Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
https://biorxiv.org
This feed contains articles for Collection "COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv"
bioRxivbioRxiv/medRxiv
https://biorxiv.org
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Meningitis vaccination campaign in the context of COVID-19 in Cameroon
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https://www.medrxiv.org/content/10.64898/2026.06.02.26354702v1?rss=1"
Mbang, M. A.Cheuyem, F. Z. L.Tchamani, R.Debnet, J.Ebongo, Z. N.Fouda, A. A. B.2026-06-04doi:10.64898/2026.06.02.26354702Cold Spring Harbor Laboratory Press2026-06-04
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Shared epigenetic regulation acting on neuroimmune pathways contributes to the comorbidity between generalized anxiety disorder and COVID-19
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https://www.medrxiv.org/content/10.64898/2026.06.03.26354830v1?rss=1"
Karaca, S.Cabrera Mendoza, B.He, J.Qiu, D.Davtian, D.Lacobelle, A.Nunez, Y. Z.Krystal, J. H.Pietrzak, R. H.Gelernter, J.Polimanti, R.2026-06-04doi:10.64898/2026.06.03.26354830Cold Spring Harbor Laboratory Press2026-06-04
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Pooled testing for SARS-CoV-2 surveillance in schools: real-world evaluation of transmission control, testing resources, and educational disruption
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https://www.medrxiv.org/content/10.64898/2026.06.03.26354821v1?rss=1"
Colosi, E.Calmon, L.Fässli, M.Koch, K.Bielicki, J. A.Colizza, V.2026-06-04doi:10.64898/2026.06.03.26354821Cold Spring Harbor Laboratory Press2026-06-04
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Insights from Wastewater Surveillance of SARS-CoV-2 in Skilled Nursing Facilities: Comparing Virus Concentration Methods for Wastewater and Correlating Wastewater Virus Concentrations with Clinical Infections, Georgia, USA, 2022
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https://www.medrxiv.org/content/10.64898/2026.06.01.26354622v1?rss=1"
Whitehill, F.Lyons, A. K.Abera, B.Adler, C.Burgos-Garay, M.Campbell, M.Santiago, A. J.Ganim, C.Moore, J.Cahela, Y.Lenz, S.Gable, P.Medrzycki, M.Walters, M. S.Keaton, A.Cook, P. W.Li, Y.Tao, Y.Zhang, J.Malapati, L.Retchless, A. C.Tong, S.Williams, M.Donlan, R.Coulliette-Salmond, A.2026-06-04doi:10.64898/2026.06.01.26354622Cold Spring Harbor Laboratory Press2026-06-04
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Interferon-gamma induced RNF213 targets nascent double membrane vesicles to inhibit coronavirus primary translation
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https://www.biorxiv.org/content/10.64898/2026.06.02.729663v1?rss=1"
Tartell, M. A.Tissawak, R.Voss, L.Lodha, M.Bianco, C.Iwamoto, M.Poston, D.Hatziioannou, T.Weisblum, Y.Bieniasz, P. D.2026-06-04doi:10.64898/2026.06.02.729663Cold Spring Harbor Laboratory Press2026-06-04
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A designed overlapping variant immunogen pool elicits broad sarbecovirus neutralization
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https://www.biorxiv.org/content/10.64898/2026.06.03.729821v1?rss=1"
Zang, T.Baharani, V. A.Aldis, M.Canis, M.Patejak, R.Osei Kuffour, E.Hoffman, H. H.van Bakel, H.Sordillo, E. M.Simon, V.MacDonald, M. R.Rice, C. M.Nussenzweig, M. C.Haziionannou, T.Bieniasz, P. D.2026-06-04doi:10.64898/2026.06.03.729821Cold Spring Harbor Laboratory Press2026-06-04
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Systems-Scale Structural Modeling Reveals the Germline Architecture of Immunodominance
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https://www.biorxiv.org/content/10.64898/2026.06.02.729678v1?rss=1"
Shrock, E. L.Sun, E.Dhindsa, A.Witwer, M. H.Yu, Z.Ivanochko, D.Lee, I.-H.Coventry, B.Borras Gonzalez, M.Julien, J.-P.Elledge, S. J.Baker, D.2026-06-04doi:10.64898/2026.06.02.729678Cold Spring Harbor Laboratory Press2026-06-04
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No objective evidence of neuropsychological deficits in people with subjective cognitive changes following COVID-19 infection
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https://www.biorxiv.org/content/10.64898/2026.06.03.723612v1?rss=1"
Abram, S.Dal Bon, K.Mathalon, D. H.Fryer, S. L.Song, S.Naeem, Z.Tang, N.Pulliam, L.Ford, J. M.2026-06-04doi:10.64898/2026.06.03.723612Cold Spring Harbor Laboratory Press2026-06-04
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Hierarchical classification of immune cell transcriptomes at population-scale
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https://www.biorxiv.org/content/10.64898/2026.05.30.728980v1?rss=1"
Beltz, C.Qiu, Z.Sadowski, L.Kraske, J. A.Aggarwal, A.Quintanal-Villalonga, A.Manoj, P.Littbarski, A.Bajaj, S.Meskauskaite, B.Umeda, S.Mazutis, L.Rose, S. A.Chan, J. M.Nawy, T.Nainys, J.Chaligne, R.de Stanchina, E.Kaelber, K. A.Cussigh, C. S.Kallenberger, S. M.Williams, A.Jenzer, M.Pompecki, T.Kahle, S.Hohmann, N.Nussbaum, D. P.Moss, N. S.Ziv, E.Berger, A. K.Springfeld, C.Zschaebitz, S.Hassel, J. C.Debus, J.Jaeger, D.Iacobuzio-Donahue, C. A.Ganesh, K.Peer, D.Ungerechts, G.Rudin, C. M.Huber, P. E.Walle, T.2026-06-04doi:10.64898/2026.05.30.728980Cold Spring Harbor Laboratory Press2026-06-04
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Rationale and Design of RECOVER-ENERGIZE: A Platform Clinical Trial of Interventions for Exercise Intolerance With and Without Post-exertional Malaise in Long COVID
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https://www.medrxiv.org/content/10.64898/2026.06.02.26354455v1?rss=1"
Friedly, J.Bateman, L.Berdan, L. G.Casaburi, R.Erdmann, N.Felker, G. M.Itchon-Ramos, N.Keteyian, S. J.MacIntyre, N. R.OBrien, L.Reist, C.Rossiter, H. B.Silverstein, A. P.Taylor, E.Pike Welch, H.Yanez, N. D.Zimmerman, K. O.Make, B.2026-06-03doi:10.64898/2026.06.02.26354455Cold Spring Harbor Laboratory Press2026-06-03
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Simple cumulative weighting of routine surveillance data identifies epidemic wave origins more accurately than a large language model: evidence from eight COVID-19 waves in Japan
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https://www.medrxiv.org/content/10.64898/2026.06.02.26354691v1?rss=1"
Nakagawa, S.Yamamoto, A.2026-06-03doi:10.64898/2026.06.02.26354691Cold Spring Harbor Laboratory Press2026-06-03
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SARS-CoV-2 BA.3.2.2 is more evasive of neutralization by sera from young children
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https://www.biorxiv.org/content/10.64898/2026.06.01.728533v1?rss=1"
Wu, M.Hong, H.Guo, Y.Daniel, K.Hisner, R.Johnson, M. C.Gordon, A.Ho, D. D.Mellis, I. A.2026-06-03doi:10.64898/2026.06.01.728533Cold Spring Harbor Laboratory Press2026-06-03
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Chronic cocaine exposure negatively impacts Long-COVID-like outcomes produced by the SARS-CoV-2 spike protein in the rat
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https://www.biorxiv.org/content/10.64898/2026.06.02.729575v1?rss=1"
Davis, S. E.Stern, D. R.Inan, S.Vu, E.Lopez, D.Anwuri, F.Ghilotti, M. G.Meissler, J. J.Unterwald, E. M.2026-06-02doi:10.64898/2026.06.02.729575Cold Spring Harbor Laboratory Press2026-06-02
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org.highwire.dtl.DTLVardef@1193144org.highwire.dtl.DTLVardef@f189c6org.highwire.dtl.DTLVardef@18c3c30org.highwire.dtl.DTLVardef@1c3a037_HPS_FORMAT_FIGEXP M_FIG C_FIG
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A Viral Mutation Profiling and Discovery Strategy for Sensitive Multiplex Detection of Viruses and Variants in Saliva by Proteomics
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https://www.biorxiv.org/content/10.64898/2026.05.30.729008v1?rss=1"
Zhang, Y.Shortreed, M.Timperman, A. T.2026-06-02doi:10.64898/2026.05.30.729008Cold Spring Harbor Laboratory Press2026-06-02
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Structural Basis for Inhibition of the HKU5-CoV Main Protease by Clinical SARS-CoV-2 Protease Inhibitors
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https://www.biorxiv.org/content/10.64898/2026.06.01.729201v1?rss=1"
