Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
https://biorxiv.org
This feed contains articles for Collection "COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv"
bioRxivbioRxiv/medRxiv
https://biorxiv.org
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Host soluble inositol phosphate signaling promotes coronavirus replication
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https://www.biorxiv.org/content/10.64898/2026.09.12.751050v1?rss=1"
Shats, I.Wang, H.Zhou, Y.Gu, C.Carr, A.Guardia, C. M.Shears, S.Stanley, R. E.Zhang, Q.Blind, R.Wang, X.Li, X.2026-09-15doi:10.64898/2026.09.12.751050Cold Spring Harbor Laboratory Press2026-09-15
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A rational design strategy and validation for protease-resistant fusion-inhibitor antiviral peptides
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https://www.biorxiv.org/content/10.64898/2026.09.12.750390v1?rss=1"
Yang, K.Wang, C.Topi, F.Muratcioglu, S.Kant, R.Strandin, T.Bong, Y. T.Kareinen, L.Mäki, S.Saber, S. H.Binder, T.Sironen, T.Subramanian, S.White, K. I.Pfuetzner, R.Esquivies, L.Vapalahti, O.Joensuu, M.Kuriyan, J.Hepojoki, J.Balistreri, G.Brunger, A. T.2026-09-15doi:10.64898/2026.09.12.750390Cold Spring Harbor Laboratory Press2026-09-15
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Multi-omics reveals a monocyte-macrophage-fibroblast axis in post-COVID-19 fibroinflammatory lung remodelling
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https://www.biorxiv.org/content/10.64898/2026.09.11.750491v1?rss=1"
Mehta, P.Mawer, C. M. A.Beattie, G.Smith, D. J. F.Nikola, F.Selway-Clarke, H.Zhao, A. Y.Adams, T. S.Kunzemann-Martinez, A.Stanel, S. C.Worlock, K. B.Yoshida, M.Walters, R.Goldsworthy, S.Uddin, I.Barnes, J. L.Rockett, G. J.Nikolic, M. Z.Piazza, P.Plate, M.Stewart, I.Porter, J. C.Nair, A.Jacob, J.Yan, X.Kaminski, N.Alhendi, A. S. N.Chambers, R. C.2026-09-14doi:10.64898/2026.09.11.750491Cold Spring Harbor Laboratory Press2026-09-14
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Antibody evasion and receptor binding of SARS-CoV-2 RW.1.1
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https://www.biorxiv.org/content/10.64898/2026.09.10.750645v1?rss=1"
Daniel, K.Hong, H.Huang, C.-Y.Gordon, A.Guo, Y.Ho, D. D.Mellis, I. A.2026-09-14doi:10.64898/2026.09.10.750645Cold Spring Harbor Laboratory Press2026-09-14
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Breathlessness catastrophising after COVID-19 involves both interoceptive and visceromotor connectivity
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https://www.biorxiv.org/content/10.64898/2026.09.11.750997v1?rss=1"
Qiu, L.Raman, B.Cassar, M.Fraser, E.Atkinson, L. Z.Clare, S.Clarke, W. T.Neubauer, S.Davies, H. E.Harrison, N. A.Evans, C. J.Ezra, M.Pattinson, K. T. S.2026-09-14doi:10.64898/2026.09.11.750997Cold Spring Harbor Laboratory Press2026-09-14
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Functional plasticity of the olfactory network following functional septorhinoplasty in persistent COVID-19-related olfactory dysfunction: an fMRI study
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https://www.medrxiv.org/content/10.64898/2026.09.09.26362623v1?rss=1"
Sharma Khatiwada, A.Mancini, L.Pendolino, A. L.Gandini Wheeler-Kingshott, C. A. M.Andrews, P. J.2026-09-13doi:10.64898/2026.09.09.26362623Cold Spring Harbor Laboratory Press2026-09-13
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Hit hardest, healed least: disruption and incomplete recovery of public mental-health outpatient services across two COVID-19 waves in India, 2017-2022
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https://www.medrxiv.org/content/10.64898/2026.09.11.26362835v1?rss=1"
Mishra, V.Parihar, K. S.2026-09-13doi:10.64898/2026.09.11.26362835Cold Spring Harbor Laboratory Press2026-09-1395% of expected, mental-illness outpatient visits reached only 58.4% of expected, representing a cumulative two-year deficit of 41.6% (~5.8 million missed outpatient visits). Deficits were widespread across states. Conclusion: Public mental-health outpatient services in India were hit harder than physical-health services by the pandemic and showed essentially no post-Delta volume recovery. As India implements its national digital mental health initiative (Tele-MANAS), these data define the large, quantified outpatient deficit that digital and facility-based services must urgently address.
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ACE2 Polymorphisms rs2285666 and rs147311723 Are Clinically Relevant Variants in SARS-CoV-2 and Mycobacterium tuberculosis Co-infection.
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https://www.medrxiv.org/content/10.64898/2026.09.11.26362837v1?rss=1"
Kameni, M. N.Jean Paul, A. A.Berenger Tchoupe, E.Toyim Albert, N.Maxime Tchoutang, A.Franklin, M.Svetlana Carel, T. V.Georgette Njila, K.Neba, F. R.Donald Kamdem, S.Masumbe Netongo, P.2026-09-13doi:10.64898/2026.09.11.26362837Cold Spring Harbor Laboratory Press2026-09-13
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Healthy vaccinee effect in SARS-CoV-2 vaccinees without documented infection
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https://www.medrxiv.org/content/10.64898/2026.09.04.26362245v1?rss=1"
Riedmann, U.Brenner, H.Ioannidis, J.Pilz, S.2026-09-11doi:10.64898/2026.09.04.26362245Cold Spring Harbor Laboratory Press2026-09-11
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Longitudinal antibody correlates of SARS-CoV-2 infection in a US household cohort during Omicron waves
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https://www.medrxiv.org/content/10.64898/2026.09.10.26362752v1?rss=1"
Yang, Y.Callear, A.Smith, M.Juntila-Raymond, C.Godonou, E.-T.Johnson, E.Lauring, A. S.Fitzsimmons, W. J.Jones, J. M.Midgley, C. M.Monto, A. S.Martin, E. T.2026-09-11doi:10.64898/2026.09.10.26362752Cold Spring Harbor Laboratory Press2026-09-11
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Real-time accessible phylogenetics for every highly sampled virus
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https://www.biorxiv.org/content/10.64898/2026.09.10.750728v1?rss=1"
Hinrichs, A. S.Karim, L. M.Turakhia, Y.Sanderson, T.Corbett-Detig, R.2026-09-11doi:10.64898/2026.09.10.750728Cold Spring Harbor Laboratory Press2026-09-11
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Hantavirus mutagenesis is impacted by mutagens and host antiviral proteins
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https://www.biorxiv.org/content/10.64898/2026.09.10.750593v1?rss=1"
Ruis, C.Parkhill, J.Floto, R. A.2026-09-11doi:10.64898/2026.09.10.750593Cold Spring Harbor Laboratory Press2026-09-11
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A comparison of two forecasting models for COVID-19 hospitalizations using wastewater concentration data
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https://www.medrxiv.org/content/10.64898/2026.09.08.26362558v1?rss=1"
Keyel, A.Hill, D. T.Johnson, K. E.Lang, D.Rosenberg, E. S.Bush, K.Larsen, D. A.2026-09-10doi:10.64898/2026.09.08.26362558Cold Spring Harbor Laboratory Press2026-09-10
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Mental health before, during, and after COVID-19 (through 2025) in boys, girls, and gender-diverse youth
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https://www.medrxiv.org/content/10.64898/2026.09.06.26362161v1?rss=1"
Kiviruusu, O.Therman, S.Lehtonen, J.Ystrom, E.Butwicka, A.Halldorsdottir, T.Ask, H.Suvisaari, J.2026-09-10doi:10.64898/2026.09.06.26362161Cold Spring Harbor Laboratory Press2026-09-10
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Pre-Infection Mental Health, but Not Brain Volumetry, Predicts Risk of Post-COVID Condition: A Population-Based Cohort Study in the German National Cohort (NAKO)
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https://www.medrxiv.org/content/10.64898/2026.09.09.26362611v1?rss=1"
Flint, C.Spreckelsen, C.Otto, C.Mikolajczyk, R.Frost, J.Claass, L. V.Fasshauer, J. M.Scholz, M.Buschmann, L.Rübsamen, N.Wright, M. N.Burk, L.Bamberg, F.Schlett, C. L.Niendorf, T.Forsting, M.Li, Y.Steindorf, K.Karrasch, S.Leitzmann, M.Haug, S.Bärnighausen, T. W.Schmidt, B.Harries, M.Melhorn, V.Krist, L.Keil, T.Peters, A.Opel, N.2026-09-10doi:10.64898/2026.09.09.26362611Cold Spring Harbor Laboratory Press2026-09-10 10.75) and the rest were symptom-free controls, ten pre-infection modalities (T1-weighted volumetric brain MRI across six parcellations, baseline mental health (PHQ-9, GAD-7), demographics, and seven further biomedical and socioeconomic domains) entered a stacked ensemble with 10x5 nested cross-validation (primary metric: the area under the precision-recall curve, PR-AUC). Pre-specified analyses assessed transportability to a non-imaging cohort and robustness to symptom trajectory and unmeasured confounding. SARS-CoV-2 infection status and the PCC outcome were ascertained by self-report; no clinically confirmed diagnoses were available.
