Channel:  Harvard Program in Therapeutic Sciences

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

103 Articles

UnMICST: Deep learning with real augmentation for robust segmentation of highly multiplexed images of human tissues
Yapp, C., Novikov, E., Jang, W.-D., Vallius, T., Chen, Y.-A., Cicconet, M., Maliga, Z., Jacobson, C. A., Wei, D., Santagata, S., Pfister, H., Sorger, P. K.
10.1101/2021.04.02.438285 — Posted: 2022-02-25
Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2
Patino-Galindo, J. A., Filip, I., Chowdhury, R., Maranas, C. D., Sorger, P. K., AlQuraishi, M., Rabadan, R.
10.1101/2020.02.10.942748 — Posted: 2021-04-06
Stitching and registering highly multiplexed whole slide images of tissues and tumors using ASHLAR
Muhlich, J. L., Chen, Y.-A., Yapp, C., Russell, D. P. W., Santagata, S., Sorger, P. K.
10.1101/2021.04.20.440625 — Posted: 2022-04-25
The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution
Nirmal, A. J., Maliga, Z., Vallius, T., Quattrochi, B., Chen, A. A., Jacobson, C. A., Pelletier, R. J., Yapp, C., Arias-Camison, R., Chen, Y.-A., Lian, C. G., Murphy, G. F., Santagata, S., Sorger, P. K.
10.1101/2021.05.23.445310 — Posted: 2022-02-14
Fides: Reliable Trust-Region Optimization for Parameter Estimation of Ordinary Differential Equation Models
Froehlich, F., Sorger, P. K.
10.1101/2021.05.20.445065 — Posted: 2022-02-22
Cancer patient survival can be accurately parameterized, revealing time-dependent therapeutic effects and doubling the precision of small trials
Plana, D., Fell, G., Alexander, B. M., Palmer, A. C., Sorger, P. K.
10.1101/2021.05.14.442837 — Posted: 2021-05-17
Temporal and spatial topography of cell proliferation in cancer
Gaglia, G., Kabraji, S., Argyropoulou, D., Dai, Y., Wang, S., Bergholz, J., Coy, S., Lin, J.-R., Jeselsohn, R., Metzger, O., Winer, E. P., Dillon, D. A., Zhao, J. J., Sorger, P. K., Santagata, S.
10.1101/2021.05.16.443704 — Posted: 2021-05-17
Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes
Doherty, L. M., Mills, C. E., Boswell, S. A., Liu, X., Hoyt, C. T., Gyori, B. M., Buhrlage, S. J., Sorger, P. K.
10.1101/2021.08.06.455458 — Posted: 2021-08-09
Single-sequence protein structure prediction using language models from deep learning
Chowdhury, R., Bouatta, N., Biswas, S., Rochereau, C., Church, G. M., Sorger, P. K., AlQuraishi, M. N.
10.1101/2021.08.02.454840 — Posted: 2021-08-04
A LINCS microenvironment perturbation resource for integrative assessment of ligand-mediated molecular and phenotypic responses
Gross, S. M., Dane, M. A., Smith, R. L., Devlin, K., Mclean, I., Derrick, D., Mills, C., Subramanian, K., London, A., Torre, D., Erdem, C., Lyons, N., Natoli, T., Pessa, S., Lu, X., Mullahoo, J., Li, J., Adam, M., Wassie, B., Liu, M., Kilburn, D. F., Liby, T., Bucher, E., Sanchez-Aguila, C., Daily, K., Omberg, L., Wang, Y., Jacobson, C., Yapp, C., Chung, M., Vidovic, D., Lu, Y., Schurer, S., Lee, A., Pillai, A., Subramanian, A., Papanastasiou, M., Fraenkel, E., Feiler, H., Mills, G. B., Jaffe, J., Ma'ayan, A., Birtwistle, M. R., Sorger, P. K., Korkola, J. E., Gray, J. W., Heiser, L. M.
10.1101/2021.08.06.455429 — Posted: 2021-08-09

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