Kim, H.Ahn, J.Lee, J.Jung, S.Kim, J. W.Kim, B.Ha, N.-C.Jo, I.2026-06-02doi:10.64898/2026.06.01.729201Cold Spring Harbor Laboratory Press2026-06-02
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Data aggregation and mechanistic modeling enable dose-response analysis of SARS-CoV-1 in non-human primates
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https://www.biorxiv.org/content/10.64898/2026.06.01.729195v1?rss=1"
Lee, P. C.Snedden, C. E.Morris, D. H.Lloyd-Smith, J.2026-06-01doi:10.64898/2026.06.01.729195Cold Spring Harbor Laboratory Press2026-06-01
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Immune context unmasks regulatory effects of Neanderthal and Denisovan introgression
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https://www.biorxiv.org/content/10.64898/2026.05.29.727880v1?rss=1"
Li, Z.kerner, g.Mendoza-Revilla, J.Inoue, F.Fishilevich, S.Patin, E.Gokhman, D.Quintana-Murci, L.Rotival, M.2026-06-01doi:10.64898/2026.05.29.727880Cold Spring Harbor Laboratory Press2026-06-01
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A Monoclonal Antibody Panel to Track Ongoing Antigenic Evolution of SARS-CoV-2 Variants
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https://www.biorxiv.org/content/10.64898/2026.05.29.728770v1?rss=1"
Wu, M.Hong, H.Chong, S.Yu, J.Mellis, I. A.Huang, C.-Y.Wang, Q.Huang, Y.Guo, Y.Ho, D. D.2026-06-01doi:10.64898/2026.05.29.728770Cold Spring Harbor Laboratory Press2026-06-01
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Towards understanding of NK cell antigenic specificity
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https://www.biorxiv.org/content/10.64898/2026.05.29.728791v1?rss=1"
Ustiuzhanina, M. O.Shagina, I. A.Nikitin, E.Klimuk, E.Britanova, O.Ventura-Carmenate, Y.Kovalenko, E.Chudakov, D. M.2026-06-01doi:10.64898/2026.05.29.728791Cold Spring Harbor Laboratory Press2026-06-01 40 glycosyltransferases. In peptide culturing autologous assays, SARS-CoV-2 (KTFPPTEPK) and EBV (CRAKFKHLL) peptides elicited NK cell proliferation and distinct transcriptional programs linking cytotoxicity genes, KIR2DS4 and glycosyltransferases. Structural modeling revealed that N-linked glycosyl residues in specific regions of KIR2DS4 may alter its contacts and interaction with MHCI and the presented peptide. We conclude that KIR human NK cells comprise clonally imprinted populations with distinct glycosyltransferase expression profiles, and site-specific KIR2DS4 glycosylation may modulate interaction with peptide-MHCI complexes, suggesting a post-translational layer of clonal NK cell diversification as a clue to their antigenic specificity.
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COVID-19 vaccine effectiveness in children under 5 in the USA: a test-negative case-control study
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https://www.medrxiv.org/content/10.64898/2026.05.28.26354328v1?rss=1"
Silverman, R. A.Ahrens, M. L.Helmick, M.Finkielstein, C. V.Cohen, A.Short, E.Bordwine, P.2026-05-30doi:10.64898/2026.05.28.26354328Cold Spring Harbor Laboratory Press2026-05-30
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Pre-pandemic blood profiles predict COVID-19 hospitalization and death a decade later
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https://www.medrxiv.org/content/10.64898/2026.05.27.26354230v1?rss=1"
Jacobs, L. A.2026-05-29doi:10.64898/2026.05.27.26354230Cold Spring Harbor Laboratory Press2026-05-29
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Preorganized RdRp-Thumb Dynamics Drives SARS-CoV-2 Polymerase Function
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https://www.biorxiv.org/content/10.64898/2026.05.29.728794v1?rss=1"
Gibbs, H.Butuc, A.Moore, P. B.Gianti, E.2026-05-29doi:10.64898/2026.05.29.728794Cold Spring Harbor Laboratory Press2026-05-29
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Late induction of IgG4 following SARS-CoV-2 mRNA vaccination in pregnant and non-pregnant individuals includes clonotypes raised early in the response
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https://www.biorxiv.org/content/10.64898/2026.05.29.728639v1?rss=1"
Kansara, D. N.Yu, T.-G.Kansara, N.Taher, N. M.Yesbalatova, A.DeBrabandere, L.Weiner, J. A.Kovacikova, G.Hederman, A. P.Pannus, P.Depickere, S.Goosens, M. E.Vercoutere, A.Dauby, N.Arien, K. K.Maertens, K.Marchant, A.Lee, J.Ackerman, M. E.2026-05-29doi:10.64898/2026.05.29.728639Cold Spring Harbor Laboratory Press2026-05-29
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A 667-nucleotide sequence in the SARS-CoV-2 nsp15 coding region promotes genome encapsidation
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https://www.biorxiv.org/content/10.64898/2026.05.29.721935v1?rss=1"
Yao, S.Gontu, A.Atkins, J.Byukusenge, M.Jakka, P.Worwa, G.Kuhn, J.Kuchipudi, S.Archetti, M.2026-05-29doi:10.64898/2026.05.29.721935Cold Spring Harbor Laboratory Press2026-05-29
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org.highwire.dtl.DTLVardef@1b64611org.highwire.dtl.DTLVardef@1b21b7borg.highwire.dtl.DTLVardef@2a68b5org.highwire.dtl.DTLVardef@405fe1_HPS_FORMAT_FIGEXP M_FIG O_FLOATNOGRAPHICAL ABSTRACTC_FLOATNO A part of the nsp15 coding sequence of SARS-CoV-2 promotes efficient transmission of defective viral genomes in vitro and in vivo. Using a sequential deletion library and targeted deletions within this region we identify RNA structures that may function as packaging signals.
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Dysregulated dsRNA sensor signaling and viral infection during onset of pediatric autoimmune interferonopathy
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https://www.biorxiv.org/content/10.64898/2026.05.27.728148v1?rss=1"
MOREAU, T. R.AQUINO, Y.ZHU, Y. Y.BONDET, V.ALBERT-VEGA, C.DONNADIEU, F.DUBOIS, F.PERIOU, B.RAHAL, F.TIZERARINE, M.VELDKAMP, S. R.VILLAIN, E.BERTRAND, A.BODEMER, C.BRUNAUD, C.FREMOND, M.-L.FOURNIER, B.HOAREAU, B.QUARTIER, P.AUTHIER, F.-J.SARDA, E.SCHVARTZ, A.VINIT, A.VAN ROYEN-KERKHOF, A.VAN WIJK, F.WELFRINGER-MORIN, A.RIEUX-LAUCAT, F.JANSEN, M.HING, D.TRABOULSI, T.MORAES-CABE, C.HASAN, M.HARDY, D.WHITE, M.QUINTANA-MURCI, L.MELKI, I.BADER-MEUNIER, B.GITIAUX, C.RODERO, M. P.DUFFY, D.2026-05-29doi:10.64898/2026.05.27.728148Cold Spring Harbor Laboratory Press2026-05-29
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The biodistribution and effect of post-exposure neutralising monoclonal antibody treatment in a mouse model of SARS-CoV-2 infection with viral spread to the brain
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https://www.biorxiv.org/content/10.64898/2026.05.27.728081v1?rss=1"
Schlaepfer, J. A.De Neck, S.Penrice-Randal, R.Sharma, P.Kirby, A.Tatham, L.Gallardo Toledo, E.Herriott, J.Kijak, E.Sharp, J.Stewart, J. P.Owen, A.Kipar, A.2026-05-29doi:10.64898/2026.05.27.728081Cold Spring Harbor Laboratory Press2026-05-29
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Increased burden of influenza A/H1N1pdm09 in older adults following the COVID-19 pandemic
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https://www.medrxiv.org/content/10.64898/2026.05.20.26353664v1?rss=1"
de Jong, S. P. J.Russell, C. A.2026-05-28doi:10.64898/2026.05.20.26353664Cold Spring Harbor Laboratory Press2026-05-28300,000 subtyped, age-stratified infections), we report a substantially increased contribution of A/H1N1pdm09 to influenza morbidity in older adults since approximately 2022. Birth cohort-stratified analyses suggest elevated A/H1N1pdm09 burden among individuals born before 1955-1959, consistent with erosion of pre-existing immunity originally generated by exposure to historical A/H1N1 strains. Pooled estimates across datasets and analytical approaches indicate the increase in A/H1N1pdm09 burden rises with earlier birth year, ranging from 1.22-fold (95% CI 1.08-1.37) for the 1955-1959 birth cohort to 3.10-fold (95% CI 2.58-3.72) for the 1930-1934 cohort. These findings point to a substantial rise in the overall influenza burden among the most vulnerable age groups, with implications for vaccine policy, clinical management, and public health planning.