ResultsBaseline mental health, assessed 3-8 years before infection, was the strongest predictor (38.2% of feature importance; standalone ROC-AUC = 0.640), whereas all six brain-MRI parcellations performed at or near chance (ROC-AUC 0.496-0.516). The multi-modal model achieved moderate, well-calibrated discrimination (ROC-AUC = 0.664, 95% CI 0.652-0.677; PR-AUC = 0.413, 0.392-0.434; ECE = 0.015). Applied without retraining to the non-imaging cohort it retained discrimination (ROC-AUC = 0.660, 0.654-0.665), meeting two of three pre-specified equivalence criteria. Adjusting for the full symptom trajectory shrank the base-line mental-health odds ratio from 2.06 (1.83-2.32) to a conservative lower bound of 1.38 (1.20-1.58; E-value 2.66) while leaving it independently significant, and was essentially unchanged under an alternative control definition (2.07). Baseline mental health did not predict objectively measured hyposmia in participants screened before their infection (0.89) while predicting self-reported smell loss in the same participants (1.92).
ConclusionsBaseline mental health years before infection is the strongest pre-infection predictor of PCC among the infected, and the association held across the pre-specified sensitivity analyses. Whether it acts specifically on COVID-19 sequelae is a separate question this design cannot answer, and the indirect evidence points away from specificity: the association is undiminished after mild infection but absent among the hospitalised, and baseline mental health predicts current symptom load no more strongly in infected than in non-infected participants. The volumetric structural candidate is not supported: pre-pandemic T1-weighted volumetry carried no predictive signal in this single neuroimaging cohort, consistent with COVID-19-associated brain changes being acute-onset rather than pre-existing. Risk stratification may benefit from incorporating baseline psychiatric phenotype; whether treating it reduces PCC incidence requires interventional study.
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Clinico-Epidemiological Characteristics, Hospital Care Interventions, and Clinical Outcomes of Patients with SARS-CoV-2 in Nepal: The Mediating Role of Age
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https://www.medrxiv.org/content/10.64898/2026.09.08.26362589v1?rss=1"
Neupane, M. S.Hassan, H. C.Uranw, S.Mehta, R. K.2026-09-10doi:10.64898/2026.09.08.26362589Cold Spring Harbor Laboratory Press2026-09-10
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Risk of acute gastroenteritis following COVID-19 exposure: a retrospective population-based analysis conducted in England
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https://www.medrxiv.org/content/10.64898/2026.09.07.26362439v1?rss=1"
Hawkings, M. J.Hughes, D. M.Elliot, A. J.Buchan, I. E.Hungerford, D.2026-09-09doi:10.64898/2026.09.07.26362439Cold Spring Harbor Laboratory Press2026-09-09
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PhenoMapR: scalable mapping of sample phenotypes to single-cell, spatial, and bulk transcriptomics data
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https://www.biorxiv.org/content/10.64898/2026.09.08.749933v1?rss=1"
Benard, B. A.Lalgudi, C. K.Azizi, A.Gentles, A. J.2026-09-09doi:10.64898/2026.09.08.749933Cold Spring Harbor Laboratory Press2026-09-09
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The impact of COVID-19 pandemic on health service utilization among patients with chronic non-communicable diseases in Ghana
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https://www.medrxiv.org/content/10.64898/2026.09.03.26362130v1?rss=1"
Tannor, E. K.Newton, S.Busse, R.Gatorwu, S.Safo, J. K.Adjei, R.Amuasi, J.Quentin, W.2026-09-08doi:10.64898/2026.09.03.26362130Cold Spring Harbor Laboratory Press2026-09-08
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Early human capital, the COVID-19 food-insecurity shock, and adult mental health: a 22-year cohort study in Ethiopia, India, and Peru
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https://www.medrxiv.org/content/10.64898/2026.09.02.26362122v1?rss=1"
Diaz Flores, M. A.Jimenez Rivera, W. M.Pena Huaman, G. M.Romero Molina, U.2026-09-08doi:10.64898/2026.09.02.26362122Cold Spring Harbor Laboratory Press2026-09-08
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Association between ABO Blood Group and COVID-19 Pneumonia Severity: A Cross-Sectional Study from Ethiopia's First Designated COVID-19 Treatment Center
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https://www.medrxiv.org/content/10.64898/2026.09.04.26362275v1?rss=1"
Urgecha, E. B.Tefera, F. A.Alemu, Z. A.Mekonen, S. T.Orgecha, E. B.Gidey, S. N.Fissehatsion, F. A.2026-09-08doi:10.64898/2026.09.04.26362275Cold Spring Harbor Laboratory Press2026-09-08
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Aggregation of mortality data by place and cause mask underlying trends in COVID-19 excess mortality
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https://www.medrxiv.org/content/10.64898/2026.09.04.26362260v1?rss=1"
Herdzik, K.Sakrejda, K.Wagner, A.Zelner, J.2026-09-08doi:10.64898/2026.09.04.26362260Cold Spring Harbor Laboratory Press2026-09-08
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Using large language models to facilitate literature review and data extraction for infectious disease models: COVID-19 as a test case
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https://www.medrxiv.org/content/10.64898/2026.09.06.26362399v1?rss=1"
Yang, X.Lee, C. Y.Quilty, B. J.Zhang, L.Mu, Y.Jit, M.2026-09-08doi:10.64898/2026.09.06.26362399Cold Spring Harbor Laboratory Press2026-09-08
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Ensemble SHAP Aggregation and Attribution Variability in Clinical Machine Learning: A COVID-19 Mortality Study
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https://www.medrxiv.org/content/10.64898/2026.09.07.26362459v1?rss=1"
Dai, N.Briceno, R. K.Castaneda, A. N.Tresierra, M. A.Esteban, M. L.Rosas, M. E.Hinojosa, R. C.2026-09-08doi:10.64898/2026.09.07.26362459Cold Spring Harbor Laboratory Press2026-09-08
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Neural characterisation of persistent quantitative and qualitative COVID-19-related olfactory dysfunction: The COVORTS study
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https://www.medrxiv.org/content/10.64898/2026.09.07.26362431v1?rss=1"
Dijk, B. v.Postma, E. M.Leenders, L. M.Smits, P.Kamalski, D. M. A.Smeets, P. A. M.Boesveldt, S.2026-09-08doi:10.64898/2026.09.07.26362431Cold Spring Harbor Laboratory Press2026-09-08 1 month) quantitative OD (Sniffin Sticks score < 30.75, n=21) or parosmia (self-reported, n=27) following SARS-CoV-2 infection, aged 19-60 years and, on average, included 472 days after diagnosis (the COVORTS study). Additionally, a control group of 49 normosmic subjects aged 22-60 years was included. Olfactory bulb volume (OBV) was determined by manual segmentation; whole-brain and regional grey matter density (GMD) of olfactory-related areas was assessed using voxel-based morphometry; and odour-induced brain activation was examined with an olfactory fMRI task. When grouped together, patients with OD had a smaller OBV than controls (84.4 vs 95.3 mm3, p=0.026). The two patient groups did not differ in OBV. ROI analysis of olfactory-related brain regions at an exploratory threshold showed lower GMD in primary and secondary olfactory regions in patients compared to controls, which appears to be mainly driven by quantitative OD. No difference in odour-induced brain activation was found. The observed smaller olfactory bulbs, along with modest findings beyond this primary olfactory structure, provide important insights into potential mechanisms of persistent COVID-19-related OD and highlight the need for longer follow-up to evaluate further neural degradation or recovery.
