COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,363 Articles (22,803 medRxiv, 8,560 bioRxiv)

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Changing impact of COVID-19 vaccination on COVID-19 mortality in the SARS-CoV-2 omicron variant period, 2022-2025
Liu, B., Stepien, S., Macartney, K.
10.1101/2025.11.20.25340696 — Posted: 2025-11-21
The effect of BCG vaccination on adult mortality during the COVID-19 pandemic: a meta-analysis of randomised controlled trials
Schaltz-Buchholzer, F., Curtis, N., Diacon, A. H., Giamarellos-Bourboulis, E. J., Kotsaki, A., Rosendahl Madsen, A. M., Messina, N. L., Nhamussua, L., Nielsen, S., Pittet, L. F., Silva, I., Sparrow, A., Upton, C., van Werkhoeven, C. H., Netea, M. G., Stabell Benn, C., Aaby, P.
10.1101/2025.11.19.25340570 — Posted: 2025-11-21
Whole genome sequence meta-analyses reveal common and rare genetic associations with critical COVID-19
Kousathanas, A., Rawlik, K., Pairo-Castineira, E., Griffiths, F., Oosthuyzen, W., Clohisey Hendry, S., Malinauskas, T., Butler-Laporte, G., Arumugam, P., Begg, C., Chadeau-Hyam, M., Chan, G., Cooke, G., Donovan, S., Elgar, G., Fowler, T. A., Goddard, P., Hinds, C., Horby, P., Ling, L., Magavern, E. F., Maleady-Crowe, F., Montgomery, H., Odhams, C. A., Openshaw, P. J. M., Patch, C., Rendon, A., Salehi, S., Scott, R. H., Semple, M. G., Shankar-Hari, M., Siddiq, A., Stuckey, A., Summers, C., Todd, L., Walker, S., Walsh, T., Ward, H., Zainy, T., GenOMICC Investigators, , ISARIC4C Investigators
10.1101/2025.11.19.25340573 — Posted: 2025-11-21
Increased mannosylation of extracellular vesicles in Long COVID plasma provides a potential therapeutic target for Galanthus nivalis agglutinin (GNA) affinity resin
Pesqueira Sanchez, M. A., de Necochea Campion, R., Dalhuisen, T., Fehrman, E. A., Chhabra, P. S., Kelly, J. D., Martin, J. N., Deeks, S. G., Henrich, T. J., Peluso, M. J., LaRosa, S. P.
10.1101/2025.11.21.689519 — Posted: 2025-11-21
Antigen-reactive CD4+ T cells after SARS-CoV-2 vaccination show divergent phenotypic states with or without restimulation bias
Kocher, K., Drost, F., Schuelein, C., Spriewald, B., Schubert, B., Schober, K.
10.1101/2025.11.19.688845 — Posted: 2025-11-21
Prediction of Long COVID and Mortality among Patients with Substance Use Disorder
Wu, J., Islam, K. M. S., Madiraju, P.
10.1101/2025.11.19.25340587 — Posted: 2025-11-20
A highly divergent cryptic SARS-CoV-2 lineage exhibits strong receptor binding and immune evasion
Feng, Z., Teo, Q. W., Ibrahim, B. A., Liu, W., Zhang, D., Mao, K. J., Shao, E. K., Gregory, D. A., Wilson, I. A., Johnson, M. C., Yuan, M., Wu, N. C.
10.1101/2025.11.18.25340485 — Posted: 2025-11-20
Omicron evolution drives increased ciliated cell tropism and dysfunction in nasal epithelia.
Parry, R., Mostafavi, H., McCallum, G., Sng, J. D. J., Joensuu, M., Short, K. R., Slonchak, A., Khromykh, A.
10.1101/2025.11.19.689397 — Posted: 2025-11-20
Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice
Mignolet, M., Deroux, C., Florkin, T., Bielarz, V., De Swert, K., Halloin, N., Sprimont, L., Ladang, A., George, F., Gilloteaux, J., Abeloos, L., Van Weyenbergh, J., Jamoulle, M., Diederich, C., Gillet, N. A., Bulpa, P., Nicaise, C.
10.1101/2025.11.20.689423 — Posted: 2025-11-20
Humoral immunity induced by LP.8.1 monovalent vaccines against a broad range of SARS-CoV-2 variants including XEC, NB.1.8.1, XFG, and BA.3.2
Kaku, Y., Fujiwara, M., Uriu, K., Yo, M. S., Kawakubo, S., Ito, J., Itoh, N., Uwamino, Y., Saito, F., Satoh, H., The Genotype to Phenotype Japan (G2P-Japan) Consortium, , Sato, K.
10.1101/2025.11.18.689152 — Posted: 2025-11-20

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).