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SARS-CoV-2 Antibody Response during Omicron Predominance after COVID-19 Vaccination in People Living with HIV: A Comparative Study in Canada and Burkina Faso
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https://www.medrxiv.org/content/10.64898/2026.05.26.26354060v1?rss=1"
Jarras, H.Bazie, W. W.Blais, I.Pakenham, A.Valiquette, j.Theriault, M.Traore, I. T.Kania, D.Ouoba, A. R.Zoundi, Y.Pelletier, M.Tessier, P. A.Pouliot, M.Trottier, S.Vachon, M.-L.Gilbert, C.2026-05-28doi:10.64898/2026.05.26.26354060Cold Spring Harbor Laboratory Press2026-05-28
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Dynamic Topic Alignment and Sentiment between Official Health Communication and General Public Discourse during COVID-19: A Comprehensive Infoveillance Framework
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https://www.medrxiv.org/content/10.64898/2026.05.23.26353966v1?rss=1"
Yin, S.Xin, W.Chen, S.Ge, Y.2026-05-27doi:10.64898/2026.05.23.26353966Cold Spring Harbor Laboratory Press2026-05-27
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Antibody Transcytosis and Neutralizing Activity in Respiratory Epithelial Cells
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https://www.biorxiv.org/content/10.64898/2026.05.25.727697v1?rss=1"
Anaya, E.Vue, Y.Li, M.Resnick, J.Swanson, N. J.Sullivan, D. J.Pekosz, A.2026-05-27doi:10.64898/2026.05.25.727697Cold Spring Harbor Laboratory Press2026-05-27
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Two anti-phase spatial modes and a candidate spatial-persistence regime transition of SARS-CoV-2 in Japan: a 159-week prefecture-level sentinel surveillance study
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https://www.medrxiv.org/content/10.64898/2026.05.24.26353972v1?rss=1"
Nakano, T.Onozuka, D.Ikeda, Y.Washiyama, K.Takashima, Y.2026-05-26doi:10.64898/2026.05.24.26353972Cold Spring Harbor Laboratory Press2026-05-26
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Antigenic characterization of SARS-CoV-2 variants BA.3.2.1 and BA.3.2.2 in three animal models
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https://www.biorxiv.org/content/10.64898/2026.05.24.727525v1?rss=1"
Turner, S. A.Olivier, J.Ellis, M. L.Floyd, K. A.Lai, L.Scheaffer, S. M.Hastings, I.Darling, T. L.Miller, B. A.Patel, C. J.Peck, H.Vanover, D.Santangelo, P. J.Diamond, M. S.Suthar, M. S.Boon, A. C. M.Smith, D. J.2026-05-26doi:10.64898/2026.05.24.727525Cold Spring Harbor Laboratory Press2026-05-26
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Epistatic evolution drives HLA-dependent CD8+ T Cell escape risk in diverse populations
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https://www.biorxiv.org/content/10.64898/2026.05.22.727291v1?rss=1"
Hamelin, D. J.Grenier, J.-C.Poujol, R.Bourdin, B.Pare, B.Simpson, S.Smith, M.Decaluwe, H.Caron, E.Hussin, J.2026-05-26doi:10.64898/2026.05.22.727291Cold Spring Harbor Laboratory Press2026-05-26
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Substrate and target selectivity of 4'-fluoroadenosine against viral and host polymerases
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https://www.biorxiv.org/content/10.64898/2026.05.22.727251v1?rss=1"
Walker, S. M.Loutan, A. J.Tchesnokov, E. P.Kocincova, D.Gordon, C. J.Escobedo, R. A.Jackson, N.Vogel, O. A.Morsheimer, K.Park, S.Gharpure, A.Urbano, I.Heacock, M.Cheng, Z.Pathak, K.Wolff, K. C.Huerta, L.Bakowski, M. A.Riva, L.Gupta, A. K.Yu, C.Das, K.Martinez-Sobrido, L.Basler, C. F.Davey, R. A.Wilson, I. A.Ward, A. B.Chanda, S.Chatterjee, A. K.Gotte, M.2026-05-26doi:10.64898/2026.05.22.727251Cold Spring Harbor Laboratory Press2026-05-26
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Low seroprevalence of neutralizing antibodies to gorilla adenovirus 32 (GRAd32) in southern African populations supports evaluation of this vector platform for HIV vaccine development
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https://www.biorxiv.org/content/10.64898/2026.05.23.726423v1?rss=1"
Mkhize, N. N.patjane, A.Shusha, N.Welsh, A.Hermanus, T.Kgagudi, P.Motlou, T.Bekker, L.-G.Gray, G.Garrett, N.Fairlie, L.Sigal, A.Burgers, W.Mangwaku, T.Makadzange, T.Colloca, S.Folgori, A.Moyo-Gwete, T.Gentile, M.Capone, S.Moore, P. L.2026-05-26doi:10.64898/2026.05.23.726423Cold Spring Harbor Laboratory Press2026-05-26200 previously shown to impact vaccine efficacy. Gorilla adenovirus (GRAd) vectors have been developed to evade pre-existing anti-vector responses, but their seroprevalence in southern Africa is poorly defined. Here, we assessed seroprevalence to GRAd32, Ad26 and Ad5 before (baseline) and after COVID-19 vaccination, in cohorts from South Africa and Zimbabwe.
Sera from South African participants enrolled in the Sisonke sub-study (n=100, prior to Ad26.COV2.S vaccination) and the follow-up "Booster after Sisonke" (BaSiS) study (n=226) were tested for neutralizing antibodies to Ad5, Ad26, and GRAd32. These samples included paired pre/post boost samples for 27 donors. We also tested sera from the Zimbabwean Mutala cohort (n=131, of which 44 were unvaccinated, and 87 vaccinated with inactivated vaccines). Participants living with HIV (PLWH) comprised 30-50% of each cohort.
In the pre-vaccination samples from the Sisonke cohort, geometric mean titers (GMT) for anti-GRAd32, Ad26, and Ad5 antibodies were 78, 142, and 459, with neutralization titers >200 observed in 14%, 32%, and 68% of participants, respectively. Similarly, in the unvaccinated participants in the Mutala cohort, GMTs for GRAd32, Ad26, and Ad5 were 117, 245, and 536, with neutralizing titers >200 in 22%, 42%, and 69% of participants. We observed no significant difference in Ad antibody titers between PLWH and those living without HIV. We next assessed the impact of COVID-19 vaccination on titers. Vaccination with inactivated COVID-19 vaccines (Sinopharm/Sinovac) did not significantly affect Ad5, Ad26 or GRAd32 titers in an unpaired analysis. In contrast, [~]9 months after Ad26.COV2.S vaccination, anti-Ad26 titers for longitudinally sampled participants (n=27) increased 10-fold from a GMT of 141 to 1,426. By comparison, GRAd32 responses were not significantly altered by Ad26.COV2.S vaccination, while anti-Ad5 responses showed a modest <2-fold increase.