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Clinical Phenotypes of Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection: A Longitudinal Cohort Study from Karachi, Pakistan
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https://www.medrxiv.org/content/10.64898/2026.09.04.26361413v1?rss=1"
Khanum, I.Ahmed, K.Munir, T.Zia, H.Saif, W.Sadia, H.Mahmood, S. F.Nasir, N.Ghias, K.Rabinowitz, P.Van Voorhis, W.Iqbal, N. T. T.2026-09-08doi:10.64898/2026.09.04.26361413Cold Spring Harbor Laboratory Press2026-09-08
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The COVID-19 Trajectory in Israel: A Comprehensive Analysis of National Surveillance Data on Documented Infections, Test Positivity, and Vaccine-Effectiveness Estimates
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https://www.medrxiv.org/content/10.64898/2026.09.06.26362366v1?rss=1"
Ophir, Y.Sevillya, G.2026-09-08doi:10.64898/2026.09.06.26362366Cold Spring Harbor Laboratory Press2026-09-08
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Allosteric remodelling of the Ebola virus glycoprotein underlies differences in entry mechanisms across species
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https://www.biorxiv.org/content/10.64898/2026.09.04.749277v1?rss=1"
Calvaresi, V.Kratochvil, J.Bekauri, A.Kukura, P.Struwe, W. B.2026-09-08doi:10.64898/2026.09.04.749277Cold Spring Harbor Laboratory Press2026-09-08
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Variant-specific nucleocapsid mutations shape host innate immune trajectories during SARS-CoV-2 infection
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https://www.biorxiv.org/content/10.64898/2026.09.03.749134v1?rss=1"
Berger, J. M.Schroeder, J. M.Soh, T. K.Pekarek, N.Breul, L.-M.Doerner, S.Bluemke, P.Huang, J.Bosse, J. B.Pfefferle, S.Uetrecht, C.2026-09-08doi:10.64898/2026.09.03.749134Cold Spring Harbor Laboratory Press2026-09-08
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MutCleaner: Cleaning and Standardizing Biological Mutation Datasets for Variant Effect Prediction
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https://www.biorxiv.org/content/10.64898/2026.09.06.749687v1?rss=1"
Shi, Z.Tang, Y.Yang, M.Yu, S.Shi, Y.Xu, Y.2026-09-08doi:10.64898/2026.09.06.749687Cold Spring Harbor Laboratory Press2026-09-08
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Experimental validation of computationally prioritized bisphosphonates reveals no direct in vitro antiviral activity against SARS-CoV-2
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https://www.biorxiv.org/content/10.64898/2026.09.07.749793v1?rss=1"
Rehman, M. M.-U.-Olliff, S.McAuley, A.Awasthi, A.Chandrasekhar, K. V. G.Sankranarayanan, M.Vasan, S. S.2026-09-08doi:10.64898/2026.09.07.749793Cold Spring Harbor Laboratory Press2026-09-08
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Ebola virus mRNAs contain RNA structures that are critical for viral infection and targetable by antisense oligonucleotides
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https://www.biorxiv.org/content/10.64898/2026.09.04.749507v1?rss=1"
Luo, M.Olejnik, J.Meier, K.Hann, T.Muhlberger, E.Pyle, A. M.2026-09-08doi:10.64898/2026.09.04.749507Cold Spring Harbor Laboratory Press2026-09-0860%, indicating these mRNA structures are critical for infection. LNA targeting of the newly identified structures reduced EBOV infection by 31% to 88%, thereby linking RNA structural integrity to viral function. Synonymous mutation rates and covariation analysis provided evolutionary support across mammalian filoviruses for the functional RNA elements observed. Collectively, these results demonstrate EBOV mRNAs contain numerous conserved RNA motifs contributing to viral infection, and that these elements represent promising targets for development of pan-filoviral therapeutics.
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Increased receptor binding capability of the SARS-CoV-2 saltational variant PJ.2.1
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https://www.biorxiv.org/content/10.64898/2026.09.03.749172v1?rss=1"
He, P.Li, B.Guo, C.Yu, L.Yu, Y.Jian, F.Shao, F.Cao, Y.2026-09-08doi:10.64898/2026.09.03.749172Cold Spring Harbor Laboratory Press2026-09-08
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Interferon redundancy counteracts proteolytic inactivation by SARS-CoV-2 3CL main protease
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https://www.biorxiv.org/content/10.64898/2026.09.07.749787v1?rss=1"
Grin, P. M.de Jesus, H. C. R.Pablos, I.Kappelhoff, R.Butler, G. S.Charaf, B.Overall, C. M.2026-09-08doi:10.64898/2026.09.07.749787Cold Spring Harbor Laboratory Press2026-09-08
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Laemple: A Benchmarking Framework for Virus Lineage Deconvolution Tools for SARS-CoV-2 from Wastewater
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https://www.medrxiv.org/content/10.64898/2026.09.02.26362081v1?rss=1"
Schedl, A.Bergthaler, A.Amman, F.2026-09-07doi:10.64898/2026.09.02.26362081Cold Spring Harbor Laboratory Press2026-09-07
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Allergic airway inflammation protects against SARS-CoV-2 and MERS-CoV disease but promotes fatal SARS-CoV-1 immunopathology
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https://www.biorxiv.org/content/10.64898/2026.09.02.748812v1?rss=1"
Ardanuy, J.Garrett, G.Dillen, C.Liu, M.Taylor, L.Keegan, A.Diamond, M.Frieman, M.2026-09-07doi:10.64898/2026.09.02.748812Cold Spring Harbor Laboratory Press2026-09-07
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Surgical Critical Care Outcomes Before and After the Onset of the COVID-19 Pandemic: A Single-Center Retrospective Comparative Audit
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https://www.medrxiv.org/content/10.64898/2026.09.02.26361948v1?rss=1"
Ali, S. M. H.Yasin, U.Ather, O.Malik, A.2026-09-06doi:10.64898/2026.09.02.26361948Cold Spring Harbor Laboratory Press2026-09-06
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The orphan receptor IL-17RD is a negative regulator of RIG-I-like receptor-dependent antiviral innate immunity and restrains SARS-CoV-2-induced lung inflammation
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https://www.biorxiv.org/content/10.64898/2026.09.01.747870v1?rss=1"
El-Mortada, F.Roy, J.Girondel, C.Do, F.Dos Santos Pereira Andrade, A. C.Lacasse, E.Dubuc, I.Roux, P. P.St-Jean, G.Demey, B.Labrecque, N.Flamand, L.Meloche, S.Servant, M. J.2026-09-03doi:10.64898/2026.09.01.747870Cold Spring Harbor Laboratory Press2026-09-03
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Identification of a SARS-CoV-2 Spike RNA-Cleaving DNAzyme and Optimization of Its AS1411 Chimera
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https://www.biorxiv.org/content/10.64898/2026.09.01.748480v1?rss=1"
