genes in Parkinson's disease human myeloid cells
Navarro, E., Udine, E., de Paiva Lopes, K., Parks, M., Riboldi, G., Schilder, B. M., Humphrey, J., Snijders, G. J. L., Vialle, R. A., Zhuang, M., Sikder, T., Argyrou, C., Allan, A., Chao, M., Farrell, K., Henderson, B., Simon, S., Raymond, D., Elango, S., Ortega, R. A., Shanker, V., Swan, M., Zhu, C., Ramdhani, R., Walker, R. H., Tse, W., Sano, M., Pereira, A. C., Ahfeldt, T., Goate, A. M., Bressman, S., Crary, J. F., de Witte, L., Frucht, S., Saunders-Pullman, R., Raj, T.
10.1101/2020.07.20.212407 — Posted: 2020-07-22
Associations of Mitochondrial Genomic Variation with Corticobasal Degeneration, Progressive Supranuclear Palsy, and Neuropathological Tau Measures
Rebecca R Valentino, Nikoleta Tamvaka, Michael G Heckman, Patrick W Johnson, Alexandra I Soto-Beasley, Ronald L Walton, Shunsuke Koga, Ryan J Uitti, Zbigniew K Wszolek, Dennis W Dickson, Owen A Ross
10.1101/2020.07.10.196097 — Posted: 2020-07-11

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