Our data support previous findings that, whereas anti-Ad5 neutralizing antibody responses are commonly detected globally, GRAd32 responses are less frequent. Importantly, GRAd32 neutralizing responses remained unchanged after Ad26.COV2.S vaccination. HIV status had no significant effect on antibody titers. These results support the use of the GRAd32 vector in upcoming HIV vaccine trials, including in regions where Ad26-based COVID-19 vaccines were widely deployed.
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Cumulative In-Context Learning versus Simple Historical Weighting for Real-Time Geographic Origin Identification of Ongoing Epidemic Waves: A Comparative Evaluation Using Eight COVID-19 Waves in Japan
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https://www.medrxiv.org/content/10.64898/2026.05.23.26353936v1?rss=1"
Nakagawa, S.Yamamoto, A.2026-05-25doi:10.64898/2026.05.23.26353936Cold Spring Harbor Laboratory Press2026-05-25
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Predictors of maternal mental health and coping during the COVID-19 pandemic: A multi-country cross-sectional study
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https://www.medrxiv.org/content/10.64898/2026.05.25.26353920v1?rss=1"
Liu, C.Liu, M.Dib, S.Ferrando, M.Kagawa, M.Ongprasert, K.Rougeaux, E.Shukri, N. H. M.Vazquez, A.Wells, J.Fewtrell, M.Yu, J.2026-05-25doi:10.64898/2026.05.25.26353920Cold Spring Harbor Laboratory Press2026-05-25
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Rapid in vitro synthesis of DNA templates via Sidewinder for polyadenylated Hantavirus mRNA vaccine candidates
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https://www.biorxiv.org/content/10.64898/2026.05.22.727328v1?rss=1"
Abraham, E.Andrade, J.Davis, A.Gawda, T.Glanville, J.Graves, D.Huang, J.Hur, J.Kim, S.Paul, J.-S.Robinson, N. E.Sanfiorenzo, C.Wang, S.Zhang, R. J.Zhang, W.Zhao, T.Zhou, J.Wang, K.2026-05-25doi:10.64898/2026.05.22.727328Cold Spring Harbor Laboratory Press2026-05-25
<![CDATA[
TRENDS-Thai: decadal trends of dengue, chikungunya, and hand, foot, and mouth disease in Thailand (2016-2025): a multi-disease time-series analysis of COVID-19 disruption
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https://www.medrxiv.org/content/10.64898/2026.05.21.26353796v1?rss=1"
Pongpirul, W.Ahmed, M. M.Pongpirul, K.2026-05-24doi:10.64898/2026.05.21.26353796Cold Spring Harbor Laboratory Press2026-05-24
<![CDATA[
Effect of Antiseptic Mouthwash/Gargling Solutions on SARS-CoV-2 Viral Load: A Randomized Clinical Trial
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https://www.medrxiv.org/content/10.64898/2026.05.20.26353686v1?rss=1"
Banava, S.Radaic, A.Pachiyappan, K.Cheng, N. F.Hernandez-Kapila, Y. L.Gansky, S. A.2026-05-22doi:10.64898/2026.05.20.26353686Cold Spring Harbor Laboratory Press2026-05-22
<![CDATA[
Caregiving Demands and Depression Symptoms among Caregivers of Individuals with Down Syndrome during the COVID-19 Pandemic
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https://www.medrxiv.org/content/10.64898/2026.05.20.26353699v1?rss=1"
Nguyen, J.Wall, C.Jo, E.Allen, L. K.Wheeler, N.Baumer, N.D'Aguilar, A.York, T. P.Capone, G.Jackson-Cook, C.Amstadter, A. B.Brown, R. C.2026-05-22doi:10.64898/2026.05.20.26353699Cold Spring Harbor Laboratory Press2026-05-22
<![CDATA[
A longitudinal cohort study comparing clinical trials registered on ClinicalTrials.gov that stopped during the first three years of the SARS-CoV-2 pandemic with trials that stopped in the three years prior
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https://www.medrxiv.org/content/10.64898/2026.05.20.26353581v1?rss=1"
Carlisle, B. G.Hutchinson, N.Moyer, H.2026-05-22doi:10.64898/2026.05.20.26353581Cold Spring Harbor Laboratory Press2026-05-22
<![CDATA[
Ischemic stroke after bivalent mRNA COVID-19 vaccination and influenza vaccination during the 2022-2023 season: a multi-site self-controlled case series study
]]>
https://www.medrxiv.org/content/10.64898/2026.05.20.26353716v1?rss=1"
Xu, S.Sy, L. S.Hong, V.Farrington, P.Glenn, S. C.Kim, S.Ryan, D. S.Tubert, J. E.Tong, P.Lewin, B. J.Tseng, H. F.Carbayo, A.Davis, C.Sangha, N. S.Belongia, E. A.Sundaram, M. E.Nelson, J. C.Daley, M. F.Klein, N. P.Fireman, B.Haapala, J.Hurley, L. P.Irving, S. A.Cocoros, N. M.Weintraub, E. S.Duffy, J.Qian, L.2026-05-22doi:10.64898/2026.05.20.26353716Cold Spring Harbor Laboratory Press2026-05-2265 years) and history of documented SARS-CoV-2 infection.
ResultsA total of 6,510 first-ever ischemic strokes were identified among more than 6.8 million participants. Among recipients of Pfizer-BioNTech bivalent COVID-19 and influenza vaccines, no statistically significant increased risk of first-ever ischemic stroke was observed following bivalent COVID-19 vaccination (RI = 0.94; 95% CI: 0.63-1.41), influenza vaccination (RI = 0.95; 95% CI: 0.82-1.10), or same-day coadministration (RI = 1.15; 95% CI: 0.88-1.49) within 1- 21-day risk intervals; findings were similar for 1-42-day intervals. Comparable null results were observed for Moderna vaccines and across all subgroups, secondary, and exploratory outcomes.
ConclusionNo increased risk of ischemic stroke was found following bivalent mRNA COVID-19 vaccination, influenza vaccination, or their coadministration in this multi-site SCCS study. These findings are consistent with previous studies and underscore the importance of continued vaccine safety monitoring.
HighlightsO_LIWe evaluated ischemic stroke risk after bivalent mRNA COVID-19 vaccination, influenza vaccination, and their coadministration.
C_LIO_LINo increased risk of ischemic stroke was observed within 1-21 or 1-42 days following these vaccination exposures.
C_LIO_LIFindings were consistent across vaccine type, age group, and prior SARS-CoV-2 infection status.
C_LIO_LIThese results support the safety of bivalent mRNA COVID-19 vaccines with respect to ischemic stroke.
C_LI
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<![CDATA[
Fronto-limbic and Thalamocortical Network Alterations after COVID-19 Recovery: a Multimodal MRI Study
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https://www.medrxiv.org/content/10.64898/2026.05.19.26353613v1?rss=1"
Mishra, S. S.Misra, R.Douaud, G.Biswal, B.Gandhi, T.2026-05-22doi:10.64898/2026.05.19.26353613Cold Spring Harbor Laboratory Press2026-05-220.05). Our findings indicate that COVID-19 recovery is associated with enduring alterations in fronto-limbic and thalamo-cortical circuits, most prominently in individuals with severe infection. Convergent structural and functional changes involving the orbitofrontal cortex and mediodorsal thalamus suggest network-specific reorganisation that may underpin persistent cognitive and affective symptoms of post-COVID syndrome.