Unlu, Z. B.Portakal, H. S.Doluca, O.2026-09-03doi:10.64898/2026.09.01.748480Cold Spring Harbor Laboratory Press2026-09-03
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Multivalent Anti-ACE2 Nanobodies Confer Broad Pan-Sarbecovirus Protection
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https://www.biorxiv.org/content/10.64898/2026.09.01.748598v1?rss=1"
Bakasis, A. D.Patejak, R.Fridy, P. C.Jenkins, J.Aldis, M.Baharani, V. A.Sriram, L.Molloy, K. R.Chait, B. T.Rout, M. P.Cross, F. R.Bieniasz, P. D.Hatziioannou, T.2026-09-03doi:10.64898/2026.09.01.748598Cold Spring Harbor Laboratory Press2026-09-03
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Prevalence and Functional Outcomes of Post-Exertional Malaise among Adults with prior COVID-19: Results from a Representative Survey of New York City Residents
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https://www.medrxiv.org/content/10.64898/2026.08.31.26356614v1?rss=1"
Packard, S. E.Russo, T.Parrott, J.Sisti, J.Lans, A.2026-09-02doi:10.64898/2026.08.31.26356614Cold Spring Harbor Laboratory Press2026-09-02
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Impaired memory B-cell formation after mRNA-based COVID-19 booster vaccination in patients with inflammatory bowel disease receiving anti-TNF treatment
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https://www.medrxiv.org/content/10.64898/2026.08.28.26359302v1?rss=1"
Gill, P. A.Bradbury, L. R.Wang, A.Hogg, J.Demase, K.McKenzie, J.Fryer, H. A.Geers, D.Zaeck, L. M.Boo, I.Hogarth, M. P.Drummer, H. E.de Vries, R. D.O'Hehir, R. E.Sparrow, M. P.van Zelm, M. C.2026-09-02doi:10.64898/2026.08.28.26359302Cold Spring Harbor Laboratory Press2026-09-02
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Predicting COVID-19 hospitalisation and common disease risk from comorbid diagnoses in 13 million individuals
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https://www.medrxiv.org/content/10.64898/2026.08.27.26361302v1?rss=1"
Liu, H.Mizani, M. A.Zhao, Y.Wood, A.Inouye, M.Price, A. L.Jiang, X.CVD-COVID-UK/COVID-IMPACT Consortium,2026-09-01doi:10.64898/2026.08.27.26361302Cold Spring Harbor Laboratory Press2026-09-01
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Mind the gap between functional groups and surface of magnetic nanoparticles for highly specific magnetic-based protein assays in biological medium
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https://www.biorxiv.org/content/10.64898/2026.08.29.747976v1?rss=1"
Amin, R.Wang, Y.Wolgast, F.Chowdhury, M. S.Lehmler, N.Schubert, M.Schilling, M.Viereck, T.Lak, A.2026-09-01doi:10.64898/2026.08.29.747976Cold Spring Harbor Laboratory Press2026-09-01
<![CDATA[
Structure-inspired design of Nsp8-based protein inhibitors to suppress SARS-CoV-2 replication
]]>
https://www.biorxiv.org/content/10.64898/2026.08.30.747997v1?rss=1"
Sterbova, P.Lin, H. H.Tu, I.-P.Chang, W.-h.2026-09-01doi:10.64898/2026.08.30.747997Cold Spring Harbor Laboratory Press2026-09-01
<![CDATA[
Widespread SARS-CoV-2 infection in free-ranging Neotropical bats suggests repeated human-to-bat spillback
]]>
https://www.biorxiv.org/content/10.64898/2026.08.27.741511v1?rss=1"
Armijos-Rivera, J.Parra, G.Bravo-Bonilla, M.Gonzalez-Maldonado, M.Roman-Caceres, D.Vasquez-Tituana, A.Valdivieso, J.Tinoco, F.Villavicencio, A.Aguirre, N.Cisneros-Vidal, R.Romero, V.Garces, J.de Mora, D.Bruno, A.Moreno, A.Tolini, C.Bavagnoli, L.Gomulski, L. M.Scolari, F.Crespan, E.2026-09-01doi:10.64898/2026.08.27.741511Cold Spring Harbor Laboratory Press2026-09-0199% nucleotide identity to contemporary human SARS-CoV-2 lineages and clustered within multiple global phylogenetic clades. Mixed-effects modeling revealed pronounced species-level heterogeneity, a positive association between elevation and infection probability, and higher infection probability in females compared with males. The close phylogenetic affinity of bat-derived genomes to circulating human variants and their distribution across multiple lineages suggest repeated anthropogenic spillback rather than sustained bat-specific circulation. These results expand current understanding of the ecological footprint of the COVID-19 pandemic and highlight the importance of integrating wildlife surveillance into long-term One Health strategies for emerging infectious diseases.
]]>
<![CDATA[
Identification of a pan-orthoebolavirus-reactive antibody from an rVSV-EBOV vaccinated individual
]]>
https://www.biorxiv.org/content/10.64898/2026.08.28.747769v1?rss=1"
Tarnow, P.Cohen-Dvashi, H.Rohde, C.Kraehling, V.Ullrich, L.Gieselmann, L.Zar Shuker, H.Amatya, S.Fathi, A.Kupke, A.Kreer, C.BSL-4 Animal Facility Team,Koch, M.Addo, M. M.Becker, S.Diskin, R.Zehner, M.Klein, F.2026-09-01doi:10.64898/2026.08.28.747769Cold Spring Harbor Laboratory Press2026-09-01
<![CDATA[
Clinical features of COVID-19 patients hospitalized at the Tashkent State Medical University and risk factors for intensive care unit admission: a cross-sectional study from Uzbekistan, Central Asia
]]>
https://www.medrxiv.org/content/10.64898/2026.08.28.26361631v1?rss=1"
Rakhimov, B.Choi, J.Kim, K.Tuychiev, L.Shadmanov, A.Mamatkulov, B.2026-08-31doi:10.64898/2026.08.28.26361631Cold Spring Harbor Laboratory Press2026-08-31
<![CDATA[
A Multivariable Plasma Extracellular Vesicle Surface Profile Associated with Post-COVID-19 Syndrome
]]>
https://www.medrxiv.org/content/10.64898/2026.08.27.26361498v1?rss=1"
Erhart, D. K.Ressin, H.Balz, L. T.Chatterjee, S.Lule, D.Mueller, S.Lewerenz, J.Muench, J.Tumani, H.Gross, R. M.2026-08-31doi:10.64898/2026.08.27.26361498Cold Spring Harbor Laboratory Press2026-08-31
<![CDATA[
Acute Protein Responses Control SARS-CoV-2-specific Neurocognitive and General Post-Viral Sequelae
]]>
https://www.medrxiv.org/content/10.64898/2026.08.27.26361488v1?rss=1"
Liou, T. G.Andrews, R. J.Bass, B. L.Battey, H.Buonfiglio, L. G. V.Cahill, B. C.Cox, J. E.Gibson, S.Hartsell, S. C.Hatton, N.Hazel, M.Helms, M. N.Jensen, J. L.Kartsonaki, C.Kupfer, J.Li, Y.Lopes, F. B. T. P.Manuel, A.Marchetti, M.Marvin, J. E.Middleton, E. A.Mimche, P.Packer, K. A.Paine, R.Szczesniak, R. D.Sturrock, A. B.Tandar, A.Tarbet, B.Ulrich, A.Warner, D.Warren, K.Weis, A. M.Zimmerman, E.Yoon, S.Ownbey, M.Youngquist, S. T.Adler, F. R.2026-08-31doi:10.64898/2026.08.27.26361488Cold Spring Harbor Laboratory Press2026-08-31
<![CDATA[
Understanding RSV Resurgence Following COVID-19 in Ontario, Canada: Evaluating the Roles of Contact Patterns and Maternal Immunity
]]>
https://www.medrxiv.org/content/10.64898/2026.08.28.26361657v1?rss=1"
Parpia, A.Wright, J.Gharouni, A.Thampi, N.Fitzpatrick, T.2026-08-31doi:10.64898/2026.08.28.26361657Cold Spring Harbor Laboratory Press2026-08-31
<![CDATA[
Rural-urban disparities and associated factors of SARS-CoV-2 infection in Zambia: A convergent mixed-methods study using the Proximate Determinant Framework.
