Channel:  Harvard Program in Therapeutic Sciences

126 Articles

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Multi-omics profiling establishes the polypharmacology of FDA Approved CDK4/6 inhibitors and the potential for differential clinical activity
Hafner, M., Mills, C. E., Subramanian, K., Chen, C., Chung, M., Boswell, S. A., Everley, R. A., Liu, C., Walmsley, C. S., Juric, D., Sorger, P.
10.1101/211680 — Posted: 2019-03-19
Adaptation of human iPSC-derived cardiomyocytes to tyrosine kinase inhibitors reduces acute cardiotoxicity via metabolic reprogramming
Wang, H., Sheehan, R. P., Palmer, A. C., Everley, R. A., Boswell, S. A., Ron-Harel, N., Ringel, A. E., Holton, K. M., Jacobson, C. A., Erickson, A. R., Maliszewski, L., Haigis, M. C., Sorger, P. K.
10.1101/365841 — Posted: 2019-03-12
A multi-center study on factors influencing the reproducibility of in vitro drug-response studies
Niepel, M., Hafner, M., Mills, C., Subramanian, K., Williams, E. H., Chung, M., Gaudio, B., Barrette, A. M., Stern, A. D., Hu, B., Korkola, J. E., LINCS Consortium, , Gray, J. W., Birtwistle, M. R., Heiser, L. M., Sorger, P. K.
10.1101/213553 — Posted: 2019-02-05
Re-curation and Rational Enrichment of Knowledge Graphs in Biological Expression Language
Hoyt, C., Domingo-Fernandez, D., Aldisi, R., Xu, L., Kolpeja, K., Spalek, S., Wollert, E., Bachman, J., Gyori, B., Greene, P., Hofmann-Apitius, M.
10.1101/536409 — Posted: 2019-01-31
Highly multiplexed in situ protein imaging with signal amplification by Immuno-SABER
Saka, S. K., Wang, Y., Kishi, J. Y., Zhu, A., Zeng, Y., Xie, W., Kirli, K., Yapp, C., Cicconet, M., Beliveau, B. J., Lapan, S. W., Yin, S., Lin, M., Boyden, E. S., Kaeser, P. S., Pihan, G., Church, G. M., Yin, P.
10.1101/507566 — Posted: 2018-12-28
End-to-end differentiable learning of protein structure
AlQuraishi, M.
10.1101/265231 — Posted: 2018-08-29
pNeRF: Parallelized Conversion from Internal to Cartesian Coordinates
AlQuraishi, M.
10.1101/385450 — Posted: 2018-08-06
Cheminformatics tools for analyzing and designing optimized small molecule libraries
Moret, N., Clark, N., Hafner, M., Wang, Y., Lounkine, E., Medvedovic, M., Wang, J., Gray, N., Jenkins, J., Sorger, P.
10.1101/358978 — Posted: 2018-06-29
Machine characterization of rat toxin responses identifies disease states, tolerance mechanisms and organ to whole-body communication
Shimada, K., Mitchison, T.
10.1101/322446 — Posted: 2018-05-28
Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes
Lin, J.-R., Izar, B., Mei, S., Wang, S., Shah, P., Yapp, C., Santagata, S., Sorger, P.
10.1101/151738 — Posted: 2018-05-10

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