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<![CDATA[
COVID-19 vaccination and the risk of cardiovascular and thromboembolic events after SARS-CoV-2 infection: a systematic review and meta-analysis
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https://www.medrxiv.org/content/10.64898/2026.05.21.26353568v1?rss=1"
Heymans, S.Heidecker, B.Marjenberg, Z.Green, R.Pliakas, T.Lip, G. Y. H.Lüscher, T. F.Abduljawad, S.2026-05-22doi:10.64898/2026.05.21.26353568Cold Spring Harbor Laboratory Press2026-05-22
<![CDATA[
Mitigation of imprinted antibody responses in elderly COVID-19 highly vaccinated individuals
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https://www.biorxiv.org/content/10.64898/2026.05.21.725708v1?rss=1"
Morse, R. B.Egan, D. J. S.Cheng, M. T. K.Altaf, M.Kamelian, K.Ceron-Gutierrez, L.Sokolova, O.Bradley, J.Smith, K. G. C.Doffinger, R.Tan, C. W.Gupta, R. K.2026-05-22doi:10.64898/2026.05.21.725708Cold Spring Harbor Laboratory Press2026-05-22
<![CDATA[
Force-regulated catch bonds and fusion peptide exposure drive coronavirus entry
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https://www.biorxiv.org/content/10.64898/2026.05.21.727024v1?rss=1"
Li, H.Li, Z.Gao, H.2026-05-22doi:10.64898/2026.05.21.727024Cold Spring Harbor Laboratory Press2026-05-22
<![CDATA[
Antioxidant properties of Rhodiola rosea
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https://www.biorxiv.org/content/10.64898/2026.05.21.726678v1?rss=1"
Brink, D. F.Sapp, T. L.Ghafoor, T. S.Boyland, P. A.Tamazawa, Y. C.Kaur, G.Shults, N. V.Sullivan, R. D.Suzuki, Y. J.2026-05-22doi:10.64898/2026.05.21.726678Cold Spring Harbor Laboratory Press2026-05-22
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Sexually Transmitted and Bloodborne Infections, Methamphetamine Use, and COVID-19 Vaccination in Manitoba, Canada: A Retrospective Matched Cohort Analysis Using Population-Based Administrative Healthcare Data (2020-2022)
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https://www.medrxiv.org/content/10.64898/2026.05.18.26353507v1?rss=1"
Shaw, S. Y. Y.Mahar, A.Bailey, K.Payne, M.Kindrachuk, J.Kelly, C.Friesen, K. J.Bernstein, C. N.Reimer, J.Becker, M. L.McClarty, L. M.Stein, D.Nickel, N. C.2026-05-21doi:10.64898/2026.05.18.26353507Cold Spring Harbor Laboratory Press2026-05-21
<![CDATA[
The control gap in long COVID research: a meta-epidemiological analysis
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https://www.medrxiv.org/content/10.64898/2026.05.16.26353381v1?rss=1"
Panagiotopoulos, A.-P.Laskaris, A.Tsakri, D.Manoussopoulos, Y.Anastassopoulou, C.Tsakris, A.Ioannidis, J.2026-05-21doi:10.64898/2026.05.16.26353381Cold Spring Harbor Laboratory Press2026-05-21
<![CDATA[
Predicting Functional Changes in Down Syndrome During the COVID-19 Pandemic: The Role of Biopsychosocial Determinants of Health
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https://www.medrxiv.org/content/10.64898/2026.05.19.26353577v1?rss=1"
Jo, E.Wall, C.Allen, L. K.Wheeler, N.Baumer, N.D'Aguilar, A.York, T. P.Capone, G.Jackson-Cook, C.Amstadter, A. B.Brown, R. C.2026-05-21doi:10.64898/2026.05.19.26353577Cold Spring Harbor Laboratory Press2026-05-21
<![CDATA[
Spike antibodies targeting GRP78 predispose to cardiovascular complications compared to Dengue
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https://www.biorxiv.org/content/10.64898/2026.05.20.726568v1?rss=1"
Sarker, S.Roy, T.Mallick, A.Das, S.Teja, S. D.Bandyopadhyay, A.Gorai, S.De, A.Biswas, S.2026-05-21doi:10.64898/2026.05.20.726568Cold Spring Harbor Laboratory Press2026-05-21
<![CDATA[
Ribophorin-1 Governs Spike Abundance of Highly Pathogenic Coronaviruses by ER-associated degradation
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https://www.biorxiv.org/content/10.64898/2026.05.20.726704v1?rss=1"
Huang, Y.-J.Lv, L.Ran, W.Zhao, H.Deng, Y.-Q.Ye, Q.Li, L.Wu, X.-Y.Chen, Q.Hu, Y.Sun, B.Zhao, J.-J.Zhao, J.Qin, C.2026-05-21doi:10.64898/2026.05.20.726704Cold Spring Harbor Laboratory Press2026-05-21
<![CDATA[
Occupational hierarchy, racialization, and COVID-19 health outcomes among meat processing plant workers in Alberta: a community-engaged mixed-methods study
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https://www.medrxiv.org/content/10.64898/2026.05.14.26353257v1?rss=1"
Essar, M. Y.Norrie, E.Cerino, E. R.Antonio, M.Saad, A.Yemane, M.Holdbrook, L.Sahilie, A.Youssef, M.Hassan, N.Magwood, O.Edwards, S. T.Spitzer, D.Coakley, A.Pottie, K.Fabreau, G. E.2026-05-20doi:10.64898/2026.05.14.26353257Cold Spring Harbor Laboratory Press2026-05-20
<![CDATA[
Exploring the genetic architecture of multimorbidity and its impact on long COVID risk
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https://www.medrxiv.org/content/10.64898/2026.05.18.26353402v1?rss=1"
Bauer, S. J. M.Bowyer, R. C. E.Bravo Merodio, L.Gkoutos, G.Vetrano, D.Jackson, T.Freidin, M. B.Steves, C. J.2026-05-20doi:10.64898/2026.05.18.26353402Cold Spring Harbor Laboratory Press2026-05-20
<![CDATA[
The Potential Clinical and Economic Impact of a Combination COVID-19 and Influenza Vaccine (mRNA-1083) in Canada
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https://www.medrxiv.org/content/10.64898/2026.05.18.26353482v1?rss=1"
Fust, K.Kohli, M.Cartier, S.Van de Velde, N.Mehta, D.Blake, M.2026-05-20doi:10.64898/2026.05.18.26353482Cold Spring Harbor Laboratory Press2026-05-20
<![CDATA[
Mechanochemical Decoupling of ATP Hydrolysis and RNA Translocation in SARS-CoV-2 nsp13 by the L405D Mutation
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https://www.biorxiv.org/content/10.64898/2026.05.18.726016v1?rss=1"
Fazelpour, E.Roy, P.Frederick, K.McCullagh, M.2026-05-20doi:10.64898/2026.05.18.726016Cold Spring Harbor Laboratory Press2026-05-20
<![CDATA[
Direct serological antibody discovery by integrative proteomics yields potent neutralizers overlooked by single-cell BCR sequencing
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https://www.biorxiv.org/content/10.64898/2026.05.20.725438v1?rss=1"
Tamara, S.van Rijswijck, D. M. H.van Rijswijk, J.Burger, J. A.Schulte, D.Moreschini, M.de Bree, G. J.van Gils, M. J.Heck, A. J. R.den Boer, M. A.2026-05-20doi:10.64898/2026.05.20.725438Cold Spring Harbor Laboratory Press2026-05-20
<![CDATA[
Wastewater Surveillance as an Event Detection System: Outbreak and Peak Detection of SARS-CoV-2 Across 281 U.S. Counties
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https://www.medrxiv.org/content/10.64898/2026.05.14.26353186v1?rss=1"
Link, N. B.Garrido, R.Nande, A.Santillana, M.2026-05-19doi:10.64898/2026.05.14.26353186Cold Spring Harbor Laboratory Press2026-05-19
<![CDATA[
How the COVID-19 pandemic and cost-of-living crisis shaped reach and engagement in the ECAIL trial targeting socially disadvantaged families: an interdisciplinary implementation study