]]>
https://www.medrxiv.org/content/10.64898/2026.08.25.26361355v1?rss=1"
Wantakisha, E. W. R.Nyirenda, S.Narayani, M.2026-08-31doi:10.64898/2026.08.25.26361355Cold Spring Harbor Laboratory Press2026-08-31
<![CDATA[
Temporal inequalities in the global COVID-19 vaccine rollout: a cross-national observational study of delivery, health-system capacity, and time to coverage
]]>
https://www.medrxiv.org/content/10.64898/2026.08.29.26361724v1?rss=1"
Lee, H.-W.Huang, Y.-H.McAndrew, T. C.2026-08-31doi:10.64898/2026.08.29.26361724Cold Spring Harbor Laboratory Press2026-08-31
<![CDATA[
Mucosal vaccine-elicited IgA is protective against zoonotic Betacoronavirus challenge
]]>
https://www.biorxiv.org/content/10.64898/2026.08.26.747300v1?rss=1"
Seo, J.Buck, E.Machani, B.Murillo, O.Maharjan, B.Filler, R.Saunders, K. O.Wilen, C.Israelow, B.Martinez, D. R.2026-08-28doi:10.64898/2026.08.26.747300Cold Spring Harbor Laboratory Press2026-08-28
<![CDATA[
Defining Operational UV-C Dose Requirements for Autonomous Disinfection of Clinically Relevant Pathogens Across Healthcare and High-Touch Surfaces
]]>
https://www.biorxiv.org/content/10.64898/2026.08.24.746724v1?rss=1"
Wu, I. K. F.Vajaria, N. R.Viruega, L. V. S.Wisebourt, E.Solis-Reyes, P. F.Ryu, K.Ilasin, E. R.Shi, A. Y.Friesen, N. J.Fariha, K. A.Barr, S. D.2026-08-27doi:10.64898/2026.08.24.746724Cold Spring Harbor Laboratory Press2026-08-27
<![CDATA[
HIDE-Deconv: A hierarchical deconvolution framework for multiscale characterization of cellular remodeling
]]>
https://www.biorxiv.org/content/10.64898/2026.08.24.746754v1?rss=1"
Goertler, F.Voelkl, D.Bolz, S.Rayford, A.Stevenson, T.Sterr, T.Mensching-Buhr, M.Seifert, N.Altenbuchinger, M.Arp, J.Schuster, C.Tausche, J.Engel, L.Zacharias, H. U.2026-08-26doi:10.64898/2026.08.24.746754Cold Spring Harbor Laboratory Press2026-08-26
<![CDATA[
Tree-aware conditional language modeling recovers mutational patterns of viral evolution
]]>
https://www.biorxiv.org/content/10.64898/2026.08.25.746971v1?rss=1"
Polunina, P. V.Maier, W.Rubin, A. F.2026-08-26doi:10.64898/2026.08.25.746971Cold Spring Harbor Laboratory Press2026-08-26
<![CDATA[
A rapidly deployable CRISPR-Cas3 diagnostic platform for emerging RNA viruses
]]>
https://www.biorxiv.org/content/10.64898/2026.08.25.746999v1?rss=1"
Nakamura, J.Miyazaki, K.Torii, S.Kitajima, M.Mikamo, K.Kimihira, T.Morimoto, L.Ashayqa, H.Ito, J.Takeshita, K.Kosugi, S.Minegishi, Y.Ito, M.Hirano, R.Ishida, S.Yoshimi, K.Halfmann, P. J.Kawaoka, Y.Mashimo, T.2026-08-26doi:10.64898/2026.08.25.746999Cold Spring Harbor Laboratory Press2026-08-26
<![CDATA[
A Medicinal Chemistry-Centered Evaluation of AlphaFold 3 and Boltz-2 Across Diverse Binding Modalities
]]>
https://www.biorxiv.org/content/10.64898/2026.08.24.746785v1?rss=1"
Chen, K.Qi, Z.Lozano Ramos, O.Li, H.Ma, M.Gannarapu, M. R.Bi, F.Li, A.Li, H.XIONG, R.2026-08-26doi:10.64898/2026.08.24.746785Cold Spring Harbor Laboratory Press2026-08-26
<![CDATA[
CAPRIN1 localizes to CD63-positive MVB-like SARS-CoV-2 egress compartments and limits cytopathic effects
]]>
https://www.biorxiv.org/content/10.64898/2026.08.25.746949v1?rss=1"
Woloszyn, J. S.Schroeder, J.Berger, J. M.Kotova, E.Schaeper, R.Pfefferle, S.Uetrecht, C.Soh, T. K.Bosse, J. B.2026-08-26doi:10.64898/2026.08.25.746949Cold Spring Harbor Laboratory Press2026-08-26
<![CDATA[
A Selenium-Deficient Mouse Model of Mouse-Adapted SARS-CoV-2 Demonstrates Variant Emergence Observed in SARS-CoV-2 Pandemic Variants
]]>
https://www.biorxiv.org/content/10.64898/2026.08.25.746963v1?rss=1"
Graham, M. E.Oluwasemowo, O.Murugesh, D. K.Rangel, M. V.Kimbrel, J. A.Avila-Herrera, A.Thiessen, J.Zemla, A.Phillips, A. M.Collette, N.Weilhammer, D.Borucki, M. K.2026-08-26doi:10.64898/2026.08.25.746963Cold Spring Harbor Laboratory Press2026-08-26
<![CDATA[
rVSV-EBOV vaccination protects ferrets from lethal Bundibugyo virus disease
]]>
https://www.biorxiv.org/content/10.64898/2026.08.24.746878v1?rss=1"
Wight, J.Liu, G.Chan, M.Medina, S. J.Lu, D.Cao, W.Krosta, S. J.Tierney, K.Azaransky, K.Banadyga, L.2026-08-26doi:10.64898/2026.08.24.746878Cold Spring Harbor Laboratory Press2026-08-26
<![CDATA[
Microenvironment-informed inference of transcriptional progression geometry
]]>
https://www.biorxiv.org/content/10.64898/2026.08.21.746284v1?rss=1"
Kobara, S.Rahman, S. A.Ribeiro, S. P.Coopersmith, C. M.Kamaleswaran, R.2026-08-24doi:10.64898/2026.08.21.746284Cold Spring Harbor Laboratory Press2026-08-24
<![CDATA[
Scarless SARS-CoV-2 Genome Engineering and Variant Analysis
]]>
https://www.biorxiv.org/content/10.64898/2026.08.21.746147v1?rss=1"
Dabrowska, A.Cuell, A.Basu, R.Vishwakarma, J.Delgado, R.Barreto Duran, E.Liu, X.He, L.Xiang, Y.Ye, C.Martinez-Sobrido, L.Harris, R. S.2026-08-24doi:10.64898/2026.08.21.746147Cold Spring Harbor Laboratory Press2026-08-24
<![CDATA[
Pathogenesis and natural history of the Bundibugyo species of Orthoebolavirus in nonhuman primates
]]>
https://www.biorxiv.org/content/10.64898/2026.08.10.743937v1?rss=1"
Fenton, K.Pigeaud, D.Turcinovic, J.Prasad, A.Agans, K.Dobias, N.O'Toole, R.Lona, A.Woolsey, C.Borisevich, V.Deer, D.Geisbert, J.Basler, C.Cross, R. W.Geisbert, T.2026-08-12doi:10.64898/2026.08.10.743937Cold Spring Harbor Laboratory Press2026-08-12
