Channel:  Harvard Program in Therapeutic Sciences

119 Articles

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Multiplexed and reproducible high content screening of live and fixed cells using the Dye Drop method
Mills, C. E., Subramanian, K., Hafner, M., Niepel, M., Gerosa, L., Chung, M., Victor, C., Gaudio, B., Yapp, C., Nirmal, A. J., Clark, N., Sorger, P. K.
10.1101/2021.08.27.457854 — Posted: 2022-07-08
KINOMO: A non-negative matrix factorization framework for recovering intra- and inter-tumoral heterogeneity from single-cell RNA-seq data
Tagore, S., Wang, Y., Biermann, J., Rabadan, R., Azizi, E., Izar, B.
10.1101/2022.05.02.490362 — Posted: 2022-05-04
Stitching and registering highly multiplexed whole slide images of tissues and tumors using ASHLAR
Muhlich, J. L., Chen, Y.-A., Yapp, C., Russell, D. P. W., Santagata, S., Sorger, P. K.
10.1101/2021.04.20.440625 — Posted: 2022-04-25
UnMICST: Deep learning with real augmentation for robust segmentation of highly multiplexed images of human tissues
Yapp, C., Novikov, E., Jang, W.-D., Vallius, T., Chen, Y.-A., Cicconet, M., Maliga, Z., Jacobson, C. A., Wei, D., Santagata, S., Pfister, H., Sorger, P. K.
10.1101/2021.04.02.438285 — Posted: 2022-02-25
Fides: Reliable Trust-Region Optimization for Parameter Estimation of Ordinary Differential Equation Models
Froehlich, F., Sorger, P. K.
10.1101/2021.05.20.445065 — Posted: 2022-02-22
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
Froehlich, F., Gerosa, L., Muhlich, J. L., Sorger, P. K.
10.1101/2022.02.17.480899 — Posted: 2022-02-18
The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution
Nirmal, A. J., Maliga, Z., Vallius, T., Quattrochi, B., Chen, A. A., Jacobson, C. A., Pelletier, R. J., Yapp, C., Arias-Camison, R., Chen, Y.-A., Lian, C. G., Murphy, G. F., Santagata, S., Sorger, P. K.
10.1101/2021.05.23.445310 — Posted: 2022-02-14
Single Cell Spatial Analysis Reveals the Topology of Immunomodulatory Purinergic Signaling in Glioblastoma
Coy, S., Wang, S., Stopka, S. A., Lin, J.-R., Rashid, R., Yapp, C., Ritch, C. C., Khadka, P., Regan, M., Hwang, J., Wen, P. Y., Bandopadhayay, P., Ligon, K. L., Agar, N. Y., Sorger, P. K., Touat, M., Santagata, S.
10.1101/2022.01.12.475925 — Posted: 2022-01-12
Characterization of metabolic compartmentalization in the liver using spatially resolved metabolomics
van der Reest, J., Stopka, S. A., Abdelmoula, W. M., Ruiz, D. F., Joshi, S., Ringel, A., Haigis, M. C., Agar, N. Y. R.
10.1101/2021.12.13.472421 — Posted: 2021-12-13
Design principles to assemble drug combinations for effective tuberculosis therapy using interpretable pairwise drug response measurements
Larkins-Ford, J., Degefu, Y. N., Van, N., Sokolov, A., Aldridge, B. B.
10.1101/2021.12.05.471248 — Posted: 2021-12-06

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