Channel:  The Michael J. Fox Foundation

187 Articles

Association of a common genetic variant with Parkinson's disease is propagated through microglia
Langston, R., Beilina, A., Reed, X., Singleton, A., Blauwendraat, C., Gibbs, J. R., Cookson, M. R.
10.1101/2021.01.15.426824 — Posted: 2021-01-17
The role of water mobility in protein misfolding
Stephens, A. D., Kolbel, J., Moons, R., Ruggerio, M. T., Mahmoudi, N., Shmool, T. A., McCoy, T. M., Nietlispach, D., Routh, A. F., Sobott, F., Zeitler, J. A., Kaminski Schierle, G. S.
10.1101/2021.01.06.425575 — Posted: 2021-01-09
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
Malik, A. U., Karapetsas, A., Nirujogi, R. S., Mathea, S., Pal, P., Lis, P., Taylor, M., Purlyte, E., Gourlay, R., Dorward, M., Weidlich, S., Toth, R., Polinski, N. K., Knapp, S., Tonelli, F., Alessi, D. R.
10.1101/2020.11.25.397836 — Posted: 2020-11-26
Development of a multiplexed targeted mass spectrometry assay for LRRK2 phosphorylated Rabs and Ser910/Ser935 biomarker sites
Nirujogi, R. S., Tonelli, F., Taylor, M., Lis, P., Zimprich, A., Sammler, E., Alessi, D. R.
10.1101/2020.11.23.394486 — Posted: 2020-11-23
Age-Associated Insolubility of Parkin in Human Midbrain is Linked to Redox Balance and Sequestration of Reactive Dopamine Metabolites
Tokarew, J. M., El Kodsi, D. N., Lengacher, N. A., Fehr, T. K., Nguyen, A. P., Shutinoski, B., O'Nuallain, B., Jin, M., Khan, J., Ng, A. C. H., Li, J., Jiang, Q., Zhang, M., Wang, L., Sengupta, R., Barber, K., Tran, A., Zandee, S., Dong, X., Scherzer, C. R., Prat, A., Tsai, E., Takanashi, M., Hattori, N., Chan, J. A., Zecca, L., West, A., Holmgren, A., Puente, L., Shaw, G. S., Toth, G., Woulfe, J., Taylor, P., Tomlinson, J. J., Schlossmacher, M. G.
10.1101/2020.11.20.392175 — Posted: 2020-11-21
Bioinformatic and computational analysis reveals the prevalence and nature of PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases
Hatstat, A. K., Pupi, M. D., McCafferty, D. G.
10.1101/2020.11.12.380584 — Posted: 2020-11-14
The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease
Castro, S. L., Rocha, E. M., Bodle, C. R., Johnson, K. E., Greenamyre, J. T., De Miranda, B. R.
10.1101/2020.11.02.365775 — Posted: 2020-11-06
echolocatoR: an automated end-to-end statistical and functional genomic fine-mapping pipeline
Schilder, B. M., Humphrey, J., Raj, T.
10.1101/2020.10.22.351221 — Posted: 2020-10-23
Fine-mapping of Parkinson's disease susceptibility loci identifies putative causal variants
Schilder, B. M., Raj, T.
10.1101/2020.10.22.340158 — Posted: 2020-10-22
Tau pathology spreads between anatomically-connected regions of the brain and is modulated by a LRRK2 mutation
Henderson, M., Cornblath, E. J., Li, H. L., Changolkar, L., Zhang, B., Brown, H. J., Gathagan, R. J., Olufemi, M. F., Bassett, D. S., Trojanowski, J. Q., Lee, V. M. Y.
10.1101/2020.10.13.337857 — Posted: 2020-10-14

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