<![CDATA[
Engineering growth-coupled metabolic biosensors for disease prognosis and diagnosis using full growth trajectories
]]>
https://www.biorxiv.org/content/10.64898/2026.08.04.740108v1?rss=1"
Ahavi, P.Hoang, T.-N.-A.Meyer, P.Epaulard, O.Le Gouellec, A.Faulon, J.-L.2026-08-12doi:10.64898/2026.08.04.740108Cold Spring Harbor Laboratory Press2026-08-12
<![CDATA[
SARS-CoV-2 ORF8 modulates the upper respiratory tract inflammatory response to facilitate transmission
]]>
https://www.biorxiv.org/content/10.64898/2026.08.09.743817v1?rss=1"
Ciabattoni, G. O.Bartlett, S.McGrath, M. E.Frieman, M. B.Dittmann, M.Ortigoza, M. B.2026-08-11doi:10.64898/2026.08.09.743817Cold Spring Harbor Laboratory Press2026-08-11
<![CDATA[
A Time-Resolved Single-Cell Atlas Reveals Infection-Status, Age-, and Sex-Dependent Immune Responses Drive Viral Disease Severity
]]>
https://www.biorxiv.org/content/10.64898/2026.08.10.744019v1?rss=1"
Chen, L.Qiu, A.Kim, J.Abu Hussein, N.Lu, M.Agaronyan, K.Sun, K.Yuan, Y.Zhao, A.Heda, G.Lu, X.Kitsios, G.Rizzo, A. N.Bain, W.Nyunoya, T.Suber, T.Evankovich, J.Shah, F.Dela Cruz, C. S.Manning, E.Sharma, L.2026-08-11doi:10.64898/2026.08.10.744019Cold Spring Harbor Laboratory Press2026-08-11
<![CDATA[
RheoScale 2.0: Revealing the Hidden Roles of Protein Positions via Substitution Patterns
]]>
https://www.biorxiv.org/content/10.64898/2026.08.10.743964v1?rss=1"
Liu, D.Sreenivasan, S.Gray, C. J.Cleveland, H. C.Swint-Kruse, L.2026-08-11doi:10.64898/2026.08.10.743964Cold Spring Harbor Laboratory Press2026-08-11
<![CDATA[
LC3C-ATG4D regulatory axis supports coronavirus replication organelle formation independently of canonical autophagy
]]>
https://www.biorxiv.org/content/10.64898/2026.08.10.743971v1?rss=1"
Vlachova, S.Iovine, L.Marano, V.Polishchuk, E.Cillo, M.Donnici, L.Machado, P.Swuec, P.Settembre, C.Grumati, P.De Francesco, R.Herhaus, L.Cortese, M.2026-08-11doi:10.64898/2026.08.10.743971Cold Spring Harbor Laboratory Press2026-08-11
<![CDATA[
Multiomic and Spatial Profiling of Colorectal Tissue Reveals Viral Persistence and Immune Dysregulation in Long COVID
]]>
https://www.biorxiv.org/content/10.64898/2026.08.07.743616v1?rss=1"
LaFranchi, B.Maison, D. P.Vinden, J.Rodriguez, A. E.Tout, A.Grimbert, L.Velazquez, E.Vudali, U.Poblano, B. A.Dalhuisen, T.Cattle, J.Figueroa, T.Fudotan, Y.Luna, M. A.Ryder, D.Deswal, M.Abel, B. S.Lynch, J.Lipford, A.Razi, N.Steifman, C. B.McCann, H. N.Kataria, N.Girling, V.Thomas, R.Wang, C.Deitchman, A. N.Patel, S.Traglia, M.Tseng, Z. H.Szabo, G.Laszik, Z.Farrow, A.Sumimoto, N.Servellita, V.Hoh, R.Fehrman, E. A.Kelly, J. D.Martin, J. N.Deeks, S. G.Chiu, C. Y.Somsouk, M.Peluso, M. J.Henrich, T. J.2026-08-10doi:10.64898/2026.08.07.743616Cold Spring Harbor Laboratory Press2026-08-10
<![CDATA[
Protective pan-betacoronavirus neutralizing antibodies by vaccination
]]>
https://www.biorxiv.org/content/10.64898/2026.08.06.743418v1?rss=1"
Zhou, P.Feng, Z.He, W.-t.Zhu, Y.Yuan, M.Li, X.Zhang, Y.Vo, L.Capozzola, T.Callaghan, S.Mishra, N.Avillion, G.Dueker, K.Liang, B.Roy Chowdhury, R.Nedellec, R.Lee, W.-H.Allen, J. D.Walsh, A.Melo, M.McAnarney, E. T.Kumar, N. A.Rinaldi, W.Ferguson, M.Crispin, M. M.Ward, A. B.Irvine, D. J.Alameh, M.-G.Weissman, D.Baric, R.Gralinski, L. E.Wilson, I.Burton, D. R.Andrabi, R.2026-08-07doi:10.64898/2026.08.06.743418Cold Spring Harbor Laboratory Press2026-08-07
<![CDATA[
Phylogeny-aided detection of contamination in nearly 5 million SARS-CoV-2 genomes
]]>
https://www.biorxiv.org/content/10.64898/2026.08.07.743473v1?rss=1"
Anoufa, O.Ly-Trong, N.Goldman, N.De Maio, N.2026-08-07doi:10.64898/2026.08.07.743473Cold Spring Harbor Laboratory Press2026-08-07
<![CDATA[
Developing and Characterizing a Murine Model of In Utero Transmission of Ebola Virus
]]>
https://www.biorxiv.org/content/10.64898/2026.08.04.742335v1?rss=1"
Van Ert, H. A. A. M.Henderson, C.Smith, B. J.Richards, P.Kardin, E.Eubank, E.Fakhimi, M.Liebermann, M.Messingham, K.Santillan, M.Schultz, M.Marzi, A.Maury, W.2026-08-05doi:10.64898/2026.08.04.742335Cold Spring Harbor Laboratory Press2026-08-05
<![CDATA[
Viral Protease Nsp5 Hijacks La Autoantigen to Orchestrate the Translation to Replication Transition in SARS-CoV-2
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https://www.biorxiv.org/content/10.64898/2026.08.05.742966v1?rss=1"
Sahu, R.Raheja, H.Gaurav S N, G.Paul, S.V, S. S.Ghosh, P. K.Rajmani, R. S.Das, S.2026-08-05doi:10.64898/2026.08.05.742966Cold Spring Harbor Laboratory Press2026-08-05
<![CDATA[
MEGA-ODE: Learning Biologically Structured and Navigable Continuous Perturbation Dynamics from Sparse Omics
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https://www.biorxiv.org/content/10.64898/2026.08.05.742921v1?rss=1"
Xiang, Y.Li, Y.Tian, C.Gu, R.He, F.Wen, H.Xie, L.Zhou, P.2026-08-05doi:10.64898/2026.08.05.742921Cold Spring Harbor Laboratory Press2026-08-05
<![CDATA[
Adjuvanted mucosal vaccination enhances protection and prevents influenza virus transmission in the guinea pig model.
]]>
https://www.biorxiv.org/content/10.64898/2026.08.03.742639v1?rss=1"
Yan, V.Park, S.-C.Wiest, M. J.Laghlali, G.d'Acunzo, J. N.Chung, C.Levican, J.El-Ayache, F.Wong, P. T.Schotsaert, M.2026-08-04doi:10.64898/2026.08.03.742639Cold Spring Harbor Laboratory Press2026-08-04
<![CDATA[
Epitope-Focused Immunogens Confer Broad Protection against Coronaviruses
]]>
https://www.biorxiv.org/content/10.64898/2026.08.02.742375v1?rss=1"
Li, M.Chen, Q.Seo, J.Liu, Y.Peng, F.Huang, K.Dai, Z.Chen, C.Zhang, Z.Zhao, J.Wang, Z.Yuan, F.Ma, X.Martinez, D. R.Li, D.2026-08-04doi:10.64898/2026.08.02.742375Cold Spring Harbor Laboratory Press2026-08-04
<![CDATA[
A single Omicron mutation reshapes ORF3a-driven host-cell remodelling
]]>
https://www.biorxiv.org/content/10.64898/2026.08.02.742305v1?rss=1"
De Lucas, A.Padilla-Blanco, M.Merino-Herran, U.Mendoza-Garcia, L.Perez-Berna, A. J.Lopez-Ayllon, B. D.Scagnetti Zambrano, C.Grigas, J.Alboniga, O. E.Montesinos, J.Chichon, J.Fernandez, O.Mamprin, K.Fernandez-Rodriguez, R.Falcon-Perez, J. M.Martin-Cofreces, N. B.Garcia-Garcia, T.Garrido, J. J.Oliva, M. A.MONTOYA, M.2026-08-04doi:10.64898/2026.08.02.742305Cold Spring Harbor Laboratory Press2026-08-04
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<![CDATA[
Upregulation of distinct miRNAs in SARS-CoV-2 infected individuals: A differential signature of circulating miRNAs
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https://www.biorxiv.org/content/10.64898/2026.08.02.742360v1?rss=1"
Santos de Santana Silva, I. T.Rocha Gadelha, S.Ferraz Fehlberg, H.Barbosa Ferreira, F.de Melo Silva, M.Rezende, R. P.Albuquerque, G. R.Melo Mariano, A. P.Teixeira Dias, J. C.Barbosa Costa, G.Martins Kaneto, C.2026-08-04doi:10.64898/2026.08.02.742360Cold Spring Harbor Laboratory Press2026-08-04
<![CDATA[
Hantavirus Disease in Uruguay: Trends and Mortality Before and During the COVID-19 Pandemic.
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https://www.medrxiv.org/content/10.64898/2026.06.10.26355375v1?rss=1"
criscuolo, z.Blanco, L.Ferrara, F.Ciaccio, K.Gomez Carassale, L.Gonzalez Reyes, M.Machado Rivero, B.Sosa Dias, F.Facal Castro, J. A.2026-06-11doi:10.64898/2026.06.10.26355375Cold Spring Harbor Laboratory Press2026-06-11
<![CDATA[
A Clinical Predictor of Lung Molecular Endotype Identifies Heterogeneity in Corticosteroid Response in Severe COVID-19: an Emulated Target Trial
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https://www.medrxiv.org/content/10.64898/2026.06.08.26355201v1?rss=1"
Sines, B.Hagan, R.Jiang, X.Pavlechko, E.McClain, S.Hunt, X.Florou-Moreno, J.Acquadro, J.Risa, G.Valsaraj, V.Schisler, J.Wolfgang, M. C.2026-06-10doi:10.64898/2026.06.08.26355201Cold Spring Harbor Laboratory Press2026-06-10
<![CDATA[
A risk-of-contagion index using a Bayesian based model for the COVID-19 epidemic in Mexico
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https://www.medrxiv.org/content/10.64898/2026.06.09.26355274v1?rss=1"
Corona-Moreno, R.Acuna-Zegarra, M. A.Santana-Cibrian, M.Velasco-Hernandez, J. X.2026-06-10doi:10.64898/2026.06.09.26355274Cold Spring Harbor Laboratory Press2026-06-10
<![CDATA[
Estimating COVID-19 Cumulative Incidence from Seroprevalence Surveys accounting for Time-Varying Seroreversion: A Fully Bayesian Methodology
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https://www.medrxiv.org/content/10.64898/2026.06.09.26355264v1?rss=1"
Owusu-Boaitey, N.Meyer, M. J.Herrera-Esposito, D.Bottcher, L.Lukz, M.Cook, S.Stoto, M. A.Kraemer, J. D.2026-06-10doi:10.64898/2026.06.09.26355264Cold Spring Harbor Laboratory Press2026-06-10
<![CDATA[
Polypore Mushroom Mycelia for Treatment of Active COVID-19 Infection: A Randomized Clinical Trial
]]>
https://www.medrxiv.org/content/10.64898/2026.06.01.26354267v1?rss=1"
Saxe, G.Shubov, A.Smith, C. N.Golshan, S.Shekhtman, T.Wilson, S.Slater, D.Bair, Z. J.Beathard, C.Davis, R. A.MacElhern, L.Kao, L. K.Senowitz, P.Gosnell, N.Buchholz, D.Aguilar-Carreno, H.2026-06-09doi:10.64898/2026.06.01.26354267Cold Spring Harbor Laboratory Press2026-06-09
<![CDATA[
Computational and Experimental Antibody Affinity and Diagnostic Accuracy Quantification of SARS-CoV-2 SD2 Major Disulfide Loop Analog
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https://www.medrxiv.org/content/10.64898/2026.06.05.26353587v1?rss=1"
Pollo, B. A. L. V.Perias, G. A.Aguimatang, R. H.Espiritu, A. P.Ching, D.Idolor, M. I.King, R. A.Climacosa, F. M.Caoili, S. E.2026-06-08doi:10.64898/2026.06.05.26353587Cold Spring Harbor Laboratory Press2026-06-08
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Investigation of the continuous spread of SARS-CoV-2 in the post pandemic time - Insights into the reason for the sustained spread despite the establishment of population immunity
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https://www.medrxiv.org/content/10.64898/2026.06.05.26355009v1?rss=1"
Yi, B.2026-06-08doi:10.64898/2026.06.05.26355009Cold Spring Harbor Laboratory Press2026-06-08
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Disentangling infectiousness and susceptibility by age group using transmission pair data: a study of SARS-CoV-2 household transmission
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https://www.medrxiv.org/content/10.64898/2026.06.04.26354892v1?rss=1"
Leung, K. Y.Miura, F.Backer, J. A.2026-06-05doi:10.64898/2026.06.04.26354892Cold Spring Harbor Laboratory Press2026-06-05
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Cumulative In-Context Learning versus Simple Historical Weighting for Real-Time Geographic Origin Identification of Ongoing Epidemic Waves: A Comparative Evaluation Using Eight COVID-19 Waves in Japan
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https://www.medrxiv.org/content/10.64898/2026.05.23.26353936v1?rss=1"
Nakagawa, S.Yamamoto, A.2026-05-25doi:10.64898/2026.05.23.26353936Cold Spring Harbor Laboratory Press2026-05-25
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Predictors of maternal mental health and coping during the COVID-19 pandemic: A multi-country cross-sectional study
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https://www.medrxiv.org/content/10.64898/2026.05.25.26353920v1?rss=1"
Liu, C.Liu, M.Dib, S.Ferrando, M.Kagawa, M.Ongprasert, K.Rougeaux, E.Shukri, N. H. M.Vazquez, A.Wells, J.Fewtrell, M.Yu, J.2026-05-25doi:10.64898/2026.05.25.26353920Cold Spring Harbor Laboratory Press2026-05-25
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TRENDS-Thai: decadal trends of dengue, chikungunya, and hand, foot, and mouth disease in Thailand (2016-2025): a multi-disease time-series analysis of COVID-19 disruption
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https://www.medrxiv.org/content/10.64898/2026.05.21.26353796v1?rss=1"
Pongpirul, W.Ahmed, M. M.Pongpirul, K.2026-05-24doi:10.64898/2026.05.21.26353796Cold Spring Harbor Laboratory Press2026-05-24
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Effect of Antiseptic Mouthwash/Gargling Solutions on SARS-CoV-2 Viral Load: A Randomized Clinical Trial
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https://www.medrxiv.org/content/10.64898/2026.05.20.26353686v1?rss=1"
Banava, S.Radaic, A.Pachiyappan, K.Cheng, N. F.Hernandez-Kapila, Y. L.Gansky, S. A.2026-05-22doi:10.64898/2026.05.20.26353686Cold Spring Harbor Laboratory Press2026-05-22
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Caregiving Demands and Depression Symptoms among Caregivers of Individuals with Down Syndrome during the COVID-19 Pandemic
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https://www.medrxiv.org/content/10.64898/2026.05.20.26353699v1?rss=1"
Nguyen, J.Wall, C.Jo, E.Allen, L. K.Wheeler, N.Baumer, N.D'Aguilar, A.York, T. P.Capone, G.Jackson-Cook, C.Amstadter, A. B.Brown, R. C.2026-05-22doi:10.64898/2026.05.20.26353699Cold Spring Harbor Laboratory Press2026-05-22
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A longitudinal cohort study comparing clinical trials registered on ClinicalTrials.gov that stopped during the first three years of the SARS-CoV-2 pandemic with trials that stopped in the three years prior
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https://www.medrxiv.org/content/10.64898/2026.05.20.26353581v1?rss=1"
Carlisle, B. G.Hutchinson, N.Moyer, H.2026-05-22doi:10.64898/2026.05.20.26353581Cold Spring Harbor Laboratory Press2026-05-22
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Ischemic stroke after bivalent mRNA COVID-19 vaccination and influenza vaccination during the 2022-2023 season: a multi-site self-controlled case series study
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https://www.medrxiv.org/content/10.64898/2026.05.20.26353716v1?rss=1"
Xu, S.Sy, L. S.Hong, V.Farrington, P.Glenn, S. C.Kim, S.Ryan, D. S.Tubert, J. E.Tong, P.Lewin, B. J.Tseng, H. F.Carbayo, A.Davis, C.Sangha, N. S.Belongia, E. A.Sundaram, M. E.Nelson, J. C.Daley, M. F.Klein, N. P.Fireman, B.Haapala, J.Hurley, L. P.Irving, S. A.Cocoros, N. M.Weintraub, E. S.Duffy, J.Qian, L.2026-05-22doi:10.64898/2026.05.20.26353716Cold Spring Harbor Laboratory Press2026-05-2265 years) and history of documented SARS-CoV-2 infection.
ResultsA total of 6,510 first-ever ischemic strokes were identified among more than 6.8 million participants. Among recipients of Pfizer-BioNTech bivalent COVID-19 and influenza vaccines, no statistically significant increased risk of first-ever ischemic stroke was observed following bivalent COVID-19 vaccination (RI = 0.94; 95% CI: 0.63-1.41), influenza vaccination (RI = 0.95; 95% CI: 0.82-1.10), or same-day coadministration (RI = 1.15; 95% CI: 0.88-1.49) within 1- 21-day risk intervals; findings were similar for 1-42-day intervals. Comparable null results were observed for Moderna vaccines and across all subgroups, secondary, and exploratory outcomes.
ConclusionNo increased risk of ischemic stroke was found following bivalent mRNA COVID-19 vaccination, influenza vaccination, or their coadministration in this multi-site SCCS study. These findings are consistent with previous studies and underscore the importance of continued vaccine safety monitoring.
HighlightsO_LIWe evaluated ischemic stroke risk after bivalent mRNA COVID-19 vaccination, influenza vaccination, and their coadministration.
C_LIO_LINo increased risk of ischemic stroke was observed within 1-21 or 1-42 days following these vaccination exposures.
C_LIO_LIFindings were consistent across vaccine type, age group, and prior SARS-CoV-2 infection status.
C_LIO_LIThese results support the safety of bivalent mRNA COVID-19 vaccines with respect to ischemic stroke.
C_LI
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Fronto-limbic and Thalamocortical Network Alterations after COVID-19 Recovery: a Multimodal MRI Study
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https://www.medrxiv.org/content/10.64898/2026.05.19.26353613v1?rss=1"
Mishra, S. S.Misra, R.Douaud, G.Biswal, B.Gandhi, T.2026-05-22doi:10.64898/2026.05.19.26353613Cold Spring Harbor Laboratory Press2026-05-22 0.05).
ConclusionsOur findings indicate that COVID-19 recovery is associated with enduring alterations in fronto-limbic and thalamo-cortical circuits, most prominently in individuals with severe infection. Convergent structural and functional changes involving the orbitofrontal cortex and mediodorsal thalamus suggest network-specific reorganisation that may underpin persistent cognitive and affective symptoms of post-COVID syndrome.
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COVID-19 vaccination and the risk of cardiovascular and thromboembolic events after SARS-CoV-2 infection: a systematic review and meta-analysis
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https://www.medrxiv.org/content/10.64898/2026.05.21.26353568v1?rss=1"
Heymans, S.Heidecker, B.Marjenberg, Z.Green, R.Pliakas, T.Lip, G. Y. H.Lüscher, T. F.Abduljawad, S.2026-05-22doi:10.64898/2026.05.21.26353568Cold Spring Harbor Laboratory Press2026-05-22
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Sexually Transmitted and Bloodborne Infections, Methamphetamine Use, and COVID-19 Vaccination in Manitoba, Canada: A Retrospective Matched Cohort Analysis Using Population-Based Administrative Healthcare Data (2020-2022)
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https://www.medrxiv.org/content/10.64898/2026.05.18.26353507v1?rss=1"
Shaw, S. Y. Y.Mahar, A.Bailey, K.Payne, M.Kindrachuk, J.Kelly, C.Friesen, K. J.Bernstein, C. N.Reimer, J.Becker, M. L.McClarty, L. M.Stein, D.Nickel, N. C.2026-05-21doi:10.64898/2026.05.18.26353507Cold Spring Harbor Laboratory Press2026-05-21
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The control gap in long COVID research: a meta-epidemiological analysis
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https://www.medrxiv.org/content/10.64898/2026.05.16.26353381v1?rss=1"
Panagiotopoulos, A.-P.Laskaris, A.Tsakri, D.Manoussopoulos, Y.Anastassopoulou, C.Tsakris, A.Ioannidis, J.2026-05-21doi:10.64898/2026.05.16.26353381Cold Spring Harbor Laboratory Press2026-05-21
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Predicting Functional Changes in Down Syndrome During the COVID-19 Pandemic: The Role of Biopsychosocial Determinants of Health
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https://www.medrxiv.org/content/10.64898/2026.05.19.26353577v1?rss=1"
Jo, E.Wall, C.Allen, L. K.Wheeler, N.Baumer, N.D'Aguilar, A.York, T. P.Capone, G.Jackson-Cook, C.Amstadter, A. B.Brown, R. C.2026-05-21doi:10.64898/2026.05.19.26353577Cold Spring Harbor Laboratory Press2026-05-21