Channel:  The Michael J. Fox Foundation

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

187 Articles

Fine-mapping of SNCA in REM sleep behavior disorder and overt synucleinopathies
Krohn, L. M., Wu, R. Y., Heilbron, K., Ruskey, J. A., Laurent, S. B., Blauwendraat, C., Alam, A., Arnulf, I., Hu, M. T., Dauvilliers, Y., Högl, B., Toft, M., Bjornara, K. A., Stefani, A., Holzknecht, E., Monaca, C. C., Beatriz, A., Plazzi, G., Antelmi, E., Ferini-Strambi, L., Young, P., Heidbreder, A., Cochen De Cock, V., Mollenhauer, B., Sixel-Döring, F., Trenkwalder, C., Sonka, K., Kemlink, D., Figorilli, M., Puligheddu, M., Dijkstra, F., Viaene, M., Oertel, W., Toffoli, M., Gigli, G. L., Valente, M., Gagnon, J.-F., Nalls, M. A., Singleton, A. B., 23andMe Research Team, , Desautels, A., M
10.1101/756528 — Posted: 2019-09-04
PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72
Vieweg, S., Mulholland, K., Braeuning, B., Kachariya, N., Lai, Y.-C., Toth, R., Sattler, M., Groll, M., Itzen, A., Muqit, M.
10.1101/764019 — Posted: 2019-09-12
Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinsons disease
Whiffin, N., Armean, I. M., Kleinman, A., Marshall, J. L., Minikel, E. V., Goodrich, J. K., Quaife, N. M., Cole, J. B., Wang, Q., Karczewski, K. J., Cummings, B. B., Francioli, L., Laricchia, K., Guan, A., Alipanahi, B., Morrison, P., Baptista, M. A., Merchant, K. M., Genome Aggregation Database Production Team, , Genome Aggregation Database Consortium, , Ware, J. S., Havulinna, A. S., Iliadou, B., Lee, J.-J., Nadkarni, G. N., Whiteman, C., the 23andMe Research Team, , Daly, M., Esko, T., Hultman, C., Loos, R. J., Milani, L., Palotie, A., Pato, C., Pato, M., Saleheen, D., Sullivan, P. F., A
10.1101/561472 — Posted: 2019-09-18
A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oligomers and fibrils: towards improving experimental reproducibility in α-synuclein research
Kumar, S. T., Donzelli, S., Chiki, A., Syed, M. M. K., Lashuel, H.
10.1101/772160 — Posted: 2019-09-21
Analysis of common and rare VPS13C variants in late onset Parkinson disease
Rudakou, U., Ruskey, J. A., Krohn, L., Laurent, S. B., Spiegelman, D., Greenbaum, L., Yahalom, G., Desautels, A., Montplaisir, J. Y. Y., Fahn, S., Waters, C. H., Levy, O., Kehoe, C. M., Narayan, S., Dauvilliers, Y., Dupre, N., Hassin-Baer, S., Alcalay, R. N., Rouleau, G. A., Fon, E. A., Gan-Or, Z.
10.1101/705533 — Posted: 2019-09-22
Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson’s Disease
Sellnow, R. C., Steece-Collier, K., Altwal, F., Sandoval, I. M., Kordower, J. H., Collier, T. J., Sortwell, C. E., West, A. R., Manfredsson, F.
10.1101/768374 — Posted: 2019-09-28
No genetic evidence for involvement of alcohol dehydrogenase genes in risk for Parkinson’s disease
Kim, J. J., Bandres Ciga, S., Blauwendraat, C., International Parkinson's Disease Genomics Consortium, , Gan-Or, Z.
10.1101/784405 — Posted: 2019-10-03
Accurate MS-based Rab10 phosphorylation stoichiometry determination as readout for LRRK2 activity in Parkinson’s disease
Karayel, O., Tonelli, F., Virreira Winter, S., Geyer, P. E., Fan, Y., Sammler, E. M., Alessi, D. R., Steger, M., Mann, M.
10.1101/819607 — Posted: 2019-10-25
Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates
Bourdenx, M., Nioche, A., Dovero, S., Arotcarena, M.-L., Camus, S., Porras, G., Thiolat, M.-L., Rougier, N. P., Prigent, A., Aubert, P., Bohic, S., Sandt, C., Laferriere, F., Doudnikoff, E., Kruse, N., Mollenhauer, B., Novello, S., Morari, M., Leste-Lasserre, T., Trigo Damas, I., Goillandeau, M., Perier, C., Estrada, C., Garcia Carrillo, N., Recasens, A., Vaikath, N. N., El-Agnaf, O. M. A., Herrero Ezquerro, M. T., Derkinderen, P., Vila Bover, M., Obeso, J. A., Dehay, B., Bezard, E.
10.1101/825216 — Posted: 2019-10-31
Dopamine buffering capacity imaging: A pharmacodynamic fMRI method for staging Parkinson disease
Black, K. J., Acevedo, H. K., Koller, J. M.
10.1101/817106 — Posted: 2019-11-07

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