Channel:  Aligning Science Across Parkinson's (ASAP)

514 Articles

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Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease
Chou, C.-C., Vest, R., Prado, M. A., Wilson-Grady, J., Paulo, J. A., Shibuya, Y., Moran-Losada, P., Lee, T.-T., Luo, J., Gygi, S. P., Kelly, J. W., Finley, D., Wernig, M., Wyss-Coray, T., Frydman, J.
10.1101/2023.03.27.534444 — Posted: 2025-01-13
State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson's disease
Zhai, S., Cui, Q., Wokosin, D., Sun, L., Tkatch, T., Crittenden, J. R., Graybiel, A. M., Surmeier, D. J.
10.1101/2025.01.02.631090 — Posted: 2025-01-07
GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis
Bogacki, E. C., Longmore, G., Lewis, P. A., Herbst, S.
10.1101/2025.01.01.630988 — Posted: 2025-01-01
Neuronal alpha-Synuclein Disease stage progression over five years
Simuni, T., Gochanour, C., Nair, A. R., Brumm, M. C., Coffey, C., Poston, K. L., Chahine, L. M., Weintraub, D., Tanner, C. M., Gonzalez-Latapi, P., Kopil, C. M., Xiao, Y., Chowdhury, S., Dam, T., Pagano, G., Stephenson, D., Siderowf, A., Dunn, B., Marek, K., on behalf of the Parkinsons Progression Markers Initiative
10.1101/2024.12.17.24319172 — Posted: 2024-12-23
Anxa1+ dopamine neuron vulnerability defines prodromal Parkinson's disease bradykinesia and procedural motor learning impairment
Mantas, I., Contestabile, A., Skara, V., Loiseau, C., Santos, I., Cramb, K., Filograna, R., Wade-Martins, R., Magill, P., Meletis, K.
10.1101/2024.12.22.629963 — Posted: 2024-12-22
Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson's disease
Gaertner, Z., Oram, C., Schneeweis, A., Schonfeld, E., Bolduc, C., Chen, C., Dombeck, D. A., Parisiadou, L., Poulin, J. F., Awatramani, R.
10.1101/2024.06.06.597807 — Posted: 2024-12-22
The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson's disease mouse model
Morais, L. H., Stiles, L., Freeman, M., Oguienko, A. D., Hoang, J. D., Jones, J., Quan, B., Devine, J., Bois, J. S., Chou, T.-F., Trinh, J., Picard, M., Gradinaru, V., Mazmanian, S. K.
10.1101/2024.12.18.629251 — Posted: 2024-12-21
The pyrethroid insecticide deltamethrin disrupts neuropeptide and monoamine signaling pathways in the gastrointestinal tract
White, A. C., Krout, I. N., Mouhi, S., Chang, J., Kelly, S. D., Caudle, W. M., Sampson, T.
10.1101/2024.12.14.628386 — Posted: 2024-12-17
Parkinson's Disease Pathogenic Variants: Cross-Ancestry Analysis and Microarray Data Validation
Hong, S., Koretsky, M. J., Lichtenberge, J., Leonard, H., Pitz, V., Global Parkinson's Genetics Program (GP2)
10.1101/2024.12.16.24319097 — Posted: 2024-12-17
Severe GBA1 variants drive the GBA-PD clinical phenotype: implications for counselling and clinical trials
Menozzi, E., Lucas Del Pozo, S., Macnaughtan, J., Mezabrovschi, R., Koletsi, S., Mitrotti, P., Gallo, L., Calabrese, R., Toffoli, M., Loefflad, N., Valzania, F., Cavallieri, F., Fioravanti, V., Yalkic, S., Limbachiya, N., Blandini, F., Avenali, M., Schapira, A. H.
10.1101/2024.12.09.24318560 — Posted: 2024-12-16

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