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https://www.medrxiv.org/content/10.64898/2026.05.14.26353230v1?rss=1"
Poquet, D.Le Gal, C.Hincker, P.Beghin, L.Deplanque, D.Subtil, D.Sion, O.Cavalli, B.VANHOUTTE, L.Jacobsen, V.Marr, K.Sakellaris, I.de Lauzon Guillain, B.Charles, M.-A.Ley, D.Sauvegrain, P.Lioret, S.2026-05-19doi:10.64898/2026.05.14.26353230Cold Spring Harbor Laboratory Press2026-05-19
<![CDATA[
The SARS-CoV-2 Integrated Genomic Epidemiology Database (IGED): Linking viral genomes with patient-level metadata to advance statewide genomic surveillance in California
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https://www.medrxiv.org/content/10.64898/2026.05.14.26353263v1?rss=1"
Ryder, R.Elder, J.Panditrao, M.Grosgebauer, K.Katz, R.Tello, L.Carroll, E.Borthwick, D.Kaur, C.Smith, R.Shiau, V.Wheeler, W.Reilly, E.Myers, J.Nelson, L.Lim, E.Arunleung, P.Baylis, E.Gilliam, S.Hennesy-Burt, T.Bregman, B.Silver, E.Kapsak, C.Wright, S.Leon, T.Bell, J.Morales, C.Wadford, D. A.2026-05-19doi:10.64898/2026.05.14.26353263Cold Spring Harbor Laboratory Press2026-05-19
<![CDATA[
SARS-CoV-2 Vaccination Status and MIS-C Incidence: A Systematic Review
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https://www.medrxiv.org/content/10.64898/2026.05.15.26353349v1?rss=1"
Katherine Carroll, K.Yang, H.Mastrogiannis, A.Rojas, K.Cervia, J. S.2026-05-19doi:10.64898/2026.05.15.26353349Cold Spring Harbor Laboratory Press2026-05-19
<![CDATA[
Variant emergence, not vaccine deployment, drives episodic positive selection on the SARS-CoV-2 spike at provincial scale in Canada
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https://www.biorxiv.org/content/10.64898/2026.05.16.725625v1?rss=1"
Tomas, M.Ndongo, C. P. K.Vilain, M.Aris-Brosou, S.2026-05-19doi:10.64898/2026.05.16.725625Cold Spring Harbor Laboratory Press2026-05-19
<![CDATA[
Orally Bioavailable SARS-CoV-2 Protease Inhibitors Bearing a Hydroxymethyl Ketone Warhead
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https://www.biorxiv.org/content/10.64898/2026.05.15.725542v1?rss=1"
Elshan, N. G. R. D.Wolff, K. C.Weiss, F.Ghorai, S.Grabovyi, G.Wilson, K.Riva, L.Woods, A. K.Pedroarena, J.Nazarian, A.Liu, Y.Mazumdar, W.Song, L.Okwor, N.Malvin, J.Bakowski, M. A.Kirkpatrick, M. G.Gebara-Lamb, A.Huang, E.Nguyen-Tran, V. T. B.Chi, V.Li, S.Lee, K.-J.McNamara, C. W.Gupta, A. K.Rahimi, A.Chen, J. J.Joseph, S. B.Schultz, P. G.Chatterjee, A. K.2026-05-18doi:10.64898/2026.05.15.725542Cold Spring Harbor Laboratory Press2026-05-18
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<![CDATA[
Environmental stochasticity can account for patterns of within-host respiratory virus evolution
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https://www.biorxiv.org/content/10.64898/2026.05.15.725410v1?rss=1"
Xiao, W. F.Farjo, M. N.Lowen, A. C.Koelle, K.2026-05-18doi:10.64898/2026.05.15.725410Cold Spring Harbor Laboratory Press2026-05-18
<![CDATA[
Who infected the reported cases? Evidence from 678,482 COVID-19 cases with identified infector collected in routine surveillance in the Netherlands, 2020-2022.
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https://www.medrxiv.org/content/10.64898/2026.05.15.26347859v1?rss=1"
Backer, J. A.Leung, K. Y.Andeweg, S. P.Van de Kassteele, J.Veldhuijzen, I.Hahne, S.Wallinga, J.2026-05-17doi:10.64898/2026.05.15.26347859Cold Spring Harbor Laboratory Press2026-05-17
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Expansion Revealing of Pathology Resolves Nanostructures Associated with Inflammatory Phenotypes in COVID-19 Decedent Human Brain Tissue
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https://www.biorxiv.org/content/10.64898/2026.05.14.725177v1?rss=1"
Stanton, A. E.Kang, J.Blanchard, J. W.Boix, C. A.Schroeder, M. E.Lee, Y.Su, H.Wang, S.Yu, E.Emenari, A.Peng, Z.Agbas, E.Cerit, O.Park, D.Zhang, R.Bennett, D. A.Yin, P.Kellis, M.Langer, R.Boyden, E.Tsai, L.-H.2026-05-15doi:10.64898/2026.05.14.725177Cold Spring Harbor Laboratory Press2026-05-15
<![CDATA[
A Structural Domain in the genomic RNA of SARS-CoV-2 Folds into a Compact Granular Structure without the N protein: A Single-Molecule Fluorescence Spectroscopic Investigation
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https://www.biorxiv.org/content/10.64898/2026.05.15.725307v1?rss=1"
Kimura, T.Katayama, T.Ishikawa, S.Mitra, S.Yamano, Y.Onizuka, K.Nagatsugi, F.Laha, S.Naganathan, A. N.Itoh, Y.Takahashi, S.2026-05-15doi:10.64898/2026.05.15.725307Cold Spring Harbor Laboratory Press2026-05-15
<![CDATA[
Immunological imprinting shapes the cross-reactive antibody responses to the KP.2 and LP.8.1 vaccine doses
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https://www.biorxiv.org/content/10.64898/2026.05.13.725047v1?rss=1"
Kumar, S.Lai, L.Ellis, M.Patel, A. B.Joshi, D. J.Velden, J. V.Faraj, J. Z. A.Wimalasena, S. T.Pallavi, R. R.Iriss, J.Bechnak, K.Edupuganti, S.Rouphael, N.Ortlund, E.Moreno, A.Menachery, V. D.Zarnitsyna, V. I.Wrammert, J.Suthar, M. S.2026-05-15doi:10.64898/2026.05.13.725047Cold Spring Harbor Laboratory Press2026-05-15
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Transcranial direct current stimulation-augmented cognitive training for post-COVID-19 cognition: A phase IIb randomized controlled trial
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https://www.medrxiv.org/content/10.64898/2026.05.11.26352906v1?rss=1"
Trujillo Llano, C.Fromm, A. E.Lingemann, L.Grittner, U.Meinzer, M. F.Fleischmann, R.Brakemeier, E.-L.Antonenko, D. F.Floeel, A.2026-05-14doi:10.64898/2026.05.11.26352906Cold Spring Harbor Laboratory Press2026-05-14
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Pathogen-specific host responses define distinct pneumonia endotypes in the human lung
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https://www.biorxiv.org/content/10.64898/2026.05.12.724509v1?rss=1"
Markov, N. S.Mozejko, M.Guggilla, V.Łazecka, M.Donnelly, H. K.Donayre, A.Fenske, S.Peltekian, A.Puczko-Szymanski, B.Szymczak, P.Izdebski, A.Luo, L.Senkow, K. J.Cusick, L.Yu, Z.Swaminathan, S.Lu, Z.Abdala-Valencia, H.Phan, D.Clepp, R. K.Rasmussen, L. V.Pawlowski, A.Pickens, C. O.Nadig, N. R.Walunas, T.Tighe, R.The Neu-Lung Investigators,Wunderink, R. G.Budinger, G. S.Morales-Nebreda, L.Gao, C. A.Singer, B. D.Misharin, A. V.Szczurek, E.The NU SCRIPT Study Investigators,2026-05-14doi:10.64898/2026.05.12.724509Cold Spring Harbor Laboratory Press2026-05-1415,000 patient-days). We used machine learning models to identify pathogen-specific host responses in the transcriptome of alveolar immune cells that were associated with changes in alveolar cell abundance and clinical features. Our results suggest that therapeutic strategies for pneumonia should be individualized to specific host-pathogen interactions.
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<![CDATA[
Independent Validation of Test-Adjusted COVID-19 Incidence Estimates Using Wastewater Surveillance Data in Ontario, Canada
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https://www.medrxiv.org/content/10.64898/2026.05.08.26352754v1?rss=1"
Fisman, D.Wilson, N.Lee, C. E.Tuite, A.2026-05-12doi:10.64898/2026.05.08.26352754Cold Spring Harbor Laboratory Press2026-05-12
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Monocyte Oxidative Stress Underlies Persistent Immune Activation in Long-COVID Postural Orthostatic Tachycardia Syndrome
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https://www.medrxiv.org/content/10.64898/2026.05.08.26352776v1?rss=1"
Mohamed, M. A.Golchha, M.Vance, Y. A.Paranjape, S. Y.Wanjalla, C.Hunter, K. C.Dikalov, S.Diedrich, A.Kulapatana, S.Mehr, P. E.Solis Montegegro, T. X.Simmons, J. D.Harrison, D. G.Shibao, C. A.2026-05-12doi:10.64898/2026.05.08.26352776Cold Spring Harbor Laboratory Press2026-05-12
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<![CDATA[
Recovery of proofreading-impaired SARS-CoV-2 reveals a mutator phenotype and an ExoN activity threshold for viability
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https://www.biorxiv.org/content/10.64898/2026.05.12.724615v1?rss=1"
He, L.Su, Y.-W. N.Zhang, F.Moustafa Abdelrady, I.Gohara, D. W.Ye, C.Martinez-Sobrido, L.Arnold, J. J.Cameron, C. E.Xiang, Y.2026-05-12doi:10.64898/2026.05.12.724615Cold Spring Harbor Laboratory Press2026-05-12
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AI-discovered protein fragments as generalizable regulators of biomolecular condensates
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https://www.biorxiv.org/content/10.64898/2026.05.08.723928v1?rss=1"
Savinov, A.Sadasivan, J.White, K. J.Rubien, J. D.Li, G.-W.Case, L. B.2026-05-12doi:10.64898/2026.05.08.723928Cold Spring Harbor Laboratory Press2026-05-12
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Crude Fucus vesiculosus fucoidan demonstrates superior SARS-CoV-2 antiviral activity compared to its pure form: binding kinetics and functional studies
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https://www.biorxiv.org/content/10.64898/2026.05.07.723385v1?rss=1"
Dudek, A.Janapatla, R. P.Chen, C. L.Chiu, C. H.2026-05-12doi:10.64898/2026.05.07.723385Cold Spring Harbor Laboratory Press2026-05-12 239 g/mL) in the pseudovirus entry assay and did not induce cytotoxicity in HEK293T cells. In conclusion, crude fucoidan with high fucose content and high molecular weight shows promising antiviral activity.
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<![CDATA[
Temperature-Dependent Replication and Sensitivity to Innate Immunity of Human Coronavirus HKU1
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https://www.biorxiv.org/content/10.64898/2026.05.07.723210v1?rss=1"
Buchrieser, J.Thuillier, E.Postal, J.Wileveau, A.Guivel-Benhassine, F.Staropoli, I.Saunders, N.Planas, D.Sugrue, J.Bondet, V.Fernandez, I.Bontems, F.Porrot, F.Petiot, C.Prot, M.Jungbauer-Groznica, M.Arowas, L.Michel, V.Blanc, C.Trouillet-Assant, S.Bruel, T.Rey, F. A.Rameix-Welti, M.-A.Casartelli, N.Fontanet, A.White, M.Duffy, D.Simon-Loriere, E.Schwartz, O.2026-05-12doi:10.64898/2026.05.07.723210Cold Spring Harbor Laboratory Press2026-05-12
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SARS CoV 2 Associated Shifts in the Upper Respiratory Tract Mycobiome in Non Hospitalized Cases
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https://www.medrxiv.org/content/10.64898/2026.05.07.26352639v1?rss=1"
Tomar, S. S.Khairnar, K.2026-05-10doi:10.64898/2026.05.07.26352639Cold Spring Harbor Laboratory Press2026-05-10
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Delayed humoral kinetics but stabilization of IgG responses in common variable immunodeficiency after SARS-CoV-2 mRNA booster vaccination
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https://www.medrxiv.org/content/10.64898/2026.05.07.26352649v1?rss=1"
Federico, L.Loeken, R. O.Quy, K. L.Osen, J. R.Chaban, V.Nordoey, I.Skarpengland, T.Lundin, K. E.Fjellgaard Joergensen, S.Fraz, M. S. A.Aukrust, P.Lund, K. P.Tran, T. T.Nygaard Osnes, L. T.Lund-Johansen, F.Kared, H.Fevang, B.Munthe, L. A.2026-05-08doi:10.64898/2026.05.07.26352649Cold Spring Harbor Laboratory Press2026-05-08
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Positive Registration Rate as a Key Determinant of COCOA Effectiveness: Empirical Evidence from Individual-Level Key-Match Data during the Sixth and Seventh COVID-19 Waves in Japan
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https://www.medrxiv.org/content/10.64898/2026.05.06.26352506v1?rss=1"
Nakagawa, S.Kumagai, S.Yamamoto, A.2026-05-08doi:10.64898/2026.05.06.26352506Cold Spring Harbor Laboratory Press2026-05-08
<![CDATA[
Safety first: should the high tolerability of intramuscular anti-spike COVID-19 monoclonal antibody change our expectations of vaccine safety?
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https://www.medrxiv.org/content/10.64898/2026.05.08.26352596v1?rss=1"
Putrino, D.Curtis, A.Leston, M.Yalcin, I.Gerlach, R.Elia, M.Mina, M.2026-05-08doi:10.64898/2026.05.08.26352596Cold Spring Harbor Laboratory Press2026-05-08
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The Effect of Vaccination on the Evolution of the SARS-CoV-2 B.1.351 Variant
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https://www.biorxiv.org/content/10.64898/2026.05.06.723356v1?rss=1"
Wang, Z.Raeihle, M.Braun-Gorman, S.Leung, I.Richards, C.Gabbay, L.Shamoon-Pour, M.2026-05-08doi:10.64898/2026.05.06.723356Cold Spring Harbor Laboratory Press2026-05-08
<![CDATA[
Site-Specific Entry Factors Define Cellular Susceptibility to SARS-CoV-2 in Human Tissues
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https://www.biorxiv.org/content/10.64898/2026.05.07.723425v1?rss=1"
Vivas-Roca, M.Mancebo-Perez, C.Abdalfttah, M.Balafkir, I.Benitez-Martinez, A.Montal, V.Gonzalez, A.Mota-Gomez, I.Grau-Exposito, J.Pieren, D. K.Planas, B.Rosado, J.Semidey, M. E.Landolfi, S.Espin-Bassany, E.Trilla, E.Falco, V.Curran, A.Burgos, J.Buzon, M. J.Guallar, V.Heyn, H.Genesca, M.2026-05-08doi:10.64898/2026.05.07.723425Cold Spring Harbor Laboratory Press2026-05-08
<![CDATA[
Helminth-remodeled microbial indole-3-lactic acid drives AhR-dependent disease tolerance
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https://www.biorxiv.org/content/10.64898/2026.05.06.723221v1?rss=1"
Sun, R.Liu, Y.Wang, Y.Xu, N.Ma, X.Lv, Q.Zhao, X.Vallee, I.Boireau, P.Wu, Z.Liu, M.Liu, X.Jin, X.2026-05-08doi:10.64898/2026.05.06.723221Cold Spring Harbor Laboratory Press2026-05-08
<![CDATA[
vartracker: an end-to-end tool for pathogen longitudinal variant analysis and visualisation
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https://www.biorxiv.org/content/10.64898/2026.05.06.723370v1?rss=1"
Foster, C. S. P.Rawlinson, W. D.2026-05-08doi:10.64898/2026.05.06.723370Cold Spring Harbor Laboratory Press2026-05-08
<![CDATA[
Determinants and long-term outcomes of COVID-19 undervaccination: a cohort study of 6.8 million individuals in Lombardy, Italy
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https://www.medrxiv.org/content/10.64898/2026.05.06.26352509v1?rss=1"
Corbetta, A.Logan, K. M.Ieva, F.Di Angelantonio, E.2026-05-07doi:10.64898/2026.05.06.26352509Cold Spring Harbor Laboratory Press2026-05-07
<![CDATA[
SARS-CoV-2 Nsp2 reprograms host immunity to drive pathogenic inflammation
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https://www.biorxiv.org/content/10.64898/2026.05.06.723222v1?rss=1"
Lacasse, E.Dubuc, I.Leclerc, J.Gravel, A.Gudimard, L.Joly-Beauparlant, C.Faure, M.Fortin, P.Blanchet, M.-R.Droit, A.Flamand, L.2026-05-07doi:10.64898/2026.05.06.723222Cold Spring Harbor Laboratory Press2026-05-07
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Functional Landscape of Motifs within the Sarbecovirus Spike Cytoplasmic Tail
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https://www.biorxiv.org/content/10.64898/2026.05.06.723231v1?rss=1"
Zhou, S.Chen, C.Liu, C.Zheng, X.Shi, L.Ma, L.Cheng, P.Wang, Q.Liu, L.2026-05-07doi:10.64898/2026.05.06.723231Cold Spring Harbor Laboratory Press2026-05-07
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The conserved QTQTX motif in the SARS-CoV-2 spike protein is dispensable for cleavage and lung cell entry of the emerging variant BA.3.2
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https://www.biorxiv.org/content/10.64898/2026.05.04.722688v1?rss=1"
Zhang, L.Chen, N.Eichmann, A.Nehlmeier, I.Hisner, R.Happle, C.Behrens, G. M. N.Hoffmann, M.Pöhlmann, S. H.2026-05-07doi:10.64898/2026.05.04.722688Cold Spring Harbor Laboratory Press2026-05-07
<![CDATA[
Inequalities in early childhood developmental concerns before, during and after the COVID-19 pandemic in Scotland: a retrospective cohort study
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https://www.medrxiv.org/content/10.64898/2026.04.30.26352025v1?rss=1"
Hardie, I.Marryat, L.Murray, A.King, J.Okelo, K.Fenton, L.Boardman, J. P.Wilson, P.Wood, R. P.Auyeung, B.2026-05-06doi:10.64898/2026.04.30.26352025Cold Spring Harbor Laboratory Press2026-05-06
<![CDATA[
Identifying the determinants of health protective behaviors during the COVID-19 pandemic using machine learning: an analysis of six countries
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https://www.medrxiv.org/content/10.64898/2026.05.05.26352439v1?rss=1"
Chevalier, J. M.Stellbrink, L. M.Steijvers, L.Wijnen, S.van Daalen, F.Kojan, L.Li, N.Jahn, B.Siebert, U.Calero Valdez, A.Hiligsmann, M.Crutzen, R.Dukers-Muijrers, N. H.Kretzschmar, M. E.2026-05-06doi:10.64898/2026.05.05.26352439Cold Spring Harbor Laboratory Press2026-05-06
<![CDATA[
Tocilizumab induces significant changes in longitudinal proteomes of blood serum from patients with severe COVID-19 pneumonia
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https://www.biorxiv.org/content/10.64898/2026.05.05.723025v1?rss=1"
Cordero, J.Bravo, G.Silva, P. H.Lozano, B.Rivas, E.Labra, V.Villalobos, D.Saldivia, P.Hernandez, M.Koch, E. S.Vargas, C.Nova-Lamperti, E.Barrera, N. P.Retamal, J.2026-05-06doi:10.64898/2026.05.05.723025Cold Spring Harbor Laboratory Press2026-05-06
<![CDATA[
Ethnic Inequalities in COVID-19 Vaccination Uptake Among Older Adults in Australia: A Nationwide Linked Data Study
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https://www.medrxiv.org/content/10.64898/2026.05.03.26351251v1?rss=1"
Xu, P.Khalatbari-Soltani, S.Sheel, M.Laaksonen, M. A.Zhu, L.Lin, Y.Abdel Shaheed, C.Sawan, M.Mussagulova, A.Gnjidic, D.Patu, P.Liu, B.Stanaway, F. F.2026-05-05doi:10.64898/2026.05.03.26351251Cold Spring Harbor Laboratory Press2026-05-05
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Early functional maturation of anti-Spike antibodies predicts SARS-CoV-2 RNA clearance in mild infection
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https://www.medrxiv.org/content/10.64898/2026.04.30.26352163v1?rss=1"
Rodrigues, D.Araujo, B.Pestana, J.da Costa, L.Andrade, M.de Freitas, L.Nery, B.Bozza, V.Conde, L.Raposo, L.Gama, A.Mendes, V.Cobos, E.Higa, L.Galliez, R.Tanuri, A.Ferreira, O.Castilho, L.Castineiras, T.Echevarria, J.Bozza, M.Vale, A. M.2026-05-03doi:10.64898/2026.04.30.26352163Cold Spring Harbor Laboratory Press2026-05-0321 days) groups. Non-persistent individuals exhibited accelerated seroconversion to Spike and receptor-binding domain (RBD) antigens during the first 11 days after symptom onset. Early antibody responses were characterized by higher functional activity, including significantly greater neutralizing activity against the ancestral strain. In contrast, persistent individuals displayed delayed seroconversion, prolonged IgM responses, and weaker coordination among IgG subclasses, with less synchronized subclass responses, during early infection. Importantly, total immunoglobulin levels did not distinguish the groups. Cross-variant antibody recognition during acute infection was limited and largely strain-focused in both groups. During convalescence, durable anti-Spike IgG responses were maintained independently of persistence status, without significant differences in cross-variant breadth. Vaccination robustly amplified antibody titers, enhanced variant recognition, and sustained high-affinity responses in both groups. Together, our findings demonstrate that the timing and functional quality of early humoral maturation, reflected by neutralizing antibody activity, rather than antibody magnitude or breadth, are key determinants of SARS-CoV-2 RNA clearance in mild infection. These results highlight the importance of early neutralizing antibody generation in shaping acute viral control and the long-term immune architecture.
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Global burden of foreign bodies and impact of COVID-19 pandemic
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https://www.medrxiv.org/content/10.64898/2026.04.29.26352072v1?rss=1"
Simayi, F.2026-04-30doi:10.64898/2026.04.29.26352072Cold Spring Harbor Laboratory Press2026-04-30
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Changing COVID-19 vaccine eligibility could reshape disease burden for all
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https://www.medrxiv.org/content/10.64898/2026.04.27.26351870v1?rss=1"
Larsen, S. L.Martinez, P. P.Mahmud, A.2026-04-29doi:10.64898/2026.04.27.26351870Cold Spring Harbor Laboratory Press2026-04-29
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Detection and characterization of single SARS-CoV-2 viral particles by flow virometry
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https://www.medrxiv.org/content/10.64898/2026.04.28.26351941v1?rss=1"
Jungbauer-Groznica, M.Commere, P.-H.Cottignies-Calamarte, A.De Cruz, A.Fantin, A.Planchais, C.Guivel-Benhassine, F.Staropoli, I.Schmutz, S.Novault, S.Veyer, D.Pere, H.Mouquet, H.Schwartz, O.Bruel, T.2026-04-29doi:10.64898/2026.04.28.26351941Cold Spring Harbor Laboratory Press2026-04-29
<![CDATA[
COVID-19 onset, stay-at-home orders, and racialized inequities in homicide mortality across the US
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https://www.medrxiv.org/content/10.64898/2026.04.28.26351994v1?rss=1"
Tanveer, M.Santaularia Gomez, N. J.Vinita Fitch, K.Holmes, M.Moracco, K. E.Dolan, M.Fulcher, N.Ranapurwala, S. I.2026-04-29doi:10.64898/2026.04.28.26351994Cold Spring Harbor Laboratory Press2026-04-29
<![CDATA[
A Deterministic-Stochastic Model for COVID-19 and Malaria Co-Infection with Malaria-Acquired Partial Immunity
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https://www.medrxiv.org/content/10.64898/2026.04.27.26351858v1?rss=1"
Idowu, K. O.Lin, G.2026-04-28doi:10.64898/2026.04.27.26351858Cold Spring Harbor Laboratory Press2026-04-28
<![CDATA[
Disentangling Fatigue from Depression among Survivors of Severe COVID-19
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https://www.medrxiv.org/content/10.64898/2026.04.24.26351694v1?rss=1"
Cabrera, J. R.Pham, P.Boscardin, W. J.Makam, A. N.2026-04-27doi:10.64898/2026.04.24.26351694Cold Spring Harbor Laboratory Press